Colon carcinoma in childhood: Review of the literature with four case reports

Gangmi Kim, Seung Hyuk Baik, Kang Young Lee, Hyuk Hur, Byung Soh Min, Chuhl Joo Lyu, Namkyu Kim

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Purpose: Colorectal cancer (CRC) in childhood is extremely rare, and only a few case reports exist. We hereby present four cases of childhood CRC along with a literature review. Methods: A retrospective review of four cases from our institute was conducted, and 15 articles from PubMed describing childhood CRC were reviewed. Results: Case reports: Four patients ranging in age from 11 to 14 years were treated for colon cancer between the years 2000 and 2011. The presenting symptoms varied and included abdominal pain, nausea, vomiting, diarrhea, constipation, and hematochezia, with symptom duration ranging from a few days to 4 months. No patient had a predisposing disease or syndrome. All patients underwent surgical resections, with the most prevalent histology being mucinous adenocarcinoma. Despite radical surgery followed by systemic chemotherapy, the disease progressed in all patients. Literature review: A total of 239 cases were reviewed. The youngest patient was 6 years old. The most frequent predisposing conditions were hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis. Most of the patients presented advanced stage, with the most common histopathologic diagnosis being mucinous adenocarcinoma, followed by poorly differentiated adenocarcinoma and signet ring cell carcinoma. Even though most of the patients underwent aggressive treatment, the overall prognosis was poor. Conclusions: Childhood CRC has an aggressive pathology and distinct genetic features, which result in an advanced stage at diagnosis and consequently a poor prognosis. Although the incidence is very low, every physician should be aware of CRC as a possible childhood diagnosis.

Original languageEnglish
Pages (from-to)157-164
Number of pages8
JournalInternational Journal of Colorectal Disease
Volume28
Issue number2
DOIs
Publication statusPublished - 2013 Feb 1

Fingerprint

Colon
Carcinoma
Colorectal Neoplasms
Mucinous Adenocarcinoma
Signet Ring Cell Carcinoma
Hereditary Nonpolyposis Colorectal Neoplasms
Adenomatous Polyposis Coli
Gastrointestinal Hemorrhage
Constipation
PubMed
Colonic Neoplasms
Nausea
Abdominal Pain
Vomiting
Diarrhea
Histology
Adenocarcinoma
Pathology
Physicians
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Kim, Gangmi ; Baik, Seung Hyuk ; Lee, Kang Young ; Hur, Hyuk ; Min, Byung Soh ; Lyu, Chuhl Joo ; Kim, Namkyu. / Colon carcinoma in childhood : Review of the literature with four case reports. In: International Journal of Colorectal Disease. 2013 ; Vol. 28, No. 2. pp. 157-164.
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abstract = "Purpose: Colorectal cancer (CRC) in childhood is extremely rare, and only a few case reports exist. We hereby present four cases of childhood CRC along with a literature review. Methods: A retrospective review of four cases from our institute was conducted, and 15 articles from PubMed describing childhood CRC were reviewed. Results: Case reports: Four patients ranging in age from 11 to 14 years were treated for colon cancer between the years 2000 and 2011. The presenting symptoms varied and included abdominal pain, nausea, vomiting, diarrhea, constipation, and hematochezia, with symptom duration ranging from a few days to 4 months. No patient had a predisposing disease or syndrome. All patients underwent surgical resections, with the most prevalent histology being mucinous adenocarcinoma. Despite radical surgery followed by systemic chemotherapy, the disease progressed in all patients. Literature review: A total of 239 cases were reviewed. The youngest patient was 6 years old. The most frequent predisposing conditions were hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis. Most of the patients presented advanced stage, with the most common histopathologic diagnosis being mucinous adenocarcinoma, followed by poorly differentiated adenocarcinoma and signet ring cell carcinoma. Even though most of the patients underwent aggressive treatment, the overall prognosis was poor. Conclusions: Childhood CRC has an aggressive pathology and distinct genetic features, which result in an advanced stage at diagnosis and consequently a poor prognosis. Although the incidence is very low, every physician should be aware of CRC as a possible childhood diagnosis.",
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Colon carcinoma in childhood : Review of the literature with four case reports. / Kim, Gangmi; Baik, Seung Hyuk; Lee, Kang Young; Hur, Hyuk; Min, Byung Soh; Lyu, Chuhl Joo; Kim, Namkyu.

In: International Journal of Colorectal Disease, Vol. 28, No. 2, 01.02.2013, p. 157-164.

Research output: Contribution to journalReview article

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T2 - Review of the literature with four case reports

AU - Kim, Gangmi

AU - Baik, Seung Hyuk

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N2 - Purpose: Colorectal cancer (CRC) in childhood is extremely rare, and only a few case reports exist. We hereby present four cases of childhood CRC along with a literature review. Methods: A retrospective review of four cases from our institute was conducted, and 15 articles from PubMed describing childhood CRC were reviewed. Results: Case reports: Four patients ranging in age from 11 to 14 years were treated for colon cancer between the years 2000 and 2011. The presenting symptoms varied and included abdominal pain, nausea, vomiting, diarrhea, constipation, and hematochezia, with symptom duration ranging from a few days to 4 months. No patient had a predisposing disease or syndrome. All patients underwent surgical resections, with the most prevalent histology being mucinous adenocarcinoma. Despite radical surgery followed by systemic chemotherapy, the disease progressed in all patients. Literature review: A total of 239 cases were reviewed. The youngest patient was 6 years old. The most frequent predisposing conditions were hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis. Most of the patients presented advanced stage, with the most common histopathologic diagnosis being mucinous adenocarcinoma, followed by poorly differentiated adenocarcinoma and signet ring cell carcinoma. Even though most of the patients underwent aggressive treatment, the overall prognosis was poor. Conclusions: Childhood CRC has an aggressive pathology and distinct genetic features, which result in an advanced stage at diagnosis and consequently a poor prognosis. Although the incidence is very low, every physician should be aware of CRC as a possible childhood diagnosis.

AB - Purpose: Colorectal cancer (CRC) in childhood is extremely rare, and only a few case reports exist. We hereby present four cases of childhood CRC along with a literature review. Methods: A retrospective review of four cases from our institute was conducted, and 15 articles from PubMed describing childhood CRC were reviewed. Results: Case reports: Four patients ranging in age from 11 to 14 years were treated for colon cancer between the years 2000 and 2011. The presenting symptoms varied and included abdominal pain, nausea, vomiting, diarrhea, constipation, and hematochezia, with symptom duration ranging from a few days to 4 months. No patient had a predisposing disease or syndrome. All patients underwent surgical resections, with the most prevalent histology being mucinous adenocarcinoma. Despite radical surgery followed by systemic chemotherapy, the disease progressed in all patients. Literature review: A total of 239 cases were reviewed. The youngest patient was 6 years old. The most frequent predisposing conditions were hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis. Most of the patients presented advanced stage, with the most common histopathologic diagnosis being mucinous adenocarcinoma, followed by poorly differentiated adenocarcinoma and signet ring cell carcinoma. Even though most of the patients underwent aggressive treatment, the overall prognosis was poor. Conclusions: Childhood CRC has an aggressive pathology and distinct genetic features, which result in an advanced stage at diagnosis and consequently a poor prognosis. Although the incidence is very low, every physician should be aware of CRC as a possible childhood diagnosis.

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