Co-expression patterns of Notch1, Snail, and p53 in grade III hepatocellular carcinoma with postoperative recurrence

a preliminary study.

Sun Kyung Jang, Gi Hong Choi, Junjeong Choi, Xiaoyuan Quan, Jeong Won Jang, Bo Hyun Kim, Guhung Jung, Young Min Park

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We aimed to determine the association between the co-expression patterns of Notch1, Snail, and p53 proteins (NSP) and the postoperative prognosis of hepatocellular carcinoma (HCC). The immunoblot data for molecular expression (147 HCC/corresponding non-HCC tissues and 15 dysplastic nodules) and the sequencing data for p53 mutations (110 HCCs) were obtained from our previous study. Data analyses were restricted to cases with HCC differentiation grade III (n=47), due to its high p53 mutation rate. Nineteen of the 47 patients (40.4%) -comprising 12 in the liver and 7 in distant organs-had relapsed at 1-2 years after surgery. There was no relationship between p53 mutation and postoperative recurrence in the grade III HCCs. Seven (87.5%) of the eight relapsed cases with Notch1, Snail, and p53 (wild) co-expression experienced recurrence only within the liver, and all tumors were smaller than 5 cm in diameter. Extrahepatic relapse occurred mostly in HCC patients with tumors larger than 5 cm in diameter, without any deviation in the NSP pattern. The results of this preliminary study suggest that the co-expression of Notch1, Snail, and p53 (wild) is not inferior to the patterns with p53 mutation as an indicator of postoperative recurrence of grade III HCC.

Original languageEnglish
Pages (from-to)63-74
Number of pages12
JournalThe Korean journal of hepatology
Volume18
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

Fingerprint

Hepatocellular Carcinoma
Recurrence
Mutation
Liver
Mutation Rate
Neoplasms
Proteins
Carcinoma

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Jang, Sun Kyung ; Choi, Gi Hong ; Choi, Junjeong ; Quan, Xiaoyuan ; Jang, Jeong Won ; Kim, Bo Hyun ; Jung, Guhung ; Park, Young Min. / Co-expression patterns of Notch1, Snail, and p53 in grade III hepatocellular carcinoma with postoperative recurrence : a preliminary study. In: The Korean journal of hepatology. 2012 ; Vol. 18, No. 1. pp. 63-74.
@article{d2aca776f27b4347b2e613588fe3ba19,
title = "Co-expression patterns of Notch1, Snail, and p53 in grade III hepatocellular carcinoma with postoperative recurrence: a preliminary study.",
abstract = "We aimed to determine the association between the co-expression patterns of Notch1, Snail, and p53 proteins (NSP) and the postoperative prognosis of hepatocellular carcinoma (HCC). The immunoblot data for molecular expression (147 HCC/corresponding non-HCC tissues and 15 dysplastic nodules) and the sequencing data for p53 mutations (110 HCCs) were obtained from our previous study. Data analyses were restricted to cases with HCC differentiation grade III (n=47), due to its high p53 mutation rate. Nineteen of the 47 patients (40.4{\%}) -comprising 12 in the liver and 7 in distant organs-had relapsed at 1-2 years after surgery. There was no relationship between p53 mutation and postoperative recurrence in the grade III HCCs. Seven (87.5{\%}) of the eight relapsed cases with Notch1, Snail, and p53 (wild) co-expression experienced recurrence only within the liver, and all tumors were smaller than 5 cm in diameter. Extrahepatic relapse occurred mostly in HCC patients with tumors larger than 5 cm in diameter, without any deviation in the NSP pattern. The results of this preliminary study suggest that the co-expression of Notch1, Snail, and p53 (wild) is not inferior to the patterns with p53 mutation as an indicator of postoperative recurrence of grade III HCC.",
author = "Jang, {Sun Kyung} and Choi, {Gi Hong} and Junjeong Choi and Xiaoyuan Quan and Jang, {Jeong Won} and Kim, {Bo Hyun} and Guhung Jung and Park, {Young Min}",
year = "2012",
month = "1",
day = "1",
doi = "10.3350/kjhep.2012.18.1.63",
language = "English",
volume = "18",
pages = "63--74",
journal = "Clinical and molecular hepatology",
issn = "2287-2728",
publisher = "Korean Association for the Study of the Liver",
number = "1",

