Collagen dressing in the treatment of diabetic foot ulcer: A prospective, randomized, placebo-controlled, single-center study

Kwang Hwan Park, Jae Bum Kwon, Jae Han Park, Ju Cheol Shin, Seung Hwan Han, Jin Woo Lee

Research output: Contribution to journalArticle

Abstract

Aims: Because collagen is fundamental to wound healing and skin formation, collagen-containing dressing materials might be beneficial in treating diabetic foot ulcers (DFU), but supporting evidence is needed. Here, we examined the effectiveness and safety of collagen dressing material in DFU treatment. Methods: This prospective, randomized, placebo-controlled, single-center study included patients with type 1 or 2 diabetes and palpable foot pulse who had Wagner grade 1 or 2 ulcers ≥1.0 cm2 with no signs of healing for ≥6 weeks. Patients were treated with foam dressing alone (control group) or with a porcine type I collagen dressing material (collagen group). Complete ulcer healing rate was the primary endpoint, and healing velocity and time to 50% size reduction were secondary endpoints. Results: Thirty patients were included (collagen group: 17, control group: 13). There were no significant differences in demographic factors or baseline DFU characteristics. Compared to the control group, the collagen group presented a higher rate of complete healing [82.4% vs. 38.5%, P = .022], faster healing velocity (P < .05), and shorter median time to 50% size reduction (21 versus 42 days; hazard ratio = 1.94, P < .05). Conclusions: Wound management using collagen materials in DFUs showed faster and complete healing rate.

Original languageEnglish
Article number107861
JournalDiabetes Research and Clinical Practice
Volume156
DOIs
Publication statusPublished - 2019 Oct

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Diabetic Foot
Bandages
Collagen
Placebos
Control Groups
Therapeutics
Ulcer
Collagen Type I
Type 1 Diabetes Mellitus
Wound Healing
Type 2 Diabetes Mellitus
Foot
Swine
Demography
Safety
Skin
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

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title = "Collagen dressing in the treatment of diabetic foot ulcer: A prospective, randomized, placebo-controlled, single-center study",
abstract = "Aims: Because collagen is fundamental to wound healing and skin formation, collagen-containing dressing materials might be beneficial in treating diabetic foot ulcers (DFU), but supporting evidence is needed. Here, we examined the effectiveness and safety of collagen dressing material in DFU treatment. Methods: This prospective, randomized, placebo-controlled, single-center study included patients with type 1 or 2 diabetes and palpable foot pulse who had Wagner grade 1 or 2 ulcers ≥1.0 cm2 with no signs of healing for ≥6 weeks. Patients were treated with foam dressing alone (control group) or with a porcine type I collagen dressing material (collagen group). Complete ulcer healing rate was the primary endpoint, and healing velocity and time to 50{\%} size reduction were secondary endpoints. Results: Thirty patients were included (collagen group: 17, control group: 13). There were no significant differences in demographic factors or baseline DFU characteristics. Compared to the control group, the collagen group presented a higher rate of complete healing [82.4{\%} vs. 38.5{\%}, P = .022], faster healing velocity (P < .05), and shorter median time to 50{\%} size reduction (21 versus 42 days; hazard ratio = 1.94, P < .05). Conclusions: Wound management using collagen materials in DFUs showed faster and complete healing rate.",
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Collagen dressing in the treatment of diabetic foot ulcer : A prospective, randomized, placebo-controlled, single-center study. / Park, Kwang Hwan; Kwon, Jae Bum; Park, Jae Han; Shin, Ju Cheol; Han, Seung Hwan; Lee, Jin Woo.

In: Diabetes Research and Clinical Practice, Vol. 156, 107861, 10.2019.

Research output: Contribution to journalArticle

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T1 - Collagen dressing in the treatment of diabetic foot ulcer

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AU - Kwon, Jae Bum

AU - Park, Jae Han

AU - Shin, Ju Cheol

AU - Han, Seung Hwan

AU - Lee, Jin Woo

PY - 2019/10

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AB - Aims: Because collagen is fundamental to wound healing and skin formation, collagen-containing dressing materials might be beneficial in treating diabetic foot ulcers (DFU), but supporting evidence is needed. Here, we examined the effectiveness and safety of collagen dressing material in DFU treatment. Methods: This prospective, randomized, placebo-controlled, single-center study included patients with type 1 or 2 diabetes and palpable foot pulse who had Wagner grade 1 or 2 ulcers ≥1.0 cm2 with no signs of healing for ≥6 weeks. Patients were treated with foam dressing alone (control group) or with a porcine type I collagen dressing material (collagen group). Complete ulcer healing rate was the primary endpoint, and healing velocity and time to 50% size reduction were secondary endpoints. Results: Thirty patients were included (collagen group: 17, control group: 13). There were no significant differences in demographic factors or baseline DFU characteristics. Compared to the control group, the collagen group presented a higher rate of complete healing [82.4% vs. 38.5%, P = .022], faster healing velocity (P < .05), and shorter median time to 50% size reduction (21 versus 42 days; hazard ratio = 1.94, P < .05). Conclusions: Wound management using collagen materials in DFUs showed faster and complete healing rate.

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