Clinicopathological features of signet-ring cell carcinoma of the colon and rectum: A case-matched study

Byung Soh Min, Nam Kyu Kim, Yong Taek Ko, Seung Hyuk Baek, Kang Young Lee, Seung Kook Sohn, Chang Hwan Cho, Dae Ryong Kang

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10 Citations (Scopus)

Abstract

Background/Aims: Primary colorectal signet-ring cell carcinoma (SRC) is a rare type of mucin-containing adenocarcinoma and little information exists about its clinicopathological features. Methods: The clinicopathological features of 27 patients with primary colorectal SRC were compared with non-signet-ring cell mucinous carcinoma (MC) and non-mucinous adenocarcinoma (NMC). To analyze survival and recurrence, we used matched control groups. Results: The mean age of patients in SRC was significantly younger than that of NMC (p=0.003). The ratio of metastatic lymph nodes to harvested lymph nodes was also significantly higher in SRC (48.5±30.6) than in either MC (29.8±26.3; p=0.009) or NMC (22.0±21.6; p=0.003). In stage II and III, SRC was found to be associated with a worse cancer-specific survival and a higher systemic recurrence rates than either NMC or MC. Conclusions: Primary colorectal SRC has distinctive clinicopathological features and is associated with a poorer prognosis than the other histological subtypes.

Original languageEnglish
Pages (from-to)984-988
Number of pages5
JournalHepato-gastroenterology
Volume56
Issue number93
Publication statusPublished - 2009 Jul

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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    Min, B. S., Kim, N. K., Ko, Y. T., Baek, S. H., Lee, K. Y., Sohn, S. K., Cho, C. H., & Kang, D. R. (2009). Clinicopathological features of signet-ring cell carcinoma of the colon and rectum: A case-matched study. Hepato-gastroenterology, 56(93), 984-988.