}

Co-expression patterns of Notch1, Snail, and p53 in grade III hepatocellular carcinoma with postoperative recurrence : a preliminary study. / Jang, Sun Kyung; Choi, Gi Hong; Choi, Junjeong; Quan, Xiaoyuan; Jang, Jeong Won; Kim, Bo Hyun; Jung, Guhung; Park, Young Min.

In: The Korean journal of hepatology, Vol. 18, No. 1, 01.01.2012, p. 63-74.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Co-expression patterns of Notch1, Snail, and p53 in grade III hepatocellular carcinoma with postoperative recurrence

T2 - a preliminary study.

AU - Jang, Sun Kyung

AU - Choi, Gi Hong

AU - Choi, Junjeong

AU - Quan, Xiaoyuan

AU - Jang, Jeong Won

AU - Kim, Bo Hyun

AU - Jung, Guhung

AU - Park, Young Min

PY - 2012/1/1

Y1 - 2012/1/1

N2 - We aimed to determine the association between the co-expression patterns of Notch1, Snail, and p53 proteins (NSP) and the postoperative prognosis of hepatocellular carcinoma (HCC). The immunoblot data for molecular expression (147 HCC/corresponding non-HCC tissues and 15 dysplastic nodules) and the sequencing data for p53 mutations (110 HCCs) were obtained from our previous study. Data analyses were restricted to cases with HCC differentiation grade III (n=47), due to its high p53 mutation rate. Nineteen of the 47 patients (40.4%) -comprising 12 in the liver and 7 in distant organs-had relapsed at 1-2 years after surgery. There was no relationship between p53 mutation and postoperative recurrence in the grade III HCCs. Seven (87.5%) of the eight relapsed cases with Notch1, Snail, and p53 (wild) co-expression experienced recurrence only within the liver, and all tumors were smaller than 5 cm in diameter. Extrahepatic relapse occurred mostly in HCC patients with tumors larger than 5 cm in diameter, without any deviation in the NSP pattern. The results of this preliminary study suggest that the co-expression of Notch1, Snail, and p53 (wild) is not inferior to the patterns with p53 mutation as an indicator of postoperative recurrence of grade III HCC.

AB - We aimed to determine the association between the co-expression patterns of Notch1, Snail, and p53 proteins (NSP) and the postoperative prognosis of hepatocellular carcinoma (HCC). The immunoblot data for molecular expression (147 HCC/corresponding non-HCC tissues and 15 dysplastic nodules) and the sequencing data for p53 mutations (110 HCCs) were obtained from our previous study. Data analyses were restricted to cases with HCC differentiation grade III (n=47), due to its high p53 mutation rate. Nineteen of the 47 patients (40.4%) -comprising 12 in the liver and 7 in distant organs-had relapsed at 1-2 years after surgery. There was no relationship between p53 mutation and postoperative recurrence in the grade III HCCs. Seven (87.5%) of the eight relapsed cases with Notch1, Snail, and p53 (wild) co-expression experienced recurrence only within the liver, and all tumors were smaller than 5 cm in diameter. Extrahepatic relapse occurred mostly in HCC patients with tumors larger than 5 cm in diameter, without any deviation in the NSP pattern. The results of this preliminary study suggest that the co-expression of Notch1, Snail, and p53 (wild) is not inferior to the patterns with p53 mutation as an indicator of postoperative recurrence of grade III HCC.

UR - http://www.scopus.com/inward/record.url?scp=84864871907&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864871907&partnerID=8YFLogxK

U2 - 10.3350/kjhep.2012.18.1.63

DO - 10.3350/kjhep.2012.18.1.63

M3 - Article

VL - 18

SP - 63

EP - 74

JO - Clinical and molecular hepatology

JF - Clinical and molecular hepatology

SN - 2287-2728

IS - 1

ER -