Cold-Adapted Pandemic 2009 H1N1 influenza virus live vaccine elicits cross-reactive immune responses against Seasonal and H5 influenza A viruses

Yo Han Jang, Young Ho Byun, Yoon Jae Lee, Yun Ha Lee, Kwang Hee Lee, Baik Lin Seong

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The rapid transmission of the pandemic 2009 H1N1 influenza virus (pH1N1) among humans has raised the concern of a potential emergence of reassortment between pH1N1 and highly pathogenic influenza strains, especially the avian H5N1 influenza virus. Here, we report that the cold-adapted pH1N1 live attenuated vaccine (CApH1N1) elicits cross-reactive immunity to seasonal and H5 influenza A viruses in the mouse model. Immunization with CApH1N1 induced both systemic and mucosal antibodies with broad reactivity to seasonal and H5 strains, including HAPI H5N1 and the avian H5N2 virus, providing complete protection against heterologous and heterosubtypic lethal challenges. Our results not only accentuate the merit of using live attenuated influenza virus vaccines in view of cross-reactivity but also represent the potential of CApH1N1 live vaccine for mitigating the clinical severity of infections that arise from reassortments between pH1N1 and highly pathogenic H5 subtype viruses.

Original languageEnglish
Pages (from-to)5953-5958
Number of pages6
JournalJournal of Virology
Volume86
Issue number10
DOIs
Publication statusPublished - 2012 May 1

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H1N1 Subtype Influenza A Virus
Attenuated Vaccines
Influenza Vaccines
Influenza A virus
live vaccines
Pandemics
pandemic
Orthomyxoviridae
immune response
H5N2 Subtype Influenza A Virus
H5N1 Subtype Influenza A Virus
Influenza in Birds
Human Influenza
Immunity
Immunization
Vaccines
cross reaction
influenza
Viruses
immunization

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Jang, Yo Han ; Byun, Young Ho ; Lee, Yoon Jae ; Lee, Yun Ha ; Lee, Kwang Hee ; Seong, Baik Lin. / Cold-Adapted Pandemic 2009 H1N1 influenza virus live vaccine elicits cross-reactive immune responses against Seasonal and H5 influenza A viruses. In: Journal of Virology. 2012 ; Vol. 86, No. 10. pp. 5953-5958.
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Cold-Adapted Pandemic 2009 H1N1 influenza virus live vaccine elicits cross-reactive immune responses against Seasonal and H5 influenza A viruses. / Jang, Yo Han; Byun, Young Ho; Lee, Yoon Jae; Lee, Yun Ha; Lee, Kwang Hee; Seong, Baik Lin.

In: Journal of Virology, Vol. 86, No. 10, 01.05.2012, p. 5953-5958.

Research output: Contribution to journalArticle

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