Clinicopathologic Study of 8 Cases of Primary Cutaneous CD30-positive Cutaneous Large Cell Lymphoma

You Chan Kim, Min Geol Lee, Sang Kun Park, Woo Ick Yang, Kee Suck Suh

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Abstract

Background: Although several cases of primary cutaneous CD30-positive large cell lymphoma have been reported, immunohistochemical study on the tumor has not been reported in Korea. Objective: Our purpose is to evaluate the clinicopathologic and immunohistochemical findings of primary cutaneous CD30-positive large cell lymphoma. Methods: An immunohistochemical study was performed on paraffin sections of 8 primary cutaneous CD30-positive large cell lymphoma using CD3, CD45RO, CD45, CD20, CD30, and epithelial membrane antigen(EMA). Results: 1. Primary cutaneous CD30-positive large cell lymphoma occurred equally on males and females. The average age of the patients was 49. The lesion occurred most commonly as nodules on the extremities. Spontaneous regression occurred in 3 cases. The most common treatment was radiotherapy. 2. Histopathologically, 2 of 8 cases showed epidermal hyperplasia with intraepidermal neutrophils. Epidermotropism was found focally in 1 case. Inflammatory cells were present at the periphery of the lesions in 2 cases, but they were admixed with the large atypical cells in 1 case. Tumor cells invaded the subcutaneous tissue in 4 of 6 cases. 3. Immunohistochemically, the large anaplastic cells showed CD30 positivity. Tumor cells in all cases showed positivity for CD3, CD45RO, and CD45, but negative for CD20. Tumor cells stained with EMA in 1 of 6 cases. Conclusion: Primary cutaneous CD30-positive large cell lymphoma showed immunophenotype of T-cell lymphoma. It showed some clinicopathologic features of lymphomatoid papulosis, which suggests that both entities represent 2 ends(malignant and benign) of a spectrum of CD30-positive lymphoproliferative disorders. Therefore, for the diagnosis of primary cutaneous CD30-positive large cell lymphoma, all clinicopathologic and immunohistochemical findings should be considered together.

Original languageEnglish
Pages (from-to)1471-1477
Number of pages7
JournalKorean Journal of Dermatology
Volume41
Issue number11
Publication statusPublished - 2003 Nov 1

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Lymphoma
Skin
Mucin-1
Neoplasms
Lymphomatoid Papulosis
Lymphoproliferative Disorders
T-Cell Lymphoma
Subcutaneous Tissue
Korea
Paraffin
Hyperplasia
Neutrophils
Radiotherapy
Extremities

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Kim, You Chan ; Lee, Min Geol ; Park, Sang Kun ; Yang, Woo Ick ; Suh, Kee Suck. / Clinicopathologic Study of 8 Cases of Primary Cutaneous CD30-positive Cutaneous Large Cell Lymphoma. In: Korean Journal of Dermatology. 2003 ; Vol. 41, No. 11. pp. 1471-1477.
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abstract = "Background: Although several cases of primary cutaneous CD30-positive large cell lymphoma have been reported, immunohistochemical study on the tumor has not been reported in Korea. Objective: Our purpose is to evaluate the clinicopathologic and immunohistochemical findings of primary cutaneous CD30-positive large cell lymphoma. Methods: An immunohistochemical study was performed on paraffin sections of 8 primary cutaneous CD30-positive large cell lymphoma using CD3, CD45RO, CD45, CD20, CD30, and epithelial membrane antigen(EMA). Results: 1. Primary cutaneous CD30-positive large cell lymphoma occurred equally on males and females. The average age of the patients was 49. The lesion occurred most commonly as nodules on the extremities. Spontaneous regression occurred in 3 cases. The most common treatment was radiotherapy. 2. Histopathologically, 2 of 8 cases showed epidermal hyperplasia with intraepidermal neutrophils. Epidermotropism was found focally in 1 case. Inflammatory cells were present at the periphery of the lesions in 2 cases, but they were admixed with the large atypical cells in 1 case. Tumor cells invaded the subcutaneous tissue in 4 of 6 cases. 3. Immunohistochemically, the large anaplastic cells showed CD30 positivity. Tumor cells in all cases showed positivity for CD3, CD45RO, and CD45, but negative for CD20. Tumor cells stained with EMA in 1 of 6 cases. Conclusion: Primary cutaneous CD30-positive large cell lymphoma showed immunophenotype of T-cell lymphoma. It showed some clinicopathologic features of lymphomatoid papulosis, which suggests that both entities represent 2 ends(malignant and benign) of a spectrum of CD30-positive lymphoproliferative disorders. Therefore, for the diagnosis of primary cutaneous CD30-positive large cell lymphoma, all clinicopathologic and immunohistochemical findings should be considered together.",
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Clinicopathologic Study of 8 Cases of Primary Cutaneous CD30-positive Cutaneous Large Cell Lymphoma. / Kim, You Chan; Lee, Min Geol; Park, Sang Kun; Yang, Woo Ick; Suh, Kee Suck.

