Combined inhibitory effect of Curcuma xanthorrhiza extract and Xylitol on Streptococcus mutans and Actinomyces viscosus

Hae Sun Kim, Choong Ho Choi, Ho Keun Kwon, Baekil Kim

Research output: Contribution to journalArticle

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Abstract

This study evaluated the combined inhibitory effects of a Curcuma xanthorrhiza extract (CXE) and Xylitol on S. mutons and A. viscosus in vitro. Three series of experiments on S. mutons and A. viscosus were carried out. In the first series, the Minimum inhibitory concentrations (MICs) of CXE, Xylitol, and CXE mixed with Xylitol (CXE+Xylitol) against S. mutons and A. viscosus were determined. Second, the antibacterial effect and the rapid effectiveness of CXE, Xylitol, and CXE+Xylitol against those bacteria was evaluated as contacting for 1, 2, 5, and 10 minutes. Finally, The saccharolytic capability of S. mutons was examined using bovine teeth that had been pretreated with CXE (1%), Xylitol (1%), CXE+Xylitol (1%), chlorhexidine (1%) and distilled water, and rinsed with distilled water. The pretreated bovine teeth were layered with soft agar containing sucrose (5%), S. mutans and phenol red, as a pH indicator, and incubated. The MICs of CXE were 5 ppm on both bacterial species. Xylitol did not inhibit either species. The MICs of CXE+Xylitol were 10 and 5 ppm against S. mutans, A. viscosus, respectively. According to the rapid effectiveness, CXE completely inhibited the growth of bacteria but Xylitol did not. CXE+Xylitol could completely inhibit the growth of bacteria. An evaluation of the saccharolytic capability of S. mutans on bovine teeth revealed that distilled water and Xylitol could not inhibit bacterial fermentation. However, the bovine teeth containing CXE, CXE+Xylitol and chlorhexidine inhibited the fermentation of bacteria. These results show that CXE and CXE+Xylitol have a strong antibacterial effect on S. mutans and A. viscosus in vitro.

Original languageEnglish
Pages (from-to)861-864
Number of pages4
JournalKey Engineering Materials
Volume342-343
Publication statusPublished - 2007 Apr 16

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Xylitol
Bacteria
Fermentation
Water
Sugar (sucrose)
Phenols
Chlorhexidine
Experiments
Phenolsulfonphthalein

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)

Cite this

@article{e0f64af811f1465ea9bc78d043126614,
title = "Combined inhibitory effect of Curcuma xanthorrhiza extract and Xylitol on Streptococcus mutans and Actinomyces viscosus",
abstract = "This study evaluated the combined inhibitory effects of a Curcuma xanthorrhiza extract (CXE) and Xylitol on S. mutons and A. viscosus in vitro. Three series of experiments on S. mutons and A. viscosus were carried out. In the first series, the Minimum inhibitory concentrations (MICs) of CXE, Xylitol, and CXE mixed with Xylitol (CXE+Xylitol) against S. mutons and A. viscosus were determined. Second, the antibacterial effect and the rapid effectiveness of CXE, Xylitol, and CXE+Xylitol against those bacteria was evaluated as contacting for 1, 2, 5, and 10 minutes. Finally, The saccharolytic capability of S. mutons was examined using bovine teeth that had been pretreated with CXE (1{\%}), Xylitol (1{\%}), CXE+Xylitol (1{\%}), chlorhexidine (1{\%}) and distilled water, and rinsed with distilled water. The pretreated bovine teeth were layered with soft agar containing sucrose (5{\%}), S. mutans and phenol red, as a pH indicator, and incubated. The MICs of CXE were 5 ppm on both bacterial species. Xylitol did not inhibit either species. The MICs of CXE+Xylitol were 10 and 5 ppm against S. mutans, A. viscosus, respectively. According to the rapid effectiveness, CXE completely inhibited the growth of bacteria but Xylitol did not. CXE+Xylitol could completely inhibit the growth of bacteria. An evaluation of the saccharolytic capability of S. mutans on bovine teeth revealed that distilled water and Xylitol could not inhibit bacterial fermentation. However, the bovine teeth containing CXE, CXE+Xylitol and chlorhexidine inhibited the fermentation of bacteria. These results show that CXE and CXE+Xylitol have a strong antibacterial effect on S. mutans and A. viscosus in vitro.",
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Combined inhibitory effect of Curcuma xanthorrhiza extract and Xylitol on Streptococcus mutans and Actinomyces viscosus. / Kim, Hae Sun; Choi, Choong Ho; Kwon, Ho Keun; Kim, Baekil.

In: Key Engineering Materials, Vol. 342-343, 16.04.2007, p. 861-864.

Research output: Contribution to journalArticle

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AB - This study evaluated the combined inhibitory effects of a Curcuma xanthorrhiza extract (CXE) and Xylitol on S. mutons and A. viscosus in vitro. Three series of experiments on S. mutons and A. viscosus were carried out. In the first series, the Minimum inhibitory concentrations (MICs) of CXE, Xylitol, and CXE mixed with Xylitol (CXE+Xylitol) against S. mutons and A. viscosus were determined. Second, the antibacterial effect and the rapid effectiveness of CXE, Xylitol, and CXE+Xylitol against those bacteria was evaluated as contacting for 1, 2, 5, and 10 minutes. Finally, The saccharolytic capability of S. mutons was examined using bovine teeth that had been pretreated with CXE (1%), Xylitol (1%), CXE+Xylitol (1%), chlorhexidine (1%) and distilled water, and rinsed with distilled water. The pretreated bovine teeth were layered with soft agar containing sucrose (5%), S. mutans and phenol red, as a pH indicator, and incubated. The MICs of CXE were 5 ppm on both bacterial species. Xylitol did not inhibit either species. The MICs of CXE+Xylitol were 10 and 5 ppm against S. mutans, A. viscosus, respectively. According to the rapid effectiveness, CXE completely inhibited the growth of bacteria but Xylitol did not. CXE+Xylitol could completely inhibit the growth of bacteria. An evaluation of the saccharolytic capability of S. mutans on bovine teeth revealed that distilled water and Xylitol could not inhibit bacterial fermentation. However, the bovine teeth containing CXE, CXE+Xylitol and chlorhexidine inhibited the fermentation of bacteria. These results show that CXE and CXE+Xylitol have a strong antibacterial effect on S. mutans and A. viscosus in vitro.

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