Clusterin is highly expressed in tubular complexes during spontaneous pancreatitis of spontaneous hypertensive rats

Jun Won Park, KiTaek Nam, Jae Hoon Shin, Il Yong Kim, Kyung Mi Choi, Kyung Jin Roh, Seung Hyun Oh, Young Min Yun, Jun Gyo Suh, Yang Seok Oh, Yeo Sung Yoon, Je Kyung Seong

Research output: Contribution to journalArticle

Abstract

Pancreatitis is an inflammatory disorder of pancreas which leads to varying degrees of pancreatic endocrine and exocrine dysfunction and manifests in either acute or chronic forms. Spontaneous pancreatitis in experimental animals has rarely been reported. Here, we found acute to chronic courses of spontaneous pancreatitis in spontaneously hypertensive rats (SHRs), showing the formation of tubular complexes (TCs) and enhanced islet regeneration. We investigated the expression pattern of clusterin in the pancreas of SHRs based on immunohistochemistry (IHC). IHC analysis revealed the strong expression of clusterin in dedifferentiated duct-like cells and regenerative islets of TCs. These results imply that clusterin might be involved in the formation of TCs and parenchymal regeneration during rat pancreatitis.

Original languageEnglish
Pages (from-to)1553-1557
Number of pages5
JournalThe Journal of veterinary medical science
Volume80
Issue number10
DOIs
Publication statusPublished - 2018 Nov 1

Fingerprint

Clusterin
pancreatitis
Pancreatitis
rats
Inbred SHR Rats
immunohistochemistry
Regeneration
Pancreas
Immunohistochemistry
pancreatic diseases
Islets of Langerhans
chronic diseases
pancreas
laboratory animals
cells

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Park, Jun Won ; Nam, KiTaek ; Shin, Jae Hoon ; Kim, Il Yong ; Choi, Kyung Mi ; Roh, Kyung Jin ; Oh, Seung Hyun ; Yun, Young Min ; Suh, Jun Gyo ; Oh, Yang Seok ; Yoon, Yeo Sung ; Seong, Je Kyung. / Clusterin is highly expressed in tubular complexes during spontaneous pancreatitis of spontaneous hypertensive rats. In: The Journal of veterinary medical science. 2018 ; Vol. 80, No. 10. pp. 1553-1557.
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abstract = "Pancreatitis is an inflammatory disorder of pancreas which leads to varying degrees of pancreatic endocrine and exocrine dysfunction and manifests in either acute or chronic forms. Spontaneous pancreatitis in experimental animals has rarely been reported. Here, we found acute to chronic courses of spontaneous pancreatitis in spontaneously hypertensive rats (SHRs), showing the formation of tubular complexes (TCs) and enhanced islet regeneration. We investigated the expression pattern of clusterin in the pancreas of SHRs based on immunohistochemistry (IHC). IHC analysis revealed the strong expression of clusterin in dedifferentiated duct-like cells and regenerative islets of TCs. These results imply that clusterin might be involved in the formation of TCs and parenchymal regeneration during rat pancreatitis.",
author = "Park, {Jun Won} and KiTaek Nam and Shin, {Jae Hoon} and Kim, {Il Yong} and Choi, {Kyung Mi} and Roh, {Kyung Jin} and Oh, {Seung Hyun} and Yun, {Young Min} and Suh, {Jun Gyo} and Oh, {Yang Seok} and Yoon, {Yeo Sung} and Seong, {Je Kyung}",
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Park, JW, Nam, K, Shin, JH, Kim, IY, Choi, KM, Roh, KJ, Oh, SH, Yun, YM, Suh, JG, Oh, YS, Yoon, YS & Seong, JK 2018, 'Clusterin is highly expressed in tubular complexes during spontaneous pancreatitis of spontaneous hypertensive rats', The Journal of veterinary medical science, vol. 80, no. 10, pp. 1553-1557. https://doi.org/10.1292/jvms.18-0205

Clusterin is highly expressed in tubular complexes during spontaneous pancreatitis of spontaneous hypertensive rats. / Park, Jun Won; Nam, KiTaek; Shin, Jae Hoon; Kim, Il Yong; Choi, Kyung Mi; Roh, Kyung Jin; Oh, Seung Hyun; Yun, Young Min; Suh, Jun Gyo; Oh, Yang Seok; Yoon, Yeo Sung; Seong, Je Kyung.

In: The Journal of veterinary medical science, Vol. 80, No. 10, 01.11.2018, p. 1553-1557.

Research output: Contribution to journalArticle

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AU - Park, Jun Won

AU - Nam, KiTaek

AU - Shin, Jae Hoon

AU - Kim, Il Yong

AU - Choi, Kyung Mi

AU - Roh, Kyung Jin

AU - Oh, Seung Hyun

AU - Yun, Young Min

AU - Suh, Jun Gyo

AU - Oh, Yang Seok

AU - Yoon, Yeo Sung

AU - Seong, Je Kyung

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