Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola

Hye Jin Jung, Hyang Burm Lee, Chi Hwan Lim, Chang Jin Kim, Ho Jeong Kwon

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Cochlioquinone A1 (CoA1) was newly isolated from the culture extract of Bipolaris zeicola as a potent anti-angiogenic agent. CoA1 inhibited in vitro angiogenesis of bovine aortic endothelial cells (BAECs) such as bFGF-induced tube formation and invasion at the concentration (1 μg/mL) without cytotoxicity. Notably, CoA1 exhibited more potent inhibition activity for the growth of BAECs than that of normal and cancer cell lines investigated in this study. These results demonstrate that CoA1 is a new anti-angiogenic agent and can be developed as a new therapeutic agent for angiogenesis-related diseases.

Original languageEnglish
Pages (from-to)4743-4747
Number of pages5
JournalBioorganic and Medicinal Chemistry
Volume11
Issue number22
DOIs
Publication statusPublished - 2003 Nov 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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