Cognitive-enhancing activity of loganin isolated from Cornus officinalis in scopolamine-induced amnesic mice

Ki Yong Lee, Sang Hyun Sung, Seung Hyun Kim, Young Pyo Jang, Tae Hwan Oh, Young Choong Kim

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

We examined anti-amnesic activity of the methanolic extract of Cornus officinalis fruits (COT) and a major constituent, loganin using scopolamine-induced (1 mg/kg body weight, s.c.) amnesic mice with both passive avoidance and the Morris water maze tests. Oral treatment of mice with COT (100 mg/kg body weight) and loganin (1 and 2 mg/kg body weight) significantly mitigated scopolamine-induced memory deficits in passive avoidance test. In the Morris water maze test, oral treatment of loganin significantly ameliorated scopolamine-induced memory deficits showing the formation of long-term and/or short-term spatial memory. Moreover, loganin (2 mg/kg body weight) significantly inhibited acetylcholinesterase activity by as much as 45% of control in the mouse hippocampus. These results indicate that loganin may exert antiamnesic activity in in vivo through acetylcholinesterase inhibition.

Original languageEnglish
Pages (from-to)677-683
Number of pages7
JournalArchives of pharmacal research
Volume32
Issue number5
DOIs
Publication statusPublished - 2009 May 1

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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