In: Korean Journal of Dermatology, Vol. 41, No. 11, 01.11.2003, p. 1471-1477.

Research output: Contribution to journalArticle

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T1 - Clinicopathologic Study of 8 Cases of Primary Cutaneous CD30-positive Cutaneous Large Cell Lymphoma

AU - Kim, You Chan

AU - Lee, Min Geol

AU - Park, Sang Kun

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AU - Suh, Kee Suck

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N2 - Background: Although several cases of primary cutaneous CD30-positive large cell lymphoma have been reported, immunohistochemical study on the tumor has not been reported in Korea. Objective: Our purpose is to evaluate the clinicopathologic and immunohistochemical findings of primary cutaneous CD30-positive large cell lymphoma. Methods: An immunohistochemical study was performed on paraffin sections of 8 primary cutaneous CD30-positive large cell lymphoma using CD3, CD45RO, CD45, CD20, CD30, and epithelial membrane antigen(EMA). Results: 1. Primary cutaneous CD30-positive large cell lymphoma occurred equally on males and females. The average age of the patients was 49. The lesion occurred most commonly as nodules on the extremities. Spontaneous regression occurred in 3 cases. The most common treatment was radiotherapy. 2. Histopathologically, 2 of 8 cases showed epidermal hyperplasia with intraepidermal neutrophils. Epidermotropism was found focally in 1 case. Inflammatory cells were present at the periphery of the lesions in 2 cases, but they were admixed with the large atypical cells in 1 case. Tumor cells invaded the subcutaneous tissue in 4 of 6 cases. 3. Immunohistochemically, the large anaplastic cells showed CD30 positivity. Tumor cells in all cases showed positivity for CD3, CD45RO, and CD45, but negative for CD20. Tumor cells stained with EMA in 1 of 6 cases. Conclusion: Primary cutaneous CD30-positive large cell lymphoma showed immunophenotype of T-cell lymphoma. It showed some clinicopathologic features of lymphomatoid papulosis, which suggests that both entities represent 2 ends(malignant and benign) of a spectrum of CD30-positive lymphoproliferative disorders. Therefore, for the diagnosis of primary cutaneous CD30-positive large cell lymphoma, all clinicopathologic and immunohistochemical findings should be considered together.

AB - Background: Although several cases of primary cutaneous CD30-positive large cell lymphoma have been reported, immunohistochemical study on the tumor has not been reported in Korea. Objective: Our purpose is to evaluate the clinicopathologic and immunohistochemical findings of primary cutaneous CD30-positive large cell lymphoma. Methods: An immunohistochemical study was performed on paraffin sections of 8 primary cutaneous CD30-positive large cell lymphoma using CD3, CD45RO, CD45, CD20, CD30, and epithelial membrane antigen(EMA). Results: 1. Primary cutaneous CD30-positive large cell lymphoma occurred equally on males and females. The average age of the patients was 49. The lesion occurred most commonly as nodules on the extremities. Spontaneous regression occurred in 3 cases. The most common treatment was radiotherapy. 2. Histopathologically, 2 of 8 cases showed epidermal hyperplasia with intraepidermal neutrophils. Epidermotropism was found focally in 1 case. Inflammatory cells were present at the periphery of the lesions in 2 cases, but they were admixed with the large atypical cells in 1 case. Tumor cells invaded the subcutaneous tissue in 4 of 6 cases. 3. Immunohistochemically, the large anaplastic cells showed CD30 positivity. Tumor cells in all cases showed positivity for CD3, CD45RO, and CD45, but negative for CD20. Tumor cells stained with EMA in 1 of 6 cases. Conclusion: Primary cutaneous CD30-positive large cell lymphoma showed immunophenotype of T-cell lymphoma. It showed some clinicopathologic features of lymphomatoid papulosis, which suggests that both entities represent 2 ends(malignant and benign) of a spectrum of CD30-positive lymphoproliferative disorders. Therefore, for the diagnosis of primary cutaneous CD30-positive large cell lymphoma, all clinicopathologic and immunohistochemical findings should be considered together.

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