Combined effects of whey protein hydrolysates and probiotics on oxidative stress induced by an iron-overloaded diet in rats

Eunju Park, Hyun Dong Paik, Seung Min Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Whey proteins possess antioxidant properties, and probiotics have various health-promoting effects. We investigated the effects of whey protein hydrolysates (WPHs) and probiotics in rats exposed to oxidative stress induced by iron-overload diet (IOL). Rats were divided into control (CTRL), IOL (0.2% ferrous sulphate), WPH (10%), probiotic (PB) mixture (Lactococcus lactis NK34 and B. polyfermenticus SCD), and WPH + PB group for 6 weeks. Average leukocytes and colonocytes tail moments were increased in IOL compared to CTRL but decreased in other groups. Conjugated diene was lower in WPH, PB, and WPH + PB than in IOL. Only WPH + PB group could recover glutathione S-transferase (GST) levels. SOD levels were recovered by WPH and PB. PB and WPH + PB increased α-tocopherol and only WPH + PB increased γ-tocopherol. Thus, our data demonstrated that WPH and PB exhibit antioxidant properties in a rat model of high-iron diet-induced oxidative stress and combination of them may provide an enhanced effect.

Original languageEnglish
Pages (from-to)298-307
Number of pages10
JournalInternational Journal of Food Sciences and Nutrition
Volume69
Issue number3
DOIs
Publication statusPublished - 2018 Apr 3

All Science Journal Classification (ASJC) codes

  • Food Science

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