CNBP controls tumor cell biology by regulating tumor-promoting gene expression

Eunhye Lee, Taeyun A. Lee, Hye Jin Yoo, Sungwook Lee, Boyoun Park

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Cellular nucleic acid-binding protein (CNBP) is associated with cell proliferation, and its expression is elevated in human tumors, but the molecular mechanisms of CNBP in tumor cell biology have not been fully elucidated. In this study, we report that CNBP is a transcription factor essential for regulating matrix metalloproteinases mmp-2, mmp-14, and transcription factor e2f2 gene expression by binding to their promoter regions via a sequence-specific manner. Importantly, epidermal growth factor stimulation is required to induce CNBP phosphorylation and nuclear transport, thereby promoting the expression of mmp-2, mmp-14, and e2f2 genes. As a consequence, loss of cnbp attenuates the ability of tumor cell growth, invasion, and migration. Conversely, overexpression of cnbp is associated with tumor cell biology. Collectively, our findings reveal CNBP as a key transcriptional regulator of tumor-promoting target genes to control tumor cell biology.

Original languageEnglish
Pages (from-to)1492-1501
Number of pages10
JournalMolecular Carcinogenesis
Volume58
Issue number8
DOIs
Publication statusPublished - 2019 Aug

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cancer Research

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