Coexistence of mupirocin and antiseptic resistance in methicillin-resistant Staphylococcus aureus isolates from Korea

Hyukmin Lee, Hwansub Lim, Il Kown Bae, DongEun Yong, Seokhoon Jeong, Kyungwon Lee, Yunsop Chong

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

In this study, we determined the prevalence of mupirocin and antiseptics resistance in methicillin-resistant Staphylococcus aureus (MRSA) at a secondary- and a tertiary-care hospital in Korea. Mupirocin susceptibility test, ileS gene sequencing, and polymerase chain reaction for mupA, qacA/B, and smr gene were performed with 456 nonduplicated MRSA isolates collected from 2 hospitals in Korea. Genetic relatedness was determined by spa typing and multilocus sequence typing (MLST). The rates of low-level and high-level mupirocin resistance were 7% and 2% in the secondary-care hospital and 17% and 2% in the tertiary-care hospital, respectively. The positive rate of qacA/B and smr gene in mupirocin-resistant MRSA was 65% and 71%, respectively. In spa typing, most mupirocin-resistant MRSA showed genetic relatedness and some of the highly resistant isolates were ST239 and ST5 in MLST analysis. The distribution of low-level and high-level mupirocin resistance and the coexistence of antiseptic resistance in MRSA can result in failure of decolonization in Korea.

Original languageEnglish
Pages (from-to)308-312
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Volume75
Issue number3
DOIs
Publication statusPublished - 2013 Mar 1

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Mupirocin
Local Anti-Infective Agents
Korea
Methicillin-Resistant Staphylococcus aureus
Multilocus Sequence Typing
Tertiary Healthcare
Tertiary Care Centers
Genes
Secondary Care
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

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Coexistence of mupirocin and antiseptic resistance in methicillin-resistant Staphylococcus aureus isolates from Korea. / Lee, Hyukmin; Lim, Hwansub; Bae, Il Kown; Yong, DongEun; Jeong, Seokhoon; Lee, Kyungwon; Chong, Yunsop.

In: Diagnostic Microbiology and Infectious Disease, Vol. 75, No. 3, 01.03.2013, p. 308-312.

Research output: Contribution to journalArticle

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