Clinicopathologic features of solid variant papillary thyroid cancer

Hojin Chang, Seok Mo Kim, Ki Won Chun, Bup Woo Kim, Yong Sang Lee, Hang-Seok Chang, Soon Won Hong, Cheong Soo Park

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12 Citations (Scopus)

Abstract

Background: Solid variant papillary thyroid cancer (SVPTC) is a rare type of thyroid malignancy whose clinical characteristics remain poorly defined. Therefore, we evaluated the characteristics of 14 patients with SVPTC treated at our institution. Methods: Of the 6052 patients with papillary thyroid cancer (PTC) evaluated at our institution between January 2008 and December 2011, 14 (0.23%) had SVPTC and were analysed retrospectively. Results: Of the 14 patients with SVPTC, two were men and 12 were women, with a mean age of 48.2 years (range: 33-72 years). The mean follow-up period was 24 months (range: 8-36 months). All patients were assessed preoperatively by ultrasound-guided fine needle aspiration cytology (FNAC), with the diagnosis confirmed by permanent pathology and immunohistochemical staining performed by a specialized endocrine pathologist. Only one patient was diagnosed with SVPTC by preoperative FNAC, whereas 11 (78.6%) were diagnosed with PTC or suspected of having PTC. The mean tumour size was 1.02 ± 0.30cm, with all tumours less than 2.0cm in diameter. The infiltrative tumour margins were observed in eight patients (57.1%) and the extrathyroidal invasion in seven (50.0%). The central lymph node metastases were found in five patients (35.7%), and the lateral lymph node metastasis in one (7.1%). No patient experienced tumour recurrence or distant metastasis during follow-up. Conclusions: Despite the small sample size and the short follow-up period, our results indicate that SVPTC may not be as aggressive a subtype as previously thought.

Original languageEnglish
Pages (from-to)380-382
Number of pages3
JournalANZ Journal of Surgery
Volume84
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1

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Neoplasms
Neoplasm Metastasis
Fine Needle Biopsy
Cell Biology
Lymph Nodes
Papillary Thyroid cancer
Sample Size
Thyroid Gland
Pathology
Staining and Labeling
Recurrence
Pathologists

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Chang, H., Kim, S. M., Chun, K. W., Kim, B. W., Lee, Y. S., Chang, H-S., ... Park, C. S. (2014). Clinicopathologic features of solid variant papillary thyroid cancer. ANZ Journal of Surgery, 84(5), 380-382. https://doi.org/10.1111/ans.12307
Chang, Hojin ; Kim, Seok Mo ; Chun, Ki Won ; Kim, Bup Woo ; Lee, Yong Sang ; Chang, Hang-Seok ; Hong, Soon Won ; Park, Cheong Soo. / Clinicopathologic features of solid variant papillary thyroid cancer. In: ANZ Journal of Surgery. 2014 ; Vol. 84, No. 5. pp. 380-382.
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title = "Clinicopathologic features of solid variant papillary thyroid cancer",
abstract = "Background: Solid variant papillary thyroid cancer (SVPTC) is a rare type of thyroid malignancy whose clinical characteristics remain poorly defined. Therefore, we evaluated the characteristics of 14 patients with SVPTC treated at our institution. Methods: Of the 6052 patients with papillary thyroid cancer (PTC) evaluated at our institution between January 2008 and December 2011, 14 (0.23{\%}) had SVPTC and were analysed retrospectively. Results: Of the 14 patients with SVPTC, two were men and 12 were women, with a mean age of 48.2 years (range: 33-72 years). The mean follow-up period was 24 months (range: 8-36 months). All patients were assessed preoperatively by ultrasound-guided fine needle aspiration cytology (FNAC), with the diagnosis confirmed by permanent pathology and immunohistochemical staining performed by a specialized endocrine pathologist. Only one patient was diagnosed with SVPTC by preoperative FNAC, whereas 11 (78.6{\%}) were diagnosed with PTC or suspected of having PTC. The mean tumour size was 1.02 ± 0.30cm, with all tumours less than 2.0cm in diameter. The infiltrative tumour margins were observed in eight patients (57.1{\%}) and the extrathyroidal invasion in seven (50.0{\%}). The central lymph node metastases were found in five patients (35.7{\%}), and the lateral lymph node metastasis in one (7.1{\%}). No patient experienced tumour recurrence or distant metastasis during follow-up. Conclusions: Despite the small sample size and the short follow-up period, our results indicate that SVPTC may not be as aggressive a subtype as previously thought.",
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Chang, H, Kim, SM, Chun, KW, Kim, BW, Lee, YS, Chang, H-S, Hong, SW & Park, CS 2014, 'Clinicopathologic features of solid variant papillary thyroid cancer', ANZ Journal of Surgery, vol. 84, no. 5, pp. 380-382. https://doi.org/10.1111/ans.12307

