Cochlioquinone A1 (CoA1) was newly isolated from the culture extract of Bipolaris zeicola as a potent anti-angiogenic agent. CoA1 inhibited in vitro angiogenesis of bovine aortic endothelial cells (BAECs) such as bFGF-induced tube formation and invasion at the concentration (1 μg/mL) without cytotoxicity. Notably, CoA1 exhibited more potent inhibition activity for the growth of BAECs than that of normal and cancer cell lines investigated in this study. These results demonstrate that CoA1 is a new anti-angiogenic agent and can be developed as a new therapeutic agent for angiogenesis-related diseases.
Bibliographical noteFunding Information:
This work was supported by grant numbers MG 02-0302-006-1-D-D (to HJK) and MG 02-0101-002-1-0-0 (to CJK) of 21C Frontier Microbial Genomics and Application Project from MOST of Korea and by the Brain Korea 21 project. We are also grateful to Dr. Jo at KNIH for BAECs and Dr. Miyagawa of Kyoto University, Japan for reviewing the chemical structure.
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry