Abstract
Purpose The Korean Urban Rural Elderly (KURE) cohort was initiated to study the epidemiologic characteristics, physical performance, laboratory and imaging biomarkers and incidence of age-related diseases in an elderly population with respect to both clinical and social aspects to develop preventive and therapeutic strategies for combatting age-related diseases. Participants A total of 3517 adults aged 65 or older participated in the cohort at baseline from 2012 to 2015, recruited from three urban districts and one rural district in Korea. The second-wave follow-up survey is now being conducted at a 4-year interval from baseline (2016-2019; follow-up rate 71.5%). The data set included detailed information on anthropometric and socioeconomic factors, functional assessments, image scans (plain radiography, dual-energy X-ray absorptiometry and CT), biospecimens (ie, serum, urine and DNA) and social support networks along with the feasibility of linkage to a national claims database. Findings to date Mean age of participants at entry was 71.9±4.6 years and 67% were women. From the KURE participants enrolled in baseline recruitment, several studies were published in the fields of cardiometabolic diseases, musculoskeletal health and the association between social support network and diseases in ageing. Future plans Participants will be observed actively and passively every 4-5 years and the first follow-up will be completed in 2020. The KURE data set has strength in comprehensive physical function assessments, quantifiable imaging data sets using CT and detailed information regarding the social support networks of participants from a large community-based elderly Korean population.
| Original language | English |
|---|---|
| Article number | e031018 |
| Journal | BMJ open |
| Volume | 9 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2019 Oct 1 |
Bibliographical note
Funding Information:The KURE cohort offers valuable resources for investigations of human ageing, including comprehensive assessments of musculoskeletal function, social networks, biospecimens and information from various imaging modalities. We are interested in collaboration for ageing and musculoskeletal research based on the available data within KURE. The survey data set will be made available to researchers after quality control process with permission from the Korean Centers for Disease Control and Prevention. All data sets and bioresources of the KURE cohort are managed by the National Biobank of Korea, Korea National Institute of Health, which holds the right to use or share these resources. Biospecimens of the KURE cohort are not available for sharing at this point and further directions regarding sharing archived biologic materials will be announced by the National Biobank of Korea. Researchers who are interested in the KURE cohort are welcome to contact us (email address: jhkwh@nih.go.kr) for future collaboration. We thank all participants, coordinators, staffs and interviewers of the Korean Urban Rural Elderly cohort. The authors appreciate the meticulous laboratory testing procedures performed by Seoul Clinical Laboratories. NH and K-JK contributed equally. Contributors NH and K-JK contributed to the acquisition of the data and draft of manuscript. HCK contributed to the revision of the manuscript, design/supervision of the study and statistical methodology. YR, J-YC and SJL contributed to the revision of the manuscript and design/supervision of the study. YY contributed to the revision of the manuscript with the specific focus on social network methodology. H-YP contributed to the revision of the manuscript, supervision of the study and acquisition of data. COK is a guarantor, who contributed to the design, manuscript drafting and supervision of the study. All authors read and approved the final manuscript. Funding This work was funded by Research of Korea Centers for Disease Control and Prevention (grant numbers 2013-E63007-01, 2013-E63007-02). Map disclaimer The depiction of boundaries on the map(s) in this article do not imply the expression of any opinion whatsoever on the part of BMJ (or any member of its group) concerning the legal status of any country, territory, jurisdiction or area or of its authorities. The map(s) are provided without any warranty of any kind, either express or implied. Competing interests None declared. Patient consent for publication Not required. Ethics approval This cohort study was approved by the institutional review board of Yonsei University Health System, Severance Hospital (IRB No. 4-2012-0172). Provenance and peer review Not commissioned; externally peer reviewed. Data availability statement The survey data collected in KURE cohort are available on reasonable request. The survey dataset will be made available to researchers after quality control process with permission from the Korean Centers for Disease Control and Prevention. All data sets and bioresources of the KURE cohort are managed by the National Biobank of Korea, Korea National Institute of Health, which holds the right to use or share these resources. Biospecimens of the KURE cohort are not available for sharing at this point and further directions regarding sharing archived biologic materials will be announced by the National Biobank of Korea.
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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
All Science Journal Classification (ASJC) codes
- Medicine(all)