Combination of preS deletions and A1762T/G1764A mutations in HBV subgenotype C2 increases the risk of developing HCC

Myoung Ha Lee, Do Young Kim, Ja Kyung Kim, Hye Young Chang, Se Hun Kang, Han Jak Ryu, Hye Lim Ju, Seung Up Kim, Jung Min Lee, Jun Yong Park, Kwang Hyub Han, Chae Yoon Chon, Sang Hoon Ahn

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9 Citations (Scopus)

Abstract

Background: The interactions among hepatitis B virus (HBV) mutations in developing hepatocellular carcinoma (HCC) remain unclear and thus we investigated the risk of HCC related with single or multiple HBV mutations in Korean patients infected with HBV subgenotype C2. Methods: From January 2003 to December 2008, HBV isolates from 135 patients with HCC were compared with those from 135 patients without HCC, matching for age, gender, and HBeAg status. The prevalence of preS deletions and G1896A and A1762T/G1764A mutations was evaluated. Results: The frequency of preS deletions significantly differed between the non-HCC and HCC groups, with 6 (4.4%) versus 25 (18.5%) patients, respectively (p < 0.001). Additionally, the frequency of A1762T/G1764A mutations was higher in the HCC than the non-HCC group [82 (60.7%) versus 30 (22.2%), p < 0.001]. For combined mutations, the odds ratio (OR) was highest in patients with both preS deletions and the A1762T/G1764A mutation, with 1 (0.7%) versus 11 (8.1%) patients (p = 0.005; OR 11.887). Conclusions: HCC was associated with preS deletions and A1762T/G1764A mutations, and the combination of both mutations had a stronger association with HCC in Korean patients infected with HBV subgenotype C2.

Original languageEnglish
Pages (from-to)296-302
Number of pages7
JournalIntervirology
Volume55
Issue number4
DOIs
Publication statusPublished - 2012 Apr 1

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Hepatitis B virus
Hepatocellular Carcinoma
Mutation
Odds Ratio
Carcinoma
Hepatitis B e Antigens

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cite this

Lee, Myoung Ha ; Kim, Do Young ; Kim, Ja Kyung ; Chang, Hye Young ; Kang, Se Hun ; Ryu, Han Jak ; Ju, Hye Lim ; Kim, Seung Up ; Lee, Jung Min ; Park, Jun Yong ; Han, Kwang Hyub ; Chon, Chae Yoon ; Ahn, Sang Hoon. / Combination of preS deletions and A1762T/G1764A mutations in HBV subgenotype C2 increases the risk of developing HCC. In: Intervirology. 2012 ; Vol. 55, No. 4. pp. 296-302.
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title = "Combination of preS deletions and A1762T/G1764A mutations in HBV subgenotype C2 increases the risk of developing HCC",
abstract = "Background: The interactions among hepatitis B virus (HBV) mutations in developing hepatocellular carcinoma (HCC) remain unclear and thus we investigated the risk of HCC related with single or multiple HBV mutations in Korean patients infected with HBV subgenotype C2. Methods: From January 2003 to December 2008, HBV isolates from 135 patients with HCC were compared with those from 135 patients without HCC, matching for age, gender, and HBeAg status. The prevalence of preS deletions and G1896A and A1762T/G1764A mutations was evaluated. Results: The frequency of preS deletions significantly differed between the non-HCC and HCC groups, with 6 (4.4{\%}) versus 25 (18.5{\%}) patients, respectively (p < 0.001). Additionally, the frequency of A1762T/G1764A mutations was higher in the HCC than the non-HCC group [82 (60.7{\%}) versus 30 (22.2{\%}), p < 0.001]. For combined mutations, the odds ratio (OR) was highest in patients with both preS deletions and the A1762T/G1764A mutation, with 1 (0.7{\%}) versus 11 (8.1{\%}) patients (p = 0.005; OR 11.887). Conclusions: HCC was associated with preS deletions and A1762T/G1764A mutations, and the combination of both mutations had a stronger association with HCC in Korean patients infected with HBV subgenotype C2.",
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Combination of preS deletions and A1762T/G1764A mutations in HBV subgenotype C2 increases the risk of developing HCC. / Lee, Myoung Ha; Kim, Do Young; Kim, Ja Kyung; Chang, Hye Young; Kang, Se Hun; Ryu, Han Jak; Ju, Hye Lim; Kim, Seung Up; Lee, Jung Min; Park, Jun Yong; Han, Kwang Hyub; Chon, Chae Yoon; Ahn, Sang Hoon.

In: Intervirology, Vol. 55, No. 4, 01.04.2012, p. 296-302.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Combination of preS deletions and A1762T/G1764A mutations in HBV subgenotype C2 increases the risk of developing HCC

AU - Lee, Myoung Ha

AU - Kim, Do Young

AU - Kim, Ja Kyung

AU - Chang, Hye Young

AU - Kang, Se Hun

AU - Ryu, Han Jak

AU - Ju, Hye Lim

AU - Kim, Seung Up

AU - Lee, Jung Min

AU - Park, Jun Yong

AU - Han, Kwang Hyub

AU - Chon, Chae Yoon

AU - Ahn, Sang Hoon

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Background: The interactions among hepatitis B virus (HBV) mutations in developing hepatocellular carcinoma (HCC) remain unclear and thus we investigated the risk of HCC related with single or multiple HBV mutations in Korean patients infected with HBV subgenotype C2. Methods: From January 2003 to December 2008, HBV isolates from 135 patients with HCC were compared with those from 135 patients without HCC, matching for age, gender, and HBeAg status. The prevalence of preS deletions and G1896A and A1762T/G1764A mutations was evaluated. Results: The frequency of preS deletions significantly differed between the non-HCC and HCC groups, with 6 (4.4%) versus 25 (18.5%) patients, respectively (p < 0.001). Additionally, the frequency of A1762T/G1764A mutations was higher in the HCC than the non-HCC group [82 (60.7%) versus 30 (22.2%), p < 0.001]. For combined mutations, the odds ratio (OR) was highest in patients with both preS deletions and the A1762T/G1764A mutation, with 1 (0.7%) versus 11 (8.1%) patients (p = 0.005; OR 11.887). Conclusions: HCC was associated with preS deletions and A1762T/G1764A mutations, and the combination of both mutations had a stronger association with HCC in Korean patients infected with HBV subgenotype C2.

AB - Background: The interactions among hepatitis B virus (HBV) mutations in developing hepatocellular carcinoma (HCC) remain unclear and thus we investigated the risk of HCC related with single or multiple HBV mutations in Korean patients infected with HBV subgenotype C2. Methods: From January 2003 to December 2008, HBV isolates from 135 patients with HCC were compared with those from 135 patients without HCC, matching for age, gender, and HBeAg status. The prevalence of preS deletions and G1896A and A1762T/G1764A mutations was evaluated. Results: The frequency of preS deletions significantly differed between the non-HCC and HCC groups, with 6 (4.4%) versus 25 (18.5%) patients, respectively (p < 0.001). Additionally, the frequency of A1762T/G1764A mutations was higher in the HCC than the non-HCC group [82 (60.7%) versus 30 (22.2%), p < 0.001]. For combined mutations, the odds ratio (OR) was highest in patients with both preS deletions and the A1762T/G1764A mutation, with 1 (0.7%) versus 11 (8.1%) patients (p = 0.005; OR 11.887). Conclusions: HCC was associated with preS deletions and A1762T/G1764A mutations, and the combination of both mutations had a stronger association with HCC in Korean patients infected with HBV subgenotype C2.

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