Clinicopathologic study of Wegener's granulomatosis with special emphasis on early lesions in 10 Korean patients.

YongBeom Park, J. Y. Kim, J. A. Linton, H. J. Jung, S. K. Lee, D. H. Shin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We reviewed ten cases of Wegener's granulomatosis with special emphasis on the characteristics of the early stage of Wegener's granulomatosis. All patients presented with nonspecific symptoms and signs, so that Wegener's granulomatosis was not initially considered. However, half of the patients had clinical or radiologic disease in the nose/or paranasal sinuses as the primary presenting problems and showed neutrophil microabscess surrounded by palisading epithelioid cells and irregularly arranged giant cells in the nasal biopsy as the most characteristic feature. Five of ten patients were believed to have a protracted superficial phenomenon before involvement of other organs, specifically the lung or kidney. Four of ten patients showed nonreactivity to ANCA test at the time of presentation. Although the number of cases reviewed in this study was small, the rate of nonreactivity to ANCA was higher than those of the larger series. The importance of early diagnosis of Wegener's granulomatosis can not be overemphasized in view of the fact that cases unrecognized clinicopathologically finally progress to full-blown systemic form of Wegener's granulomatosis with poor prognosis. The diagnosis of Wegener's granulomatosis should be based on a thorough and meticulous examination of its characteristic histologic changes in biopsied tissue particularly extravascular foci.

Original languageEnglish
Pages (from-to)46-54
Number of pages9
JournalYonsei Medical Journal
Volume42
Issue number1
DOIs
Publication statusPublished - 2001 Jan 1

Fingerprint

Granulomatosis with Polyangiitis
Antineutrophil Cytoplasmic Antibodies
Nose Diseases
Epithelioid Cells
Paranasal Sinuses
Giant Cells
Nose
Signs and Symptoms
Early Diagnosis
Neutrophils
Kidney
Biopsy
Lung

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Park, YongBeom ; Kim, J. Y. ; Linton, J. A. ; Jung, H. J. ; Lee, S. K. ; Shin, D. H. / Clinicopathologic study of Wegener's granulomatosis with special emphasis on early lesions in 10 Korean patients. In: Yonsei Medical Journal. 2001 ; Vol. 42, No. 1. pp. 46-54.
@article{bb243696e7fc4de999594189f8e46db3,
title = "Clinicopathologic study of Wegener's granulomatosis with special emphasis on early lesions in 10 Korean patients.",
abstract = "We reviewed ten cases of Wegener's granulomatosis with special emphasis on the characteristics of the early stage of Wegener's granulomatosis. All patients presented with nonspecific symptoms and signs, so that Wegener's granulomatosis was not initially considered. However, half of the patients had clinical or radiologic disease in the nose/or paranasal sinuses as the primary presenting problems and showed neutrophil microabscess surrounded by palisading epithelioid cells and irregularly arranged giant cells in the nasal biopsy as the most characteristic feature. Five of ten patients were believed to have a protracted superficial phenomenon before involvement of other organs, specifically the lung or kidney. Four of ten patients showed nonreactivity to ANCA test at the time of presentation. Although the number of cases reviewed in this study was small, the rate of nonreactivity to ANCA was higher than those of the larger series. The importance of early diagnosis of Wegener's granulomatosis can not be overemphasized in view of the fact that cases unrecognized clinicopathologically finally progress to full-blown systemic form of Wegener's granulomatosis with poor prognosis. The diagnosis of Wegener's granulomatosis should be based on a thorough and meticulous examination of its characteristic histologic changes in biopsied tissue particularly extravascular foci.",
author = "YongBeom Park and Kim, {J. Y.} and Linton, {J. A.} and Jung, {H. J.} and Lee, {S. K.} and Shin, {D. H.}",
year = "2001",
month = "1",
day = "1",
doi = "10.3349/ymj.2001.42.1.46",
language = "English",
volume = "42",
pages = "46--54",
journal = "Yonsei Medical Journal",
issn = "0513-5796",
publisher = "Yonsei University College of Medicine",
number = "1",

}

Clinicopathologic study of Wegener's granulomatosis with special emphasis on early lesions in 10 Korean patients. / Park, YongBeom; Kim, J. Y.; Linton, J. A.; Jung, H. J.; Lee, S. K.; Shin, D. H.

In: Yonsei Medical Journal, Vol. 42, No. 1, 01.01.2001, p. 46-54.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinicopathologic study of Wegener's granulomatosis with special emphasis on early lesions in 10 Korean patients.

AU - Park, YongBeom

AU - Kim, J. Y.

AU - Linton, J. A.

AU - Jung, H. J.

AU - Lee, S. K.

AU - Shin, D. H.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - We reviewed ten cases of Wegener's granulomatosis with special emphasis on the characteristics of the early stage of Wegener's granulomatosis. All patients presented with nonspecific symptoms and signs, so that Wegener's granulomatosis was not initially considered. However, half of the patients had clinical or radiologic disease in the nose/or paranasal sinuses as the primary presenting problems and showed neutrophil microabscess surrounded by palisading epithelioid cells and irregularly arranged giant cells in the nasal biopsy as the most characteristic feature. Five of ten patients were believed to have a protracted superficial phenomenon before involvement of other organs, specifically the lung or kidney. Four of ten patients showed nonreactivity to ANCA test at the time of presentation. Although the number of cases reviewed in this study was small, the rate of nonreactivity to ANCA was higher than those of the larger series. The importance of early diagnosis of Wegener's granulomatosis can not be overemphasized in view of the fact that cases unrecognized clinicopathologically finally progress to full-blown systemic form of Wegener's granulomatosis with poor prognosis. The diagnosis of Wegener's granulomatosis should be based on a thorough and meticulous examination of its characteristic histologic changes in biopsied tissue particularly extravascular foci.

AB - We reviewed ten cases of Wegener's granulomatosis with special emphasis on the characteristics of the early stage of Wegener's granulomatosis. All patients presented with nonspecific symptoms and signs, so that Wegener's granulomatosis was not initially considered. However, half of the patients had clinical or radiologic disease in the nose/or paranasal sinuses as the primary presenting problems and showed neutrophil microabscess surrounded by palisading epithelioid cells and irregularly arranged giant cells in the nasal biopsy as the most characteristic feature. Five of ten patients were believed to have a protracted superficial phenomenon before involvement of other organs, specifically the lung or kidney. Four of ten patients showed nonreactivity to ANCA test at the time of presentation. Although the number of cases reviewed in this study was small, the rate of nonreactivity to ANCA was higher than those of the larger series. The importance of early diagnosis of Wegener's granulomatosis can not be overemphasized in view of the fact that cases unrecognized clinicopathologically finally progress to full-blown systemic form of Wegener's granulomatosis with poor prognosis. The diagnosis of Wegener's granulomatosis should be based on a thorough and meticulous examination of its characteristic histologic changes in biopsied tissue particularly extravascular foci.

UR - http://www.scopus.com/inward/record.url?scp=0035261012&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035261012&partnerID=8YFLogxK

U2 - 10.3349/ymj.2001.42.1.46

DO - 10.3349/ymj.2001.42.1.46

M3 - Article

VL - 42

SP - 46

EP - 54

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

SN - 0513-5796

IS - 1

ER -