Collagen XVIII and corneal reinnervation following keratectomy

Tohru Sakimoto, Tae im Kim, David Ellenberg, Naomi Fukai, Sandeep Jain, Dimitri T. Azar, Jin Hong Chang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The significance of collagen XVIII in the regulation of corneal reinnervation remains largely unknown. We used whole-mount immunoconfocal microscopy to localize collagen XVIII to the nerve basement membrane of wild-type (WT) mouse corneas. Transmission electron microscopy showed corneal nerve disorganization in collagen XVIII knockout mice (col18a1-/-). Antibody 2H3-specific neurofilament colocalized with collagens XVIII and IV and laminin-2 in WT mouse corneas, but did not colocalize with collagen IV and laminin-2 in col18a1-/- mouse corneas. Following keratectomy, col18a1-/- mice displayed decreased corneal neurite extension compared to WT mice. Our data indicate that collagen XVIII may play an important role in corneal reinnervation after wounding.

Original languageEnglish
Pages (from-to)3674-3680
Number of pages7
JournalFEBS Letters
Volume582
Issue number25-26
DOIs
Publication statusPublished - 2008 Oct 29

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Sakimoto, T., Kim, T. I., Ellenberg, D., Fukai, N., Jain, S., Azar, D. T., & Chang, J. H. (2008). Collagen XVIII and corneal reinnervation following keratectomy. FEBS Letters, 582(25-26), 3674-3680. https://doi.org/10.1016/j.febslet.2008.09.052