Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola

Hye Jin Jung; Hyang Burm Lee; Chi Hwan Lim; Chang Jin Kim; Ho Jeong Kwon

doi:10.1016/S0968-0896(03)00523-6

Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola

Hye Jin Jung, Hyang Burm Lee, Chi Hwan Lim, Chang Jin Kim, Ho Jeong Kwon

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Cochlioquinone A1 (CoA1) was newly isolated from the culture extract of Bipolaris zeicola as a potent anti-angiogenic agent. CoA1 inhibited in vitro angiogenesis of bovine aortic endothelial cells (BAECs) such as bFGF-induced tube formation and invasion at the concentration (1 μg/mL) without cytotoxicity. Notably, CoA1 exhibited more potent inhibition activity for the growth of BAECs than that of normal and cancer cell lines investigated in this study. These results demonstrate that CoA1 is a new anti-angiogenic agent and can be developed as a new therapeutic agent for angiogenesis-related diseases.

Original language	English
Pages (from-to)	4743-4747
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry
Volume	11
Issue number	22
DOIs	https://doi.org/10.1016/S0968-0896(03)00523-6
Publication status	Published - 2003 Nov 1

Bibliographical note

Funding Information:
This work was supported by grant numbers MG 02-0302-006-1-D-D (to HJK) and MG 02-0101-002-1-0-0 (to CJK) of 21C Frontier Microbial Genomics and Application Project from MOST of Korea and by the Brain Korea 21 project. We are also grateful to Dr. Jo at KNIH for BAECs and Dr. Miyagawa of Kyoto University, Japan for reviewing the chemical structure.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/S0968-0896(03)00523-6

Fingerprint Dive into the research topics of 'Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola'. Together they form a unique fingerprint.

Cite this

@article{ab0c1fb3a54e4d3f946f36366d151ac5,

title = "Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola",

abstract = "Cochlioquinone A1 (CoA1) was newly isolated from the culture extract of Bipolaris zeicola as a potent anti-angiogenic agent. CoA1 inhibited in vitro angiogenesis of bovine aortic endothelial cells (BAECs) such as bFGF-induced tube formation and invasion at the concentration (1 μg/mL) without cytotoxicity. Notably, CoA1 exhibited more potent inhibition activity for the growth of BAECs than that of normal and cancer cell lines investigated in this study. These results demonstrate that CoA1 is a new anti-angiogenic agent and can be developed as a new therapeutic agent for angiogenesis-related diseases.",

author = "Jung, {Hye Jin} and Lee, {Hyang Burm} and Lim, {Chi Hwan} and Kim, {Chang Jin} and Kwon, {Ho Jeong}",

note = "Funding Information: This work was supported by grant numbers MG 02-0302-006-1-D-D (to HJK) and MG 02-0101-002-1-0-0 (to CJK) of 21C Frontier Microbial Genomics and Application Project from MOST of Korea and by the Brain Korea 21 project. We are also grateful to Dr. Jo at KNIH for BAECs and Dr. Miyagawa of Kyoto University, Japan for reviewing the chemical structure.",

year = "2003",

month = nov,

day = "1",

doi = "10.1016/S0968-0896(03)00523-6",

language = "English",

volume = "11",

pages = "4743--4747",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier Limited",

number = "22",

}

TY - JOUR

T1 - Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola

AU - Jung, Hye Jin

AU - Lee, Hyang Burm

AU - Lim, Chi Hwan

AU - Kim, Chang Jin

AU - Kwon, Ho Jeong

N1 - Funding Information: This work was supported by grant numbers MG 02-0302-006-1-D-D (to HJK) and MG 02-0101-002-1-0-0 (to CJK) of 21C Frontier Microbial Genomics and Application Project from MOST of Korea and by the Brain Korea 21 project. We are also grateful to Dr. Jo at KNIH for BAECs and Dr. Miyagawa of Kyoto University, Japan for reviewing the chemical structure.

PY - 2003/11/1

Y1 - 2003/11/1

N2 - Cochlioquinone A1 (CoA1) was newly isolated from the culture extract of Bipolaris zeicola as a potent anti-angiogenic agent. CoA1 inhibited in vitro angiogenesis of bovine aortic endothelial cells (BAECs) such as bFGF-induced tube formation and invasion at the concentration (1 μg/mL) without cytotoxicity. Notably, CoA1 exhibited more potent inhibition activity for the growth of BAECs than that of normal and cancer cell lines investigated in this study. These results demonstrate that CoA1 is a new anti-angiogenic agent and can be developed as a new therapeutic agent for angiogenesis-related diseases.

AB - Cochlioquinone A1 (CoA1) was newly isolated from the culture extract of Bipolaris zeicola as a potent anti-angiogenic agent. CoA1 inhibited in vitro angiogenesis of bovine aortic endothelial cells (BAECs) such as bFGF-induced tube formation and invasion at the concentration (1 μg/mL) without cytotoxicity. Notably, CoA1 exhibited more potent inhibition activity for the growth of BAECs than that of normal and cancer cell lines investigated in this study. These results demonstrate that CoA1 is a new anti-angiogenic agent and can be developed as a new therapeutic agent for angiogenesis-related diseases.

UR - http://www.scopus.com/inward/record.url?scp=0141923190&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141923190&partnerID=8YFLogxK

U2 - 10.1016/S0968-0896(03)00523-6

DO - 10.1016/S0968-0896(03)00523-6

M3 - Article

C2 - 14556789

AN - SCOPUS:0141923190

VL - 11

SP - 4743

EP - 4747

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

SN - 0968-0896

IS - 22

ER -