Color capable sub-pixel resolving optofluidic microscope and its application to blood cell imaging for malaria diagnosis

Seung Ah Lee, Ricardo Leitao, Guoan Zheng, Samuel Yang, Ana Rodriguez, Changhuei Yang

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Miniaturization of imaging systems can significantly benefit clinical diagnosis in challenging environments, where access to physicians and good equipment can be limited. Sub-pixel resolving optofluidic microscope (SROFM) offers high-resolution imaging in the form of an on-chip device, with the combination of microfluidics and inexpensive CMOS image sensors. In this work, we report on the implementation of color SROFM prototypes with a demonstrated optical resolution of 0.66 μm at their highest acuity. We applied the prototypes to perform color imaging of red blood cells (RBCs) infected with Plasmodium falciparum, a particularly harmful type of malaria parasites and one of the major causes of death in the developing world.

Original languageEnglish
Article numbere26127
JournalPloS one
Volume6
Issue number10
DOIs
Publication statusPublished - 2011 Oct 11

Fingerprint

blood cells
microscopes
malaria
Malaria
Blood Cells
Microscopes
Blood
Color
Pixels
Cells
image analysis
Miniaturization
Imaging techniques
prototypes
Equipment and Supplies
Microfluidics
color
Plasmodium falciparum
Image sensors
Imaging systems

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Lee, Seung Ah ; Leitao, Ricardo ; Zheng, Guoan ; Yang, Samuel ; Rodriguez, Ana ; Yang, Changhuei. / Color capable sub-pixel resolving optofluidic microscope and its application to blood cell imaging for malaria diagnosis. In: PloS one. 2011 ; Vol. 6, No. 10.
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Color capable sub-pixel resolving optofluidic microscope and its application to blood cell imaging for malaria diagnosis. / Lee, Seung Ah; Leitao, Ricardo; Zheng, Guoan; Yang, Samuel; Rodriguez, Ana; Yang, Changhuei.

In: PloS one, Vol. 6, No. 10, e26127, 11.10.2011.

Research output: Contribution to journalArticle

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