Clinicopathologic features of gastric carcinoma with lymphoid stroma in early gastric cancer

Cheal Wung Huh; Da Hyun Jung; Hyunki Kim; Hoguen Kim; Young Hoon Youn; Hyojin Park; Jong Won Kim; Seung Ho Choi; Sung Hoon Noh; Jie Hyun Kim

doi:10.1002/jso.24385

Clinicopathologic features of gastric carcinoma with lymphoid stroma in early gastric cancer

Cheal Wung Huh, Da Hyun Jung, Hyunki Kim, Hoguen Kim, Young Hoon Youn, Hyojin Park, Jong Won Kim, Seung Ho Choi, Sung Hoon Noh, Jie Hyun Kim

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Background and Objectives: Gastric carcinoma with lymphoid stroma (GCLS) is a rare variant of gastric cancer. The aims of this study were to investigate the clinicopathologic features of GCLS in early gastric cancer (EGC). Methods: Analysis included 3,385 patients who were diagnosed with EGC after surgery between 2005 and 2012. This study compared GCLS with non-GCLS patients in terms of clinicopathological features including lymph node metastasis (LNM). Results: Forty-one (1.2%) patients were diagnosed as GCLS among those with EGC. When GCLS and non-GCLS patients were compared, the GCLS group showed a greater predominance among males, greater tendency towards proximal location, a more elevated gross appearance, and deeper submucosal invasion. In particular, more than 90% of GCLS cases showed deep submucosal invasion. The LNM rate was significantly lower in GCLS than non-GCLS cases after adjustment for depth of invasion. Among the GCLS group, there was no LNM in the cases with lesions confined to the mucosa or submucosal invasive lesions with tumor size ≤10 mm. Conclusions: In EGC, GCLS showed deeper submucosal invasion and a lower LNM rate compared with non-GCLS. Thus, clinical considerations of GCLS may be helpful to decide on a specific cancer treatment. J. Surg. Oncol. 2016;114:769–772.

Original language	English
Pages (from-to)	769-772
Number of pages	4
Journal	Journal of surgical oncology
Volume	114
Issue number	6
DOIs	https://doi.org/10.1002/jso.24385
Publication status	Published - 2016 Nov 1

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012R1A1A1042417). The English in this document has been checked by at least two professional editors, both native speakers of English. For a certificate, please see: http://www.textcheck.com/certificate/9RQgrX

Publisher Copyright:
© 2016 Wiley Periodicals, Inc.

All Science Journal Classification (ASJC) codes

Surgery
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jso.24385

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title = "Clinicopathologic features of gastric carcinoma with lymphoid stroma in early gastric cancer",

abstract = "Background and Objectives: Gastric carcinoma with lymphoid stroma (GCLS) is a rare variant of gastric cancer. The aims of this study were to investigate the clinicopathologic features of GCLS in early gastric cancer (EGC). Methods: Analysis included 3,385 patients who were diagnosed with EGC after surgery between 2005 and 2012. This study compared GCLS with non-GCLS patients in terms of clinicopathological features including lymph node metastasis (LNM). Results: Forty-one (1.2%) patients were diagnosed as GCLS among those with EGC. When GCLS and non-GCLS patients were compared, the GCLS group showed a greater predominance among males, greater tendency towards proximal location, a more elevated gross appearance, and deeper submucosal invasion. In particular, more than 90% of GCLS cases showed deep submucosal invasion. The LNM rate was significantly lower in GCLS than non-GCLS cases after adjustment for depth of invasion. Among the GCLS group, there was no LNM in the cases with lesions confined to the mucosa or submucosal invasive lesions with tumor size ≤10 mm. Conclusions: In EGC, GCLS showed deeper submucosal invasion and a lower LNM rate compared with non-GCLS. Thus, clinical considerations of GCLS may be helpful to decide on a specific cancer treatment. J. Surg. Oncol. 2016;114:769–772.",

