Clinicopathologic report of uveal melanoma with persistent exudative retinal detachment after gamma knife radiosurgery

Won Kyung Song, Woo Ick Yang, Suk Ho Byeon, Hyoung Jun Koh, Oh Woong Kwon, Sung Chul Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aims: Our purpose was to report the clinical and pathological findings from uveal melanoma patients with persistent exudative retinal detachment (RD) after Gamma Knife radiosurgery (GKR). Methods: A retrospective review was performed. Results: GKR was performed on 19 uveal melanoma patients from 2004 to 2006, and 5 of them developed persistent exudative RD. The mean initial largest basal tumor diameter in these 5 patients was 14.4 ± 1.9 mm, and the mean tumor height was 9.2 ± 1.0 mm. Marginal doses of 40-50 Gy radiation were administered. RD developed or had become aggravated an average of 3 (1-10) months after GKR. Two patients underwent enucleation, while the remaining 3 underwent tumor removal by endoresection with retinal reattachment surgery by vitrectomy and silicone oil tamponade. These procedures were undertaken an average of 6.3 (1.5-14) months after radiation and 3.3 (0.5-5) months after the onset or aggravation of RD. Histologically 4 tumors showed 50-100% necrosis without any mitotic activity. Thus local tumor control after GKR appeared sufficient regardless of RD. Conclusion: Aggravation or development of exudative RD after GKR does not necessarily entail treatment failure. Therefore, retinal reattachment surgery in persistent exudative RD may be an option to preserve the eye.

Original languageEnglish
Pages (from-to)16-21
Number of pages6
JournalOphthalmologica
Volume224
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

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Radiosurgery
Retinal Detachment
Neoplasms
Silicone Oils
Radiation Dosage
Vitrectomy
Uveal melanoma
Treatment Failure
Necrosis
Radiation

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems

Cite this

Song, Won Kyung ; Yang, Woo Ick ; Byeon, Suk Ho ; Koh, Hyoung Jun ; Kwon, Oh Woong ; Lee, Sung Chul. / Clinicopathologic report of uveal melanoma with persistent exudative retinal detachment after gamma knife radiosurgery. In: Ophthalmologica. 2009 ; Vol. 224, No. 1. pp. 16-21.
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Clinicopathologic report of uveal melanoma with persistent exudative retinal detachment after gamma knife radiosurgery. / Song, Won Kyung; Yang, Woo Ick; Byeon, Suk Ho; Koh, Hyoung Jun; Kwon, Oh Woong; Lee, Sung Chul.

In: Ophthalmologica, Vol. 224, No. 1, 01.01.2009, p. 16-21.

Research output: Contribution to journalArticle

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