Clusterin is highly expressed in tubular complexes during spontaneous pancreatitis of spontaneous hypertensive rats

Jun Won Park; Ki Taek Nam; Jae Hoon Shin; Il Yong Kim; Kyung Mi Choi; Kyung Jin Roh; Seung Hyun Oh; Young Min Yun; Jun Gyo Suh; Yang Seok Oh; Yeo Sung Yoon; Je Kyung Seong

doi:10.1292/jvms.18-0205

Clusterin is highly expressed in tubular complexes during spontaneous pancreatitis of spontaneous hypertensive rats

Jun Won Park, Ki Taek Nam, Jae Hoon Shin, Il Yong Kim, Kyung Mi Choi, Kyung Jin Roh, Seung Hyun Oh, Young Min Yun, Jun Gyo Suh, Yang Seok Oh, Yeo Sung Yoon, Je Kyung Seong

BioMedical Science Institute

Research output: Contribution to journal › Article › peer-review

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Abstract

Pancreatitis is an inflammatory disorder of pancreas which leads to varying degrees of pancreatic endocrine and exocrine dysfunction and manifests in either acute or chronic forms. Spontaneous pancreatitis in experimental animals has rarely been reported. Here, we found acute to chronic courses of spontaneous pancreatitis in spontaneously hypertensive rats (SHRs), showing the formation of tubular complexes (TCs) and enhanced islet regeneration. We investigated the expression pattern of clusterin in the pancreas of SHRs based on immunohistochemistry (IHC). IHC analysis revealed the strong expression of clusterin in dedifferentiated duct-like cells and regenerative islets of TCs. These results imply that clusterin might be involved in the formation of TCs and parenchymal regeneration during rat pancreatitis.

Original language	English
Pages (from-to)	1553-1557
Number of pages	5
Journal	Journal of Veterinary Medical Science
Volume	80
Issue number	10
DOIs	https://doi.org/10.1292/jvms.18-0205
Publication status	Published - 2018

Bibliographical note

Funding Information:
This work was supported by grants from the Brain Korea 21 Program for Veterinary Science and the Research Institute for Veterinary Science of Seoul National University and Korea Mouse Phenotyping Project (2013M3A9D5072550) of the Ministry of Science, ICT and Future Planning through the National Research Foundation. The funders had no role in study design, data collection and analysis, or preparation of the manuscript.

Funding Information:
ACKNOWLEDGMENTS. This work was supported by grants from the Brain Korea 21 Program for Veterinary Science and the Research Institute for Veterinary Science of Seoul National University and Korea Mouse Phenotyping Project (2013M3A9D5072550) of the Ministry of Science, ICT and Future Planning through the National Research Foundation. The funders had no role in study

Publisher Copyright:
© 2018 The Japanese Society of Veterinary Science.

All Science Journal Classification (ASJC) codes

veterinary(all)

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10.1292/jvms.18-0205

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title = "Clusterin is highly expressed in tubular complexes during spontaneous pancreatitis of spontaneous hypertensive rats",

abstract = "Pancreatitis is an inflammatory disorder of pancreas which leads to varying degrees of pancreatic endocrine and exocrine dysfunction and manifests in either acute or chronic forms. Spontaneous pancreatitis in experimental animals has rarely been reported. Here, we found acute to chronic courses of spontaneous pancreatitis in spontaneously hypertensive rats (SHRs), showing the formation of tubular complexes (TCs) and enhanced islet regeneration. We investigated the expression pattern of clusterin in the pancreas of SHRs based on immunohistochemistry (IHC). IHC analysis revealed the strong expression of clusterin in dedifferentiated duct-like cells and regenerative islets of TCs. These results imply that clusterin might be involved in the formation of TCs and parenchymal regeneration during rat pancreatitis.",

author = "Park, {Jun Won} and Nam, {Ki Taek} and Shin, {Jae Hoon} and Kim, {Il Yong} and Choi, {Kyung Mi} and Roh, {Kyung Jin} and Oh, {Seung Hyun} and Yun, {Young Min} and Suh, {Jun Gyo} and Oh, {Yang Seok} and Yoon, {Yeo Sung} and Seong, {Je Kyung}",

