Clusterin is highly expressed in tubular complexes during spontaneous pancreatitis of spontaneous hypertensive rats

Jun Won Park, Ki Taek Nam, Jae Hoon Shin, Il Yong Kim, Kyung Mi Choi, Kyung Jin Roh, Seung Hyun Oh, Young Min Yun, Jun Gyo Suh, Yang Seok Oh, Yeo Sung Yoon, Je Kyung Seong

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Abstract

Pancreatitis is an inflammatory disorder of pancreas which leads to varying degrees of pancreatic endocrine and exocrine dysfunction and manifests in either acute or chronic forms. Spontaneous pancreatitis in experimental animals has rarely been reported. Here, we found acute to chronic courses of spontaneous pancreatitis in spontaneously hypertensive rats (SHRs), showing the formation of tubular complexes (TCs) and enhanced islet regeneration. We investigated the expression pattern of clusterin in the pancreas of SHRs based on immunohistochemistry (IHC). IHC analysis revealed the strong expression of clusterin in dedifferentiated duct-like cells and regenerative islets of TCs. These results imply that clusterin might be involved in the formation of TCs and parenchymal regeneration during rat pancreatitis.

Original languageEnglish
Pages (from-to)1553-1557
Number of pages5
JournalJournal of Veterinary Medical Science
Volume80
Issue number10
DOIs
Publication statusPublished - 2018 Jan 1

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All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Park, J. W., Nam, K. T., Shin, J. H., Kim, I. Y., Choi, K. M., Roh, K. J., Oh, S. H., Yun, Y. M., Suh, J. G., Oh, Y. S., Yoon, Y. S., & Seong, J. K. (2018). Clusterin is highly expressed in tubular complexes during spontaneous pancreatitis of spontaneous hypertensive rats. Journal of Veterinary Medical Science, 80(10), 1553-1557. https://doi.org/10.1292/jvms.18-0205