Aims: Because collagen is fundamental to wound healing and skin formation, collagen-containing dressing materials might be beneficial in treating diabetic foot ulcers (DFU), but supporting evidence is needed. Here, we examined the effectiveness and safety of collagen dressing material in DFU treatment. Methods: This prospective, randomized, placebo-controlled, single-center study included patients with type 1 or 2 diabetes and palpable foot pulse who had Wagner grade 1 or 2 ulcers ≥1.0 cm2 with no signs of healing for ≥6 weeks. Patients were treated with foam dressing alone (control group) or with a porcine type I collagen dressing material (collagen group). Complete ulcer healing rate was the primary endpoint, and healing velocity and time to 50% size reduction were secondary endpoints. Results: Thirty patients were included (collagen group: 17, control group: 13). There were no significant differences in demographic factors or baseline DFU characteristics. Compared to the control group, the collagen group presented a higher rate of complete healing [82.4% vs. 38.5%, P = .022], faster healing velocity (P < .05), and shorter median time to 50% size reduction (21 versus 42 days; hazard ratio = 1.94, P < .05). Conclusions: Wound management using collagen materials in DFUs showed faster and complete healing rate.
Bibliographical noteFunding Information:
This study was supported in part (collagen dressing materials) by providing from SK bioland Co. Ltd. (Cheongju, South Korea). This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Author Contributions. K.H.P researched clinical data and conducted data analyses, and wrote the manuscript. J.B.K. J.H.P. and J.C.S. collected clinical data and edited the manuscript. S.H.H and J.W.L. reviewed the manuscript and are the guarantors of this work and, as such, had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. reviewed the manuscript.
This study was supported in part (collagen dressing materials) by providing from SK bioland Co., Ltd. (Cheongju, South Korea).
All Science Journal Classification (ASJC) codes
- Internal Medicine
- Endocrinology, Diabetes and Metabolism