Background/Aims: Primary colorectal signet-ring cell carcinoma (SRC) is a rare type of mucin-containing adenocarcinoma and little information exists about its clinicopathological features. Methods: The clinicopathological features of 27 patients with primary colorectal SRC were compared with non-signet-ring cell mucinous carcinoma (MC) and non-mucinous adenocarcinoma (NMC). To analyze survival and recurrence, we used matched control groups. Results: The mean age of patients in SRC was significantly younger than that of NMC (p=0.003). The ratio of metastatic lymph nodes to harvested lymph nodes was also significantly higher in SRC (48.5±30.6) than in either MC (29.8±26.3; p=0.009) or NMC (22.0±21.6; p=0.003). In stage II and III, SRC was found to be associated with a worse cancer-specific survival and a higher systemic recurrence rates than either NMC or MC. Conclusions: Primary colorectal SRC has distinctive clinicopathological features and is associated with a poorer prognosis than the other histological subtypes.
|Number of pages||5|
|Publication status||Published - 2009 Jul|
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