Abstract
Cochlioquinone A1 (CoA1) was newly isolated from the culture extract of Bipolaris zeicola as a potent anti-angiogenic agent. CoA1 inhibited in vitro angiogenesis of bovine aortic endothelial cells (BAECs) such as bFGF-induced tube formation and invasion at the concentration (1 μg/mL) without cytotoxicity. Notably, CoA1 exhibited more potent inhibition activity for the growth of BAECs than that of normal and cancer cell lines investigated in this study. These results demonstrate that CoA1 is a new anti-angiogenic agent and can be developed as a new therapeutic agent for angiogenesis-related diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 4743-4747 |
| Number of pages | 5 |
| Journal | Bioorganic and Medicinal Chemistry |
| Volume | 11 |
| Issue number | 22 |
| DOIs | |
| Publication status | Published - 2003 Nov 1 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
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Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola. / Jung, Hye Jin; Lee, Hyang Burm; Lim, Chi Hwan; Kim, Chang Jin; Kwon, Ho Jeong.
In: Bioorganic and Medicinal Chemistry, Vol. 11, No. 22, 01.11.2003, p. 4743-4747.Research output: Contribution to journal › Article
TY - JOUR
T1 - Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola
AU - Jung, Hye Jin
AU - Lee, Hyang Burm
AU - Lim, Chi Hwan
AU - Kim, Chang Jin
AU - Kwon, Ho Jeong
PY - 2003/11/1
Y1 - 2003/11/1
N2 - Cochlioquinone A1 (CoA1) was newly isolated from the culture extract of Bipolaris zeicola as a potent anti-angiogenic agent. CoA1 inhibited in vitro angiogenesis of bovine aortic endothelial cells (BAECs) such as bFGF-induced tube formation and invasion at the concentration (1 μg/mL) without cytotoxicity. Notably, CoA1 exhibited more potent inhibition activity for the growth of BAECs than that of normal and cancer cell lines investigated in this study. These results demonstrate that CoA1 is a new anti-angiogenic agent and can be developed as a new therapeutic agent for angiogenesis-related diseases.
AB - Cochlioquinone A1 (CoA1) was newly isolated from the culture extract of Bipolaris zeicola as a potent anti-angiogenic agent. CoA1 inhibited in vitro angiogenesis of bovine aortic endothelial cells (BAECs) such as bFGF-induced tube formation and invasion at the concentration (1 μg/mL) without cytotoxicity. Notably, CoA1 exhibited more potent inhibition activity for the growth of BAECs than that of normal and cancer cell lines investigated in this study. These results demonstrate that CoA1 is a new anti-angiogenic agent and can be developed as a new therapeutic agent for angiogenesis-related diseases.
UR - http://www.scopus.com/inward/record.url?scp=0141923190&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0141923190&partnerID=8YFLogxK
U2 - 10.1016/S0968-0896(03)00523-6
DO - 10.1016/S0968-0896(03)00523-6
M3 - Article
C2 - 14556789
AN - SCOPUS:0141923190
VL - 11
SP - 4743
EP - 4747
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
SN - 0968-0896
IS - 22
ER -