Clinicopathological characteristics of mucinous carcinoma of the breast in Korea: Comparison with invasive ductal carcinoma-not otherwise specified

Seho Park, JaSeung Koo, Joo Hee Kim, Woo Ick Yang, Byeongwoo Park, Kyong Sik Lee

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Clinicopathological characteristics and prognostic factors of mucinous carcinoma (MC) were compared with invasive ductal carcinoma-not otherwise specified (IDC-NOS). Clinicopathological characteristics and survivals of 104 MC patients were retrospectively reviewed and compared with those of 3,936 IDC-NOS. The median age at diagnosis was 45 yr in MC and 47 yr in IDC-NOS, respectively. The sensitivity of mammography and sonography for pure MC were 76.5% and 94.7%, respectively. MC showed favorable characteristics including less involvement of lymph node, lower stage, more expression of estrogen receptors, less HER-2 overexpression and differentiated grade, and better 10-yr disease-free survival (DFS) and overall survival (OS) (86.1% and 86.3%, respectively) than IDC-NOS (74.7% and 74.9%, respectively). Ten-year DFS of pure and mixed type was 90.2% and 68.8%, respectively. Nodal status and stage were statistically significant factors for survival. MC in Koreans showed similar features to Western populations except for a younger age of onset than in IDC-NOS. Since only pure MC showed better prognosis than IDC-NOS, it is important to differentiate mixed MC from pure MC. Middle-aged Korean women presenting breast symptoms should be examined carefully and evaluated with an appropriate diagnostic work-up because some patients present radio-logically benign-like lesions.

Original languageEnglish
Pages (from-to)361-368
Number of pages8
JournalJournal of Korean medical science
Volume25
Issue number3
DOIs
Publication statusPublished - 2010 Mar 1

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Mucinous Adenocarcinoma
Ductal Carcinoma
Korea
Breast
Disease-Free Survival
Survival
Mammography
Radio
Age of Onset
Estrogen Receptors
Ultrasonography
Lymph Nodes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Clinicopathological characteristics of mucinous carcinoma of the breast in Korea: Comparison with invasive ductal carcinoma-not otherwise specified",
abstract = "Clinicopathological characteristics and prognostic factors of mucinous carcinoma (MC) were compared with invasive ductal carcinoma-not otherwise specified (IDC-NOS). Clinicopathological characteristics and survivals of 104 MC patients were retrospectively reviewed and compared with those of 3,936 IDC-NOS. The median age at diagnosis was 45 yr in MC and 47 yr in IDC-NOS, respectively. The sensitivity of mammography and sonography for pure MC were 76.5{\%} and 94.7{\%}, respectively. MC showed favorable characteristics including less involvement of lymph node, lower stage, more expression of estrogen receptors, less HER-2 overexpression and differentiated grade, and better 10-yr disease-free survival (DFS) and overall survival (OS) (86.1{\%} and 86.3{\%}, respectively) than IDC-NOS (74.7{\%} and 74.9{\%}, respectively). Ten-year DFS of pure and mixed type was 90.2{\%} and 68.8{\%}, respectively. Nodal status and stage were statistically significant factors for survival. MC in Koreans showed similar features to Western populations except for a younger age of onset than in IDC-NOS. Since only pure MC showed better prognosis than IDC-NOS, it is important to differentiate mixed MC from pure MC. Middle-aged Korean women presenting breast symptoms should be examined carefully and evaluated with an appropriate diagnostic work-up because some patients present radio-logically benign-like lesions.",
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Clinicopathological characteristics of mucinous carcinoma of the breast in Korea : Comparison with invasive ductal carcinoma-not otherwise specified. / Park, Seho; Koo, JaSeung; Kim, Joo Hee; Yang, Woo Ick; Park, Byeongwoo; Lee, Kyong Sik.

In: Journal of Korean medical science, Vol. 25, No. 3, 01.03.2010, p. 361-368.

Research output: Contribution to journalArticle

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