Clinicopathologic correlation of autophagy-related Beclin-1 expression in gallbladder cancer

Jae Young Park, Hyun Soo Kim, Hyuck Cho, Nam Chul Kim, Kyu Hee Chae, Won Seo Park, Youn Wha Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background/Aims: Autophagy plays critical roles in both cell survival and cell death. Beclin-1, a key modulator of autophagy function, is considered a haploinsufficient tumor suppressor. The role of Beclin-1 expression in cancer is still controversial. Some studies favor the idea that autophagy suppresses tumor development, whereas other researchers suggest that autophagy enhances tumorigenesis. The expression and function of Beclin-1 in gallbladder cancer (GBCA) remain largely unknown. Methodology: We performed immunohistochemical staining for Beclin-1 in 119 GBCA cases, and investigated whether Beclin-1 expression correlated with clinicopathologic characteristics and prognosis of patients. Results: Beclin-1 was expressed in the cytoplasm of cancer cells with occasional nuclear staining in 53 (44.5%) of the 119 cases of GBCA with no expression in adjacent normal epithelial cells. Increased expression of Beclin-1 was significantly associated with longer survival rate of patients with GBCA in univariate (p=0.006) and multivariate analyses (p=0.005). There is no association between Beclin-1 expression and clinicopathologic characteristics. Conclusions: Beclin-1 was highly expressed in GBCA, and positive expression in cancer cells was significantly related with favorable prognosis in GBCA patients. Our results suggest that the expression of Beclin-1 may be an independent predictive marker of favorable prognosis in GBCA.

Original languageEnglish
Pages (from-to)1494-1500
Number of pages7
JournalHepato-gastroenterology
Volume61
Issue number134
DOIs
Publication statusPublished - 2014 Sep

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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