Cognitive-enhancing activity of loganin isolated from Cornus officinalis in scopolamine-induced amnesic mice

Ki Yong Lee, Sang Hyun Sung, Seung Hyun Kim, Young Pyo Jang, Tae Hwan Oh, Young Choong Kim

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

We examined anti-amnesic activity of the methanolic extract of Cornus officinalis fruits (COT) and a major constituent, loganin using scopolamine-induced (1 mg/kg body weight, s.c.) amnesic mice with both passive avoidance and the Morris water maze tests. Oral treatment of mice with COT (100 mg/kg body weight) and loganin (1 and 2 mg/kg body weight) significantly mitigated scopolamine-induced memory deficits in passive avoidance test. In the Morris water maze test, oral treatment of loganin significantly ameliorated scopolamine-induced memory deficits showing the formation of long-term and/or short-term spatial memory. Moreover, loganin (2 mg/kg body weight) significantly inhibited acetylcholinesterase activity by as much as 45% of control in the mouse hippocampus. These results indicate that loganin may exert antiamnesic activity in in vivo through acetylcholinesterase inhibition.

Original languageEnglish
Pages (from-to)677-683
Number of pages7
JournalArchives of pharmacal research
Volume32
Issue number5
DOIs
Publication statusPublished - 2009 May 1

Fingerprint

Cornus
Scopolamine Hydrobromide
Body Weight
Memory Disorders
Acetylcholinesterase
Fruits
Data storage equipment
Fruit
Water
Short-Term Memory
Hippocampus
loganin

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

Cite this

Lee, Ki Yong ; Sung, Sang Hyun ; Kim, Seung Hyun ; Jang, Young Pyo ; Oh, Tae Hwan ; Kim, Young Choong. / Cognitive-enhancing activity of loganin isolated from Cornus officinalis in scopolamine-induced amnesic mice. In: Archives of pharmacal research. 2009 ; Vol. 32, No. 5. pp. 677-683.
@article{10a617ace5534ae484ed95c13d14708e,
title = "Cognitive-enhancing activity of loganin isolated from Cornus officinalis in scopolamine-induced amnesic mice",
abstract = "We examined anti-amnesic activity of the methanolic extract of Cornus officinalis fruits (COT) and a major constituent, loganin using scopolamine-induced (1 mg/kg body weight, s.c.) amnesic mice with both passive avoidance and the Morris water maze tests. Oral treatment of mice with COT (100 mg/kg body weight) and loganin (1 and 2 mg/kg body weight) significantly mitigated scopolamine-induced memory deficits in passive avoidance test. In the Morris water maze test, oral treatment of loganin significantly ameliorated scopolamine-induced memory deficits showing the formation of long-term and/or short-term spatial memory. Moreover, loganin (2 mg/kg body weight) significantly inhibited acetylcholinesterase activity by as much as 45{\%} of control in the mouse hippocampus. These results indicate that loganin may exert antiamnesic activity in in vivo through acetylcholinesterase inhibition.",
author = "Lee, {Ki Yong} and Sung, {Sang Hyun} and Kim, {Seung Hyun} and Jang, {Young Pyo} and Oh, {Tae Hwan} and Kim, {Young Choong}",
year = "2009",
month = "5",
day = "1",
doi = "10.1007/s12272-009-1505-6",
language = "English",
volume = "32",
pages = "677--683",
journal = "Archives of Pharmacal Research",
issn = "0253-6269",
publisher = "Pharmaceutical Society of Korea",
number = "5",

}

Cognitive-enhancing activity of loganin isolated from Cornus officinalis in scopolamine-induced amnesic mice. / Lee, Ki Yong; Sung, Sang Hyun; Kim, Seung Hyun; Jang, Young Pyo; Oh, Tae Hwan; Kim, Young Choong.

In: Archives of pharmacal research, Vol. 32, No. 5, 01.05.2009, p. 677-683.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cognitive-enhancing activity of loganin isolated from Cornus officinalis in scopolamine-induced amnesic mice

AU - Lee, Ki Yong

AU - Sung, Sang Hyun

AU - Kim, Seung Hyun

AU - Jang, Young Pyo

AU - Oh, Tae Hwan

AU - Kim, Young Choong

PY - 2009/5/1

Y1 - 2009/5/1

N2 - We examined anti-amnesic activity of the methanolic extract of Cornus officinalis fruits (COT) and a major constituent, loganin using scopolamine-induced (1 mg/kg body weight, s.c.) amnesic mice with both passive avoidance and the Morris water maze tests. Oral treatment of mice with COT (100 mg/kg body weight) and loganin (1 and 2 mg/kg body weight) significantly mitigated scopolamine-induced memory deficits in passive avoidance test. In the Morris water maze test, oral treatment of loganin significantly ameliorated scopolamine-induced memory deficits showing the formation of long-term and/or short-term spatial memory. Moreover, loganin (2 mg/kg body weight) significantly inhibited acetylcholinesterase activity by as much as 45% of control in the mouse hippocampus. These results indicate that loganin may exert antiamnesic activity in in vivo through acetylcholinesterase inhibition.

AB - We examined anti-amnesic activity of the methanolic extract of Cornus officinalis fruits (COT) and a major constituent, loganin using scopolamine-induced (1 mg/kg body weight, s.c.) amnesic mice with both passive avoidance and the Morris water maze tests. Oral treatment of mice with COT (100 mg/kg body weight) and loganin (1 and 2 mg/kg body weight) significantly mitigated scopolamine-induced memory deficits in passive avoidance test. In the Morris water maze test, oral treatment of loganin significantly ameliorated scopolamine-induced memory deficits showing the formation of long-term and/or short-term spatial memory. Moreover, loganin (2 mg/kg body weight) significantly inhibited acetylcholinesterase activity by as much as 45% of control in the mouse hippocampus. These results indicate that loganin may exert antiamnesic activity in in vivo through acetylcholinesterase inhibition.

UR - http://www.scopus.com/inward/record.url?scp=67649306759&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649306759&partnerID=8YFLogxK

U2 - 10.1007/s12272-009-1505-6

DO - 10.1007/s12272-009-1505-6

M3 - Article

VL - 32

SP - 677

EP - 683

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

SN - 0253-6269

IS - 5

ER -