Clinicopathologic correlation of beclin-1 expression in pancreatic ductal adenocarcinoma

Hyun Soo Kim, Sun Ho Lee, Sung Im Do, Sung Jig Lim, Yong Koo Park, Youn Wha Kim

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31 Citations (Scopus)

Abstract

Beclin-1 has emerged as an autophagy gene in a variety of human carcinomas. The aim of this study was to evaluate beclin-1 expression and to determine its prognostic significance in patients with pancreatic ductal adenocarcinoma (PDA).We performed immunohistochemical staining for beclin-1 in 63 cases of PDA. We investigated whether beclin-1 expression correlated with clinicopathologic characteristics and patient outcomes. Beclin-1 expression was absent in normal pancreatic islet cells, acinar cells, and ductal epithelial cells. In contrast, in PDA, beclin-1 showed positive immunoreactivity in 14 of 63 (22.2%) PDA cases, while the remaining 49 (77.8%) PDA cases exhibited negative beclin-1 expression. We found significant associations between increased beclin-1 expression and the absence of lymphatic invasion (P = 0.032) and low rate of distant metastasis (P = 0.001). Univariate analysis of survival showed that the median distant metastasis-free survival of beclin-1-negative PDA patients (10 months) was significantly shorter than that of beclin-1-positive PDA patients (21 months; P = 0.031).Our results suggest that increased beclin-1 expression plays a role in the inhibition of PDA progression.

Original languageEnglish
Pages (from-to)247-252
Number of pages6
JournalPathology Research and Practice
Volume207
Issue number4
DOIs
Publication statusPublished - 2011 Apr 15

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All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Cell Biology

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