Clinicopathological Characteristics of Pleomorphic High-Grade Squamous Intraepithelial Lesion of the Uterine Cervix: A Single-Institutional Series of 31 Cases

Hyunjin Kim; Sangjoon Choi; Sung Im Do; Sang Hwa Lee; Nara Yoon; Hyun Soo Kim

doi:10.3390/diagnostics10080595

Clinicopathological Characteristics of Pleomorphic High-Grade Squamous Intraepithelial Lesion of the Uterine Cervix: A Single-Institutional Series of 31 Cases

Hyunjin Kim, Sangjoon Choi, Sung Im Do, Sang Hwa Lee, Nara Yoon, Hyun Soo Kim

Department of Pathology

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We investigated the clinicopathological characteristics of 31 cases of pleomorphic high-grade squamous intraepithelial lesions (PHSIL) of the uterine cervix. We reviewed electronic medical records and all available slides to collect clinical and pathological information. PHSILs were histologically characterized by significant nuclear enlargement, marked pleomorphism, hyperchromasia, increased mitotic activity, and frequent atypical mitoses. In the majority of cases (24/31; 77.4%), this striking nuclear atypia involved both the surface epithelium and the endocervical glands. In the remaining seven cases, pleomorphic cells were observed in the surface epithelium only. PHSILs involving both the surface epithelium and glands showed higher mitotic counts and Ki-67 labelling indices than the surface-only PHSILs. Invasive squamous cell carcinoma was present in only one case (3.2%), and none developed recurrent disease. Our observations of striking nuclear atypia in cases of HSIL did not indicate increased aggressiveness. Further investigations are required for confirmation of our data in larger cohorts.

Original language	English
Article number	595
Journal	Diagnostics
Volume	10
Issue number	8
DOIs	https://doi.org/10.3390/diagnostics10080595
Publication status	Published - 2020 Aug

Bibliographical note

Funding Information:
Funding: This research was supported by a Grant of Translational R&D Project through the Institute for Bio-Medical Convergence (Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea) and by a grant from the National Research Foundation of Korea (NRF) funded by the Korean government (Ministry of Science and ICT) (2018R1C1B5043725).

Funding Information:
This research was supported by a Grant of Translational R&D Project through the Institute for Bio-Medical Convergence (Incheon St. Mary?s Hospital, College of Medicine, The Catholic University of Korea) and by a grant from the National Research Foundation of Korea (NRF) funded by the Korean government (Ministry of Science and ICT) (2018R1C1B5043725).

Publisher Copyright:
© 2020 by the authors.

All Science Journal Classification (ASJC) codes

Clinical Biochemistry

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10.3390/diagnostics10080595

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title = "Clinicopathological Characteristics of Pleomorphic High-Grade Squamous Intraepithelial Lesion of the Uterine Cervix: A Single-Institutional Series of 31 Cases",

abstract = "We investigated the clinicopathological characteristics of 31 cases of pleomorphic high-grade squamous intraepithelial lesions (PHSIL) of the uterine cervix. We reviewed electronic medical records and all available slides to collect clinical and pathological information. PHSILs were histologically characterized by significant nuclear enlargement, marked pleomorphism, hyperchromasia, increased mitotic activity, and frequent atypical mitoses. In the majority of cases (24/31; 77.4%), this striking nuclear atypia involved both the surface epithelium and the endocervical glands. In the remaining seven cases, pleomorphic cells were observed in the surface epithelium only. PHSILs involving both the surface epithelium and glands showed higher mitotic counts and Ki-67 labelling indices than the surface-only PHSILs. Invasive squamous cell carcinoma was present in only one case (3.2%), and none developed recurrent disease. Our observations of striking nuclear atypia in cases of HSIL did not indicate increased aggressiveness. Further investigations are required for confirmation of our data in larger cohorts.",

author = "Hyunjin Kim and Sangjoon Choi and Do, {Sung Im} and Lee, {Sang Hwa} and Nara Yoon and Kim, {Hyun Soo}",

note = "Funding Information: Funding: This research was supported by a Grant of Translational R&D Project through the Institute for Bio-Medical Convergence (Incheon St. Mary{\textquoteright}s Hospital, College of Medicine, The Catholic University of Korea) and by a grant from the National Research Foundation of Korea (NRF) funded by the Korean government (Ministry of Science and ICT) (2018R1C1B5043725). Funding Information: This research was supported by a Grant of Translational R&D Project through the Institute for Bio-Medical Convergence (Incheon St. Mary?s Hospital, College of Medicine, The Catholic University of Korea) and by a grant from the National Research Foundation of Korea (NRF) funded by the Korean government (Ministry of Science and ICT) (2018R1C1B5043725). Publisher Copyright: {\textcopyright} 2020 by the authors.",

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AU - Kim, Hyun Soo

N1 - Funding Information: Funding: This research was supported by a Grant of Translational R&D Project through the Institute for Bio-Medical Convergence (Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea) and by a grant from the National Research Foundation of Korea (NRF) funded by the Korean government (Ministry of Science and ICT) (2018R1C1B5043725). Funding Information: This research was supported by a Grant of Translational R&D Project through the Institute for Bio-Medical Convergence (Incheon St. Mary?s Hospital, College of Medicine, The Catholic University of Korea) and by a grant from the National Research Foundation of Korea (NRF) funded by the Korean government (Ministry of Science and ICT) (2018R1C1B5043725). Publisher Copyright: © 2020 by the authors.

PY - 2020/8

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N2 - We investigated the clinicopathological characteristics of 31 cases of pleomorphic high-grade squamous intraepithelial lesions (PHSIL) of the uterine cervix. We reviewed electronic medical records and all available slides to collect clinical and pathological information. PHSILs were histologically characterized by significant nuclear enlargement, marked pleomorphism, hyperchromasia, increased mitotic activity, and frequent atypical mitoses. In the majority of cases (24/31; 77.4%), this striking nuclear atypia involved both the surface epithelium and the endocervical glands. In the remaining seven cases, pleomorphic cells were observed in the surface epithelium only. PHSILs involving both the surface epithelium and glands showed higher mitotic counts and Ki-67 labelling indices than the surface-only PHSILs. Invasive squamous cell carcinoma was present in only one case (3.2%), and none developed recurrent disease. Our observations of striking nuclear atypia in cases of HSIL did not indicate increased aggressiveness. Further investigations are required for confirmation of our data in larger cohorts.

AB - We investigated the clinicopathological characteristics of 31 cases of pleomorphic high-grade squamous intraepithelial lesions (PHSIL) of the uterine cervix. We reviewed electronic medical records and all available slides to collect clinical and pathological information. PHSILs were histologically characterized by significant nuclear enlargement, marked pleomorphism, hyperchromasia, increased mitotic activity, and frequent atypical mitoses. In the majority of cases (24/31; 77.4%), this striking nuclear atypia involved both the surface epithelium and the endocervical glands. In the remaining seven cases, pleomorphic cells were observed in the surface epithelium only. PHSILs involving both the surface epithelium and glands showed higher mitotic counts and Ki-67 labelling indices than the surface-only PHSILs. Invasive squamous cell carcinoma was present in only one case (3.2%), and none developed recurrent disease. Our observations of striking nuclear atypia in cases of HSIL did not indicate increased aggressiveness. Further investigations are required for confirmation of our data in larger cohorts.

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Clinicopathological Characteristics of Pleomorphic High-Grade Squamous Intraepithelial Lesion of the Uterine Cervix: A Single-Institutional Series of 31 Cases

Abstract

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