Color sub-pixel resolving optofluidic microscope and its application to blood cell imaging for malaria diagnosis

Seung Ah Lee, Ricardo Leitao, Guoan Zheng, Samuel Yang, Ana Rodriguez, Changhuei Yang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report on the implementation of color sub-pixel resolving optofluidic microscope (SROFM), a high resolution (HR) on-chip imaging system for diagnostic applications in rural regions. With the combination of microfluidics and inexpensive complementary metal oxide semiconductor (CMOS) image sensors, we demonstrate optical resolution of 0.66 μm at the highest acuity. We applied the prototypes to perform color imaging of red blood cells (RBCs) infected with Plasmodium fal-ciparum (P. falciparum), a particularly harmful type of malaria parasites and one of the major causes of death in the developing world.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages1947-1949
Number of pages3
Volume3
Publication statusPublished - 2011 Dec 1
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: 2011 Oct 22011 Oct 6

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period11/10/211/10/6

Fingerprint

Microscopes
Blood
Pixels
Cells
Color
Imaging techniques
Microfluidics
Image sensors
Imaging systems
Metals
Parasites
Oxide semiconductors

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Cite this

Lee, S. A., Leitao, R., Zheng, G., Yang, S., Rodriguez, A., & Yang, C. (2011). Color sub-pixel resolving optofluidic microscope and its application to blood cell imaging for malaria diagnosis. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (Vol. 3, pp. 1947-1949)
Lee, Seung Ah ; Leitao, Ricardo ; Zheng, Guoan ; Yang, Samuel ; Rodriguez, Ana ; Yang, Changhuei. / Color sub-pixel resolving optofluidic microscope and its application to blood cell imaging for malaria diagnosis. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 3 2011. pp. 1947-1949
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abstract = "We report on the implementation of color sub-pixel resolving optofluidic microscope (SROFM), a high resolution (HR) on-chip imaging system for diagnostic applications in rural regions. With the combination of microfluidics and inexpensive complementary metal oxide semiconductor (CMOS) image sensors, we demonstrate optical resolution of 0.66 μm at the highest acuity. We applied the prototypes to perform color imaging of red blood cells (RBCs) infected with Plasmodium fal-ciparum (P. falciparum), a particularly harmful type of malaria parasites and one of the major causes of death in the developing world.",
author = "Lee, {Seung Ah} and Ricardo Leitao and Guoan Zheng and Samuel Yang and Ana Rodriguez and Changhuei Yang",
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Lee, SA, Leitao, R, Zheng, G, Yang, S, Rodriguez, A & Yang, C 2011, Color sub-pixel resolving optofluidic microscope and its application to blood cell imaging for malaria diagnosis. in 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. vol. 3, pp. 1947-1949, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, Seattle, WA, United States, 11/10/2.

Color sub-pixel resolving optofluidic microscope and its application to blood cell imaging for malaria diagnosis. / Lee, Seung Ah; Leitao, Ricardo; Zheng, Guoan; Yang, Samuel; Rodriguez, Ana; Yang, Changhuei.

15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 3 2011. p. 1947-1949.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Lee SA, Leitao R, Zheng G, Yang S, Rodriguez A, Yang C. Color sub-pixel resolving optofluidic microscope and its application to blood cell imaging for malaria diagnosis. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 3. 2011. p. 1947-1949