Clinicopathological characteristics of metaplastic papillary tumor of the fallopian tube

Mi Jang, Ji Youn Sung, Ji Ye Kim, Hyunsoo Kim

Research output: Contribution to journalArticle

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Abstract

Metaplastic papillary tumor (MPT) of the fallopian tube is a very uncommon lesion, displaying papillary growth of bland-appearing cells with abundant, eosinophilic cytoplasm and mucinous metaplasia. It is difficult for pathologists to determine whether to categorize this lesion as a metaplastic proliferative lesion or a true neoplasm. We recently experienced a case of tubal MPT and initiated a comprehensive review of previously published cases with thorough analysis of clinicopathological characteristicS. MPT is typically related to pregnancy, but we describe the first case of pregnancy-unrelated, incidentally detected tubal MPT in a 51-year-old woman who underwent surgery for endometrial cancer. The MPT consisted of small papillary formations with epithelium consisting of nonciliated, columnar cells with abundant eosinophilic cytoplasm arranged as either a single layer or pseudostratified layer. The stroma had a myxoid appearance. Intraluminal and extracellular mucin and floating papillary tufts were observed. Nuclei of the epithelial lining cells were centrally located, rounded or oval, and displayed intranuclear pseudoinclusions or grooveS. The MPT cells were positive for paired box 8, epithelial membrane antigen, and cytokeratin. Interestingly, Wilms tumor 1 (WT1) protein was localized within the cytoplasm of MPT cellS. Furthermore, the MPT cells did not express phosphatase and tensin homolog deleted on chromosome 10 (PTEN). In summary, MPT of the fallopian tube is a very unusual, distinctive entity displaying unique histopathological features and immunophenotype. Our observation of cytoplasmic WT1 expression and loss of PTEN expression in tubal MPT suggests its neoplastic nature and raises the possibility of WT1 or PTEN involvement in the development of MPT.

Original languageEnglish
Pages (from-to)3693-3701
Number of pages9
JournalAnticancer research
Volume37
Issue number7
DOIs
Publication statusPublished - 2017 Jul 1

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Fallopian Tubes
Neoplasms
Wilms Tumor
Cytoplasm
Pregnancy
Mucin-1
Chromosomes, Human, Pair 10
Metaplasia
Mucins
Endometrial Neoplasms
Keratins
Phosphoric Monoester Hydrolases
Epithelium
Epithelial Cells
Observation

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Jang, Mi ; Sung, Ji Youn ; Kim, Ji Ye ; Kim, Hyunsoo. / Clinicopathological characteristics of metaplastic papillary tumor of the fallopian tube. In: Anticancer research. 2017 ; Vol. 37, No. 7. pp. 3693-3701.
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Clinicopathological characteristics of metaplastic papillary tumor of the fallopian tube. / Jang, Mi; Sung, Ji Youn; Kim, Ji Ye; Kim, Hyunsoo.

In: Anticancer research, Vol. 37, No. 7, 01.07.2017, p. 3693-3701.

Research output: Contribution to journalArticle

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