Combinatorial application of dissolving microneedle patch and cream for improvement of skin wrinkles, dermal density, elasticity, and hydration

Geonwoo Kang, Suyong Kim, Huisuk Yang, Mingyu Jang, Liching Chiang, Ji Hwoon Baek, Ja Hyun Ryu, Go Woon Choi, Hyungil Jung

Research output: Contribution to journalArticle

Abstract

Background: Dissolving microneedles (DMNs), microscale needles with a biodegradable polymer matrix, have been widely investigated for transdermal drug delivery. However, the restricted drug loading space of DMNs limited the delivery of the desired quantity of active compounds. In this study, we developed novel combinatorial therapies involving sequential application of adenosine-loaded DMN (Ad-DMN) patches and a topical adenosine-loaded cream (Ad-cream). The application of DMNs created skin channels, which delivered encapsulated drugs from both the DMNs and cream. The use of combinatorial therapies can maximize drug delivery. Methods: To compare the efficacy of combinatorial therapies and Ad-cream application, a double-blind clinical test was conducted over 10 weeks on 21 females with wrinkles around their eyes, and the skin parameters such as wrinkles, dermal density, elasticity, and hydration were analyzed. The skin irritation test was assessed by expert interviewers to elucidate undesirable side effects. Results: The combinatorial therapies showed statistically significant efficacy for the improvement of average depth of wrinkles, dermal density, elasticity, and hydration after an 8-week application (P < 0.001). Adverse effects on the skin were not observed in any subject during the test period. Conclusion: The efficacy and safety results showed that the combinatorial therapies were a safe and outstanding innovation for the optimization of transdermal therapy.

Original languageEnglish
Pages (from-to)1083-1091
Number of pages9
JournalJournal of Cosmetic Dermatology
Volume18
Issue number4
DOIs
Publication statusPublished - 2019 Aug

Fingerprint

Skin Cream
Elasticity
Skin
Adenosine
Pharmaceutical Preparations
Therapeutics
Skin Tests
Needles
Polymers
Interviews
Safety

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Kang, Geonwoo ; Kim, Suyong ; Yang, Huisuk ; Jang, Mingyu ; Chiang, Liching ; Baek, Ji Hwoon ; Ryu, Ja Hyun ; Choi, Go Woon ; Jung, Hyungil. / Combinatorial application of dissolving microneedle patch and cream for improvement of skin wrinkles, dermal density, elasticity, and hydration. In: Journal of Cosmetic Dermatology. 2019 ; Vol. 18, No. 4. pp. 1083-1091.
@article{51c6baf5d4864af9aeb3502afd1f087e,
title = "Combinatorial application of dissolving microneedle patch and cream for improvement of skin wrinkles, dermal density, elasticity, and hydration",
abstract = "Background: Dissolving microneedles (DMNs), microscale needles with a biodegradable polymer matrix, have been widely investigated for transdermal drug delivery. However, the restricted drug loading space of DMNs limited the delivery of the desired quantity of active compounds. In this study, we developed novel combinatorial therapies involving sequential application of adenosine-loaded DMN (Ad-DMN) patches and a topical adenosine-loaded cream (Ad-cream). The application of DMNs created skin channels, which delivered encapsulated drugs from both the DMNs and cream. The use of combinatorial therapies can maximize drug delivery. Methods: To compare the efficacy of combinatorial therapies and Ad-cream application, a double-blind clinical test was conducted over 10 weeks on 21 females with wrinkles around their eyes, and the skin parameters such as wrinkles, dermal density, elasticity, and hydration were analyzed. The skin irritation test was assessed by expert interviewers to elucidate undesirable side effects. Results: The combinatorial therapies showed statistically significant efficacy for the improvement of average depth of wrinkles, dermal density, elasticity, and hydration after an 8-week application (P < 0.001). Adverse effects on the skin were not observed in any subject during the test period. Conclusion: The efficacy and safety results showed that the combinatorial therapies were a safe and outstanding innovation for the optimization of transdermal therapy.",
author = "Geonwoo Kang and Suyong Kim and Huisuk Yang and Mingyu Jang and Liching Chiang and Baek, {Ji Hwoon} and Ryu, {Ja Hyun} and Choi, {Go Woon} and Hyungil Jung",
year = "2019",
month = "8",
doi = "10.1111/jocd.12807",
language = "English",
volume = "18",
pages = "1083--1091",
journal = "Journal of Cosmetic Dermatology",
issn = "1473-2130",
publisher = "Wiley-Blackwell",
number = "4",

