Combined effect of initial and longitudinal increases in γ-glutamyltransferase on incident metabolic syndrome: ARIRANG study

Dhananjay Yadav, Mi Young Lee, Jang Young Kim, Hoon Ryu, Ji Hye Huh, Keum Seok Bae, Song Vogue Ahn, Choon Hee Chung, Jong Taek Park, Sang Baek Koh

Research output: Contribution to journalArticle

Abstract

Purpose: Although γ-glutamyltransferase (GGT) is well known to be associated with metabolic syndrome (MS), prospective data on baseline and longitudinal changes in GGT levels and incident cases of MS are limited. We aimed to examine prospective associations between changes in GGT levels over time, as well as at baseline, and incident MS in Korean adults. Materials and Methods: A total of 2579 Korean adults free of MS were followed up for 2.6 years. Data were collected from 2005- 2008 (baseline) and from 2008-2011 (follow-up). Serum GGT levels were determined by enzymatic methods. Results: During follow-up, 558 participants (21.6%) developed MS. A gradual increase in the incidence of MS was observed across GGT quartiles. After adjustment for confounding factors, the odds ratio and 95% confidence interval (CI) for new onset MS, comparing the highest to the lowest quartiles of baseline GGT, was 2.07 (95% CI: 1.52-2.80). The odds ratio for the highest GGT changes (>4 IU/L increase) in comparison to the lowest GGT changes (<-5 IU/L decrease) was 1.75 (95% CI: 1.32-2.33). Among participants with baseline GGT concentrations <the median, the odds ratio for incident MS, comparing participants with the highest GGT changes with the lowest GGT changes, was 1.52 (95% CI: 1.01-2.31). Among participants with baseline GGT concentration ≥the median, the corresponding odds ratio was 2.75 (95% CI: 1.84-4.10). Conclusion: High initial GGT concentration and increases in GGT concentration over time should be considered independent predictors of and to have a combined effect on incident MS.

Original languageEnglish
Pages (from-to)763-769
Number of pages7
JournalYonsei medical journal
Volume58
Issue number4
DOIs
Publication statusPublished - 2017 Jul

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Confidence Intervals
Odds Ratio
Incidence
Serum

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{280c0e0b44324bffbf15304d0061c99c,
title = "Combined effect of initial and longitudinal increases in γ-glutamyltransferase on incident metabolic syndrome: ARIRANG study",
abstract = "Purpose: Although γ-glutamyltransferase (GGT) is well known to be associated with metabolic syndrome (MS), prospective data on baseline and longitudinal changes in GGT levels and incident cases of MS are limited. We aimed to examine prospective associations between changes in GGT levels over time, as well as at baseline, and incident MS in Korean adults. Materials and Methods: A total of 2579 Korean adults free of MS were followed up for 2.6 years. Data were collected from 2005- 2008 (baseline) and from 2008-2011 (follow-up). Serum GGT levels were determined by enzymatic methods. Results: During follow-up, 558 participants (21.6{\%}) developed MS. A gradual increase in the incidence of MS was observed across GGT quartiles. After adjustment for confounding factors, the odds ratio and 95{\%} confidence interval (CI) for new onset MS, comparing the highest to the lowest quartiles of baseline GGT, was 2.07 (95{\%} CI: 1.52-2.80). The odds ratio for the highest GGT changes (>4 IU/L increase) in comparison to the lowest GGT changes (<-5 IU/L decrease) was 1.75 (95{\%} CI: 1.32-2.33). Among participants with baseline GGT concentrations",
author = "Dhananjay Yadav and Lee, {Mi Young} and Kim, {Jang Young} and Hoon Ryu and Huh, {Ji Hye} and Bae, {Keum Seok} and Ahn, {Song Vogue} and Chung, {Choon Hee} and Park, {Jong Taek} and Koh, {Sang Baek}",
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Combined effect of initial and longitudinal increases in γ-glutamyltransferase on incident metabolic syndrome : ARIRANG study. / Yadav, Dhananjay; Lee, Mi Young; Kim, Jang Young; Ryu, Hoon; Huh, Ji Hye; Bae, Keum Seok; Ahn, Song Vogue; Chung, Choon Hee; Park, Jong Taek; Koh, Sang Baek.

In: Yonsei medical journal, Vol. 58, No. 4, 07.2017, p. 763-769.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Combined effect of initial and longitudinal increases in γ-glutamyltransferase on incident metabolic syndrome

T2 - ARIRANG study

AU - Yadav, Dhananjay

AU - Lee, Mi Young

AU - Kim, Jang Young

AU - Ryu, Hoon

AU - Huh, Ji Hye

AU - Bae, Keum Seok

AU - Ahn, Song Vogue

AU - Chung, Choon Hee

AU - Park, Jong Taek

AU - Koh, Sang Baek

PY - 2017/7

Y1 - 2017/7

N2 - Purpose: Although γ-glutamyltransferase (GGT) is well known to be associated with metabolic syndrome (MS), prospective data on baseline and longitudinal changes in GGT levels and incident cases of MS are limited. We aimed to examine prospective associations between changes in GGT levels over time, as well as at baseline, and incident MS in Korean adults. Materials and Methods: A total of 2579 Korean adults free of MS were followed up for 2.6 years. Data were collected from 2005- 2008 (baseline) and from 2008-2011 (follow-up). Serum GGT levels were determined by enzymatic methods. Results: During follow-up, 558 participants (21.6%) developed MS. A gradual increase in the incidence of MS was observed across GGT quartiles. After adjustment for confounding factors, the odds ratio and 95% confidence interval (CI) for new onset MS, comparing the highest to the lowest quartiles of baseline GGT, was 2.07 (95% CI: 1.52-2.80). The odds ratio for the highest GGT changes (>4 IU/L increase) in comparison to the lowest GGT changes (<-5 IU/L decrease) was 1.75 (95% CI: 1.32-2.33). Among participants with baseline GGT concentrations

AB - Purpose: Although γ-glutamyltransferase (GGT) is well known to be associated with metabolic syndrome (MS), prospective data on baseline and longitudinal changes in GGT levels and incident cases of MS are limited. We aimed to examine prospective associations between changes in GGT levels over time, as well as at baseline, and incident MS in Korean adults. Materials and Methods: A total of 2579 Korean adults free of MS were followed up for 2.6 years. Data were collected from 2005- 2008 (baseline) and from 2008-2011 (follow-up). Serum GGT levels were determined by enzymatic methods. Results: During follow-up, 558 participants (21.6%) developed MS. A gradual increase in the incidence of MS was observed across GGT quartiles. After adjustment for confounding factors, the odds ratio and 95% confidence interval (CI) for new onset MS, comparing the highest to the lowest quartiles of baseline GGT, was 2.07 (95% CI: 1.52-2.80). The odds ratio for the highest GGT changes (>4 IU/L increase) in comparison to the lowest GGT changes (<-5 IU/L decrease) was 1.75 (95% CI: 1.32-2.33). Among participants with baseline GGT concentrations

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