Combined algorithm using a poor increase in inferior P-wave amplitude during sympathetic stimulation and sinus node recovery time for the diagnosis of sick sinus syndrome

Jin Kyu Park, Junbeom Park, Jae Sun Uhm, Hui Nam Pak, Moon Hyoung Lee, Boyoung Joung

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Abstract

Background: This study sought to evaluate whether a poor increase in inferior P-wave amplitude during sympathetic stimulation might be a helpful diagnostic tool for sick sinus syndrome (SSS). Methods and Results: Three-dimensional electroanatomic mapping of the right atrium, inferior P-wave amplitude and conventional corrected sinus node recovery time (CSNRT) were compared in 112 consecutive atrial fibrillation (AF) patients with (n=21) and without SSS (n=91). The significant cranial shift of earliest activation site (EAS) (the distance from the superior vena cava to the EAS: 11.1 vs. 5.9 mm, P<0.001) and the increases of inferior P-wave amplitudes during isoproterenol infusion (all P<0.001) were observed in patients without SSS. However, cranial shift of EAS (16.5 vs. 14.2 mm, P=0.375) and P-wave amplitude increases were not observed in those with SSS. Although CSNRT >550 ms showed a sensitivity of 50% and specificity of 84% for diagnosing SSS, poor increases of P-waves amplitude in lead aVF (<0.1 mV) during isoproterenol infusion showed an improved sensitivity of 71% and specificity of 89%. Finally, the combined algorithm using CSNRT >550 ms and poor increase of P-waves amplitude in lead aVF showed more improved diagnostic accuracy (sensitivity 89%, specificity 75%). Conclusions: A combined algorithm using inferior P-wave amplitude showed improved performance for the diagnosis of SSS compared with CSNRT >550 ms alone.

Original languageEnglish
Pages (from-to)2148-2156
Number of pages9
JournalCirculation Journal
Volume79
Issue number10
DOIs
Publication statusPublished - 2015 Sep 25

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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