Clinicopathologic correlation of autophagy-related Beclin-1 expression in gallbladder cancer

Jae Young Park, Hyunsoo Kim, Hyuck Cho, Nam Chul Kim, Kyu Hee Chae, Won Seo Park, Youn Wha Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background/Aims: Autophagy plays critical roles in both cell survival and cell death. Beclin-1, a key modulator of autophagy function, is considered a haploinsufficient tumor suppressor. The role of Beclin-1 expression in cancer is still controversial. Some studies favor the idea that autophagy suppresses tumor development, whereas other researchers suggest that autophagy enhances tumorigenesis. The expression and function of Beclin-1 in gallbladder cancer (GBCA) remain largely unknown. Methodology: We performed immunohistochemical staining for Beclin-1 in 119 GBCA cases, and investigated whether Beclin-1 expression correlated with clinicopathologic characteristics and prognosis of patients. Results: Beclin-1 was expressed in the cytoplasm of cancer cells with occasional nuclear staining in 53 (44.5%) of the 119 cases of GBCA with no expression in adjacent normal epithelial cells. Increased expression of Beclin-1 was significantly associated with longer survival rate of patients with GBCA in univariate (p=0.006) and multivariate analyses (p=0.005). There is no association between Beclin-1 expression and clinicopathologic characteristics. Conclusions: Beclin-1 was highly expressed in GBCA, and positive expression in cancer cells was significantly related with favorable prognosis in GBCA patients. Our results suggest that the expression of Beclin-1 may be an independent predictive marker of favorable prognosis in GBCA.

Original languageEnglish
Pages (from-to)1494-1500
Number of pages7
JournalHepato-gastroenterology
Volume61
Issue number134
DOIs
Publication statusPublished - 2014 Jan 1

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Gallbladder Neoplasms
Autophagy
Neoplasms
Beclin-1
Staining and Labeling
Cell Survival
Carcinogenesis
Cytoplasm
Cell Death
Multivariate Analysis
Survival Rate
Epithelial Cells
Research Personnel

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Park, J. Y., Kim, H., Cho, H., Kim, N. C., Chae, K. H., Park, W. S., & Kim, Y. W. (2014). Clinicopathologic correlation of autophagy-related Beclin-1 expression in gallbladder cancer. Hepato-gastroenterology, 61(134), 1494-1500. https://doi.org/10.5754/hge13360
Park, Jae Young ; Kim, Hyunsoo ; Cho, Hyuck ; Kim, Nam Chul ; Chae, Kyu Hee ; Park, Won Seo ; Kim, Youn Wha. / Clinicopathologic correlation of autophagy-related Beclin-1 expression in gallbladder cancer. In: Hepato-gastroenterology. 2014 ; Vol. 61, No. 134. pp. 1494-1500.
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abstract = "Background/Aims: Autophagy plays critical roles in both cell survival and cell death. Beclin-1, a key modulator of autophagy function, is considered a haploinsufficient tumor suppressor. The role of Beclin-1 expression in cancer is still controversial. Some studies favor the idea that autophagy suppresses tumor development, whereas other researchers suggest that autophagy enhances tumorigenesis. The expression and function of Beclin-1 in gallbladder cancer (GBCA) remain largely unknown. Methodology: We performed immunohistochemical staining for Beclin-1 in 119 GBCA cases, and investigated whether Beclin-1 expression correlated with clinicopathologic characteristics and prognosis of patients. Results: Beclin-1 was expressed in the cytoplasm of cancer cells with occasional nuclear staining in 53 (44.5{\%}) of the 119 cases of GBCA with no expression in adjacent normal epithelial cells. Increased expression of Beclin-1 was significantly associated with longer survival rate of patients with GBCA in univariate (p=0.006) and multivariate analyses (p=0.005). There is no association between Beclin-1 expression and clinicopathologic characteristics. Conclusions: Beclin-1 was highly expressed in GBCA, and positive expression in cancer cells was significantly related with favorable prognosis in GBCA patients. Our results suggest that the expression of Beclin-1 may be an independent predictive marker of favorable prognosis in GBCA.",
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Clinicopathologic correlation of autophagy-related Beclin-1 expression in gallbladder cancer. / Park, Jae Young; Kim, Hyunsoo; Cho, Hyuck; Kim, Nam Chul; Chae, Kyu Hee; Park, Won Seo; Kim, Youn Wha.

In: Hepato-gastroenterology, Vol. 61, No. 134, 01.01.2014, p. 1494-1500.

Research output: Contribution to journalArticle

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