}

Combinatorial application of dissolving microneedle patch and cream for improvement of skin wrinkles, dermal density, elasticity, and hydration. / Kang, Geonwoo; Kim, Suyong; Yang, Huisuk; Jang, Mingyu; Chiang, Liching; Baek, Ji Hwoon; Ryu, Ja Hyun; Choi, Go Woon; Jung, Hyungil.

In: Journal of Cosmetic Dermatology, Vol. 18, No. 4, 08.2019, p. 1083-1091.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Combinatorial application of dissolving microneedle patch and cream for improvement of skin wrinkles, dermal density, elasticity, and hydration

AU - Kang, Geonwoo

AU - Kim, Suyong

AU - Yang, Huisuk

AU - Jang, Mingyu

AU - Chiang, Liching

AU - Baek, Ji Hwoon

AU - Ryu, Ja Hyun

AU - Choi, Go Woon

AU - Jung, Hyungil

PY - 2019/8

Y1 - 2019/8

N2 - Background: Dissolving microneedles (DMNs), microscale needles with a biodegradable polymer matrix, have been widely investigated for transdermal drug delivery. However, the restricted drug loading space of DMNs limited the delivery of the desired quantity of active compounds. In this study, we developed novel combinatorial therapies involving sequential application of adenosine-loaded DMN (Ad-DMN) patches and a topical adenosine-loaded cream (Ad-cream). The application of DMNs created skin channels, which delivered encapsulated drugs from both the DMNs and cream. The use of combinatorial therapies can maximize drug delivery. Methods: To compare the efficacy of combinatorial therapies and Ad-cream application, a double-blind clinical test was conducted over 10 weeks on 21 females with wrinkles around their eyes, and the skin parameters such as wrinkles, dermal density, elasticity, and hydration were analyzed. The skin irritation test was assessed by expert interviewers to elucidate undesirable side effects. Results: The combinatorial therapies showed statistically significant efficacy for the improvement of average depth of wrinkles, dermal density, elasticity, and hydration after an 8-week application (P < 0.001). Adverse effects on the skin were not observed in any subject during the test period. Conclusion: The efficacy and safety results showed that the combinatorial therapies were a safe and outstanding innovation for the optimization of transdermal therapy.

AB - Background: Dissolving microneedles (DMNs), microscale needles with a biodegradable polymer matrix, have been widely investigated for transdermal drug delivery. However, the restricted drug loading space of DMNs limited the delivery of the desired quantity of active compounds. In this study, we developed novel combinatorial therapies involving sequential application of adenosine-loaded DMN (Ad-DMN) patches and a topical adenosine-loaded cream (Ad-cream). The application of DMNs created skin channels, which delivered encapsulated drugs from both the DMNs and cream. The use of combinatorial therapies can maximize drug delivery. Methods: To compare the efficacy of combinatorial therapies and Ad-cream application, a double-blind clinical test was conducted over 10 weeks on 21 females with wrinkles around their eyes, and the skin parameters such as wrinkles, dermal density, elasticity, and hydration were analyzed. The skin irritation test was assessed by expert interviewers to elucidate undesirable side effects. Results: The combinatorial therapies showed statistically significant efficacy for the improvement of average depth of wrinkles, dermal density, elasticity, and hydration after an 8-week application (P < 0.001). Adverse effects on the skin were not observed in any subject during the test period. Conclusion: The efficacy and safety results showed that the combinatorial therapies were a safe and outstanding innovation for the optimization of transdermal therapy.

UR - http://www.scopus.com/inward/record.url?scp=85055720911&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055720911&partnerID=8YFLogxK

U2 - 10.1111/jocd.12807

DO - 10.1111/jocd.12807

M3 - Article

C2 - 30375189

AN - SCOPUS:85055720911

VL - 18

SP - 1083

EP - 1091

JO - Journal of Cosmetic Dermatology

JF - Journal of Cosmetic Dermatology

SN - 1473-2130

IS - 4

ER -