note = "Funding Information: This work was supported by grants from the Brain Korea 21 Program for Veterinary Science and the Research Institute for Veterinary Science of Seoul National University and Korea Mouse Phenotyping Project (2013M3A9D5072550) of the Ministry of Science, ICT and Future Planning through the National Research Foundation. The funders had no role in study design, data collection and analysis, or preparation of the manuscript. Funding Information: ACKNOWLEDGMENTS. This work was supported by grants from the Brain Korea 21 Program for Veterinary Science and the Research Institute for Veterinary Science of Seoul National University and Korea Mouse Phenotyping Project (2013M3A9D5072550) of the Ministry of Science, ICT and Future Planning through the National Research Foundation. The funders had no role in study Publisher Copyright: {\textcopyright} 2018 The Japanese Society of Veterinary Science.",

year = "2018",

doi = "10.1292/jvms.18-0205",

language = "English",

volume = "80",

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AU - Park, Jun Won

AU - Nam, Ki Taek

AU - Shin, Jae Hoon

AU - Kim, Il Yong

AU - Choi, Kyung Mi

AU - Roh, Kyung Jin

AU - Oh, Seung Hyun

AU - Yun, Young Min

AU - Suh, Jun Gyo

AU - Oh, Yang Seok

AU - Yoon, Yeo Sung

AU - Seong, Je Kyung

N1 - Funding Information: This work was supported by grants from the Brain Korea 21 Program for Veterinary Science and the Research Institute for Veterinary Science of Seoul National University and Korea Mouse Phenotyping Project (2013M3A9D5072550) of the Ministry of Science, ICT and Future Planning through the National Research Foundation. The funders had no role in study design, data collection and analysis, or preparation of the manuscript. Funding Information: ACKNOWLEDGMENTS. This work was supported by grants from the Brain Korea 21 Program for Veterinary Science and the Research Institute for Veterinary Science of Seoul National University and Korea Mouse Phenotyping Project (2013M3A9D5072550) of the Ministry of Science, ICT and Future Planning through the National Research Foundation. The funders had no role in study Publisher Copyright: © 2018 The Japanese Society of Veterinary Science.

PY - 2018

Y1 - 2018

N2 - Pancreatitis is an inflammatory disorder of pancreas which leads to varying degrees of pancreatic endocrine and exocrine dysfunction and manifests in either acute or chronic forms. Spontaneous pancreatitis in experimental animals has rarely been reported. Here, we found acute to chronic courses of spontaneous pancreatitis in spontaneously hypertensive rats (SHRs), showing the formation of tubular complexes (TCs) and enhanced islet regeneration. We investigated the expression pattern of clusterin in the pancreas of SHRs based on immunohistochemistry (IHC). IHC analysis revealed the strong expression of clusterin in dedifferentiated duct-like cells and regenerative islets of TCs. These results imply that clusterin might be involved in the formation of TCs and parenchymal regeneration during rat pancreatitis.

AB - Pancreatitis is an inflammatory disorder of pancreas which leads to varying degrees of pancreatic endocrine and exocrine dysfunction and manifests in either acute or chronic forms. Spontaneous pancreatitis in experimental animals has rarely been reported. Here, we found acute to chronic courses of spontaneous pancreatitis in spontaneously hypertensive rats (SHRs), showing the formation of tubular complexes (TCs) and enhanced islet regeneration. We investigated the expression pattern of clusterin in the pancreas of SHRs based on immunohistochemistry (IHC). IHC analysis revealed the strong expression of clusterin in dedifferentiated duct-like cells and regenerative islets of TCs. These results imply that clusterin might be involved in the formation of TCs and parenchymal regeneration during rat pancreatitis.

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Clusterin is highly expressed in tubular complexes during spontaneous pancreatitis of spontaneous hypertensive rats

Abstract

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