author = "Huh, {Cheal Wung} and Jung, {Da Hyun} and Hyunki Kim and Hoguen Kim and Youn, {Young Hoon} and Hyojin Park and Kim, {Jong Won} and Choi, {Seung Ho} and Noh, {Sung Hoon} and Kim, {Jie Hyun}",

note = "Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012R1A1A1042417). The English in this document has been checked by at least two professional editors, both native speakers of English. For a certificate, please see: http://www.textcheck.com/certificate/9RQgrX Publisher Copyright: {\textcopyright} 2016 Wiley Periodicals, Inc.",

year = "2016",

month = nov,

day = "1",

doi = "10.1002/jso.24385",

language = "English",

volume = "114",

pages = "769--772",

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TY - JOUR

T1 - Clinicopathologic features of gastric carcinoma with lymphoid stroma in early gastric cancer

AU - Huh, Cheal Wung

AU - Jung, Da Hyun

AU - Kim, Hyunki

AU - Kim, Hoguen

AU - Youn, Young Hoon

AU - Park, Hyojin

AU - Kim, Jong Won

AU - Choi, Seung Ho

AU - Noh, Sung Hoon

AU - Kim, Jie Hyun

N1 - Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012R1A1A1042417). The English in this document has been checked by at least two professional editors, both native speakers of English. For a certificate, please see: http://www.textcheck.com/certificate/9RQgrX Publisher Copyright: © 2016 Wiley Periodicals, Inc.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Background and Objectives: Gastric carcinoma with lymphoid stroma (GCLS) is a rare variant of gastric cancer. The aims of this study were to investigate the clinicopathologic features of GCLS in early gastric cancer (EGC). Methods: Analysis included 3,385 patients who were diagnosed with EGC after surgery between 2005 and 2012. This study compared GCLS with non-GCLS patients in terms of clinicopathological features including lymph node metastasis (LNM). Results: Forty-one (1.2%) patients were diagnosed as GCLS among those with EGC. When GCLS and non-GCLS patients were compared, the GCLS group showed a greater predominance among males, greater tendency towards proximal location, a more elevated gross appearance, and deeper submucosal invasion. In particular, more than 90% of GCLS cases showed deep submucosal invasion. The LNM rate was significantly lower in GCLS than non-GCLS cases after adjustment for depth of invasion. Among the GCLS group, there was no LNM in the cases with lesions confined to the mucosa or submucosal invasive lesions with tumor size ≤10 mm. Conclusions: In EGC, GCLS showed deeper submucosal invasion and a lower LNM rate compared with non-GCLS. Thus, clinical considerations of GCLS may be helpful to decide on a specific cancer treatment. J. Surg. Oncol. 2016;114:769–772.

AB - Background and Objectives: Gastric carcinoma with lymphoid stroma (GCLS) is a rare variant of gastric cancer. The aims of this study were to investigate the clinicopathologic features of GCLS in early gastric cancer (EGC). Methods: Analysis included 3,385 patients who were diagnosed with EGC after surgery between 2005 and 2012. This study compared GCLS with non-GCLS patients in terms of clinicopathological features including lymph node metastasis (LNM). Results: Forty-one (1.2%) patients were diagnosed as GCLS among those with EGC. When GCLS and non-GCLS patients were compared, the GCLS group showed a greater predominance among males, greater tendency towards proximal location, a more elevated gross appearance, and deeper submucosal invasion. In particular, more than 90% of GCLS cases showed deep submucosal invasion. The LNM rate was significantly lower in GCLS than non-GCLS cases after adjustment for depth of invasion. Among the GCLS group, there was no LNM in the cases with lesions confined to the mucosa or submucosal invasive lesions with tumor size ≤10 mm. Conclusions: In EGC, GCLS showed deeper submucosal invasion and a lower LNM rate compared with non-GCLS. Thus, clinical considerations of GCLS may be helpful to decide on a specific cancer treatment. J. Surg. Oncol. 2016;114:769–772.

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SP - 769

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JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

IS - 6

ER -

Clinicopathologic features of gastric carcinoma with lymphoid stroma in early gastric cancer

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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