Clinicopathologic features of solid variant papillary thyroid cancer. / Chang, Hojin; Kim, Seok Mo; Chun, Ki Won; Kim, Bup Woo; Lee, Yong Sang; Chang, Hang-Seok; Hong, Soon Won; Park, Cheong Soo.

In: ANZ Journal of Surgery, Vol. 84, No. 5, 01.01.2014, p. 380-382.

Research output: Contribution to journalArticle

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T1 - Clinicopathologic features of solid variant papillary thyroid cancer

AU - Chang, Hojin

AU - Kim, Seok Mo

AU - Chun, Ki Won

AU - Kim, Bup Woo

AU - Lee, Yong Sang

AU - Chang, Hang-Seok

AU - Hong, Soon Won

AU - Park, Cheong Soo

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: Solid variant papillary thyroid cancer (SVPTC) is a rare type of thyroid malignancy whose clinical characteristics remain poorly defined. Therefore, we evaluated the characteristics of 14 patients with SVPTC treated at our institution. Methods: Of the 6052 patients with papillary thyroid cancer (PTC) evaluated at our institution between January 2008 and December 2011, 14 (0.23%) had SVPTC and were analysed retrospectively. Results: Of the 14 patients with SVPTC, two were men and 12 were women, with a mean age of 48.2 years (range: 33-72 years). The mean follow-up period was 24 months (range: 8-36 months). All patients were assessed preoperatively by ultrasound-guided fine needle aspiration cytology (FNAC), with the diagnosis confirmed by permanent pathology and immunohistochemical staining performed by a specialized endocrine pathologist. Only one patient was diagnosed with SVPTC by preoperative FNAC, whereas 11 (78.6%) were diagnosed with PTC or suspected of having PTC. The mean tumour size was 1.02 ± 0.30cm, with all tumours less than 2.0cm in diameter. The infiltrative tumour margins were observed in eight patients (57.1%) and the extrathyroidal invasion in seven (50.0%). The central lymph node metastases were found in five patients (35.7%), and the lateral lymph node metastasis in one (7.1%). No patient experienced tumour recurrence or distant metastasis during follow-up. Conclusions: Despite the small sample size and the short follow-up period, our results indicate that SVPTC may not be as aggressive a subtype as previously thought.

AB - Background: Solid variant papillary thyroid cancer (SVPTC) is a rare type of thyroid malignancy whose clinical characteristics remain poorly defined. Therefore, we evaluated the characteristics of 14 patients with SVPTC treated at our institution. Methods: Of the 6052 patients with papillary thyroid cancer (PTC) evaluated at our institution between January 2008 and December 2011, 14 (0.23%) had SVPTC and were analysed retrospectively. Results: Of the 14 patients with SVPTC, two were men and 12 were women, with a mean age of 48.2 years (range: 33-72 years). The mean follow-up period was 24 months (range: 8-36 months). All patients were assessed preoperatively by ultrasound-guided fine needle aspiration cytology (FNAC), with the diagnosis confirmed by permanent pathology and immunohistochemical staining performed by a specialized endocrine pathologist. Only one patient was diagnosed with SVPTC by preoperative FNAC, whereas 11 (78.6%) were diagnosed with PTC or suspected of having PTC. The mean tumour size was 1.02 ± 0.30cm, with all tumours less than 2.0cm in diameter. The infiltrative tumour margins were observed in eight patients (57.1%) and the extrathyroidal invasion in seven (50.0%). The central lymph node metastases were found in five patients (35.7%), and the lateral lymph node metastasis in one (7.1%). No patient experienced tumour recurrence or distant metastasis during follow-up. Conclusions: Despite the small sample size and the short follow-up period, our results indicate that SVPTC may not be as aggressive a subtype as previously thought.

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DO - 10.1111/ans.12307

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