Combined effects of whey protein hydrolysates and probiotics on oxidative stress induced by an iron-overloaded diet in rats

Eunju Park, Hyun Dong Paik, Seung Min Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Whey proteins possess antioxidant properties, and probiotics have various health-promoting effects. We investigated the effects of whey protein hydrolysates (WPHs) and probiotics in rats exposed to oxidative stress induced by iron-overload diet (IOL). Rats were divided into control (CTRL), IOL (0.2% ferrous sulphate), WPH (10%), probiotic (PB) mixture (Lactococcus lactis NK34 and B. polyfermenticus SCD), and WPH + PB group for 6 weeks. Average leukocytes and colonocytes tail moments were increased in IOL compared to CTRL but decreased in other groups. Conjugated diene was lower in WPH, PB, and WPH + PB than in IOL. Only WPH + PB group could recover glutathione S-transferase (GST) levels. SOD levels were recovered by WPH and PB. PB and WPH + PB increased α-tocopherol and only WPH + PB increased γ-tocopherol. Thus, our data demonstrated that WPH and PB exhibit antioxidant properties in a rat model of high-iron diet-induced oxidative stress and combination of them may provide an enhanced effect.

Original languageEnglish
Pages (from-to)298-307
Number of pages10
JournalInternational Journal of Food Sciences and Nutrition
Volume69
Issue number3
DOIs
Publication statusPublished - 2018 Apr 3

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Protein Hydrolysates
protein hydrolysates
Probiotics
whey protein
probiotics
Oxidative Stress
oxidative stress
Iron
iron
Diet
rats
diet
iron overload
Iron Overload
ferrous sulfate
Tocopherols
tocopherols
Whey Proteins
Antioxidants
antioxidants

All Science Journal Classification (ASJC) codes

  • Food Science

Cite this

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abstract = "Whey proteins possess antioxidant properties, and probiotics have various health-promoting effects. We investigated the effects of whey protein hydrolysates (WPHs) and probiotics in rats exposed to oxidative stress induced by iron-overload diet (IOL). Rats were divided into control (CTRL), IOL (0.2{\%} ferrous sulphate), WPH (10{\%}), probiotic (PB) mixture (Lactococcus lactis NK34 and B. polyfermenticus SCD), and WPH + PB group for 6 weeks. Average leukocytes and colonocytes tail moments were increased in IOL compared to CTRL but decreased in other groups. Conjugated diene was lower in WPH, PB, and WPH + PB than in IOL. Only WPH + PB group could recover glutathione S-transferase (GST) levels. SOD levels were recovered by WPH and PB. PB and WPH + PB increased α-tocopherol and only WPH + PB increased γ-tocopherol. Thus, our data demonstrated that WPH and PB exhibit antioxidant properties in a rat model of high-iron diet-induced oxidative stress and combination of them may provide an enhanced effect.",
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Combined effects of whey protein hydrolysates and probiotics on oxidative stress induced by an iron-overloaded diet in rats. / Park, Eunju; Paik, Hyun Dong; Lee, Seung Min.

In: International Journal of Food Sciences and Nutrition, Vol. 69, No. 3, 03.04.2018, p. 298-307.

Research output: Contribution to journalArticle

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