Color capable sub-pixel resolving optofluidic microscope and its application to blood cell imaging for malaria diagnosis

Seung Ah Lee, Ricardo Leitao, Guoan Zheng, Samuel Yang, Ana Rodriguez, Changhuei Yang

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Miniaturization of imaging systems can significantly benefit clinical diagnosis in challenging environments, where access to physicians and good equipment can be limited. Sub-pixel resolving optofluidic microscope (SROFM) offers high-resolution imaging in the form of an on-chip device, with the combination of microfluidics and inexpensive CMOS image sensors. In this work, we report on the implementation of color SROFM prototypes with a demonstrated optical resolution of 0.66 μm at their highest acuity. We applied the prototypes to perform color imaging of red blood cells (RBCs) infected with Plasmodium falciparum, a particularly harmful type of malaria parasites and one of the major causes of death in the developing world.

Original languageEnglish
Article numbere26127
JournalPloS one
Issue number10
Publication statusPublished - 2011 Oct 11


All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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