Combined intravitreal melphalan and intravenous/intra-arterial chemotherapy for retinoblastoma with vitreous seeds

Ji Hwan Lee, Jung Woo Han, Seung Min Hahn, Chuhl Joo Lyu, Dong Joon Kim, Sung Chul Lee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: We aimed to evaluate the therapeutic effect and complications of combined intravitreal melphalan and intravenous/intra-arterial chemotherapy as a primary approach for retinoblastoma with vitreous seeds. Methods: In this retrospective case series, eight eyes from eight retinoblastoma patients with vitreous seeds were included. All eyes received 20–30 μg of intravitreal melphalan accompanied by intravenous and intra-arterial chemotherapy. Triple freeze-thaw cryotherapy was performed when withdrawing the needle from the eye to prevent tumor dissemination. Results: Tumors and vitreous seeds regressed in all eyes. The mean number of intravitreal melphalan injections was 3.25 (median 3.50, range 2–4). Globe salvage was attained in seven of eight eyes (87.5 %). Enucleation was performed in one case, in which the pathologic section showed no residual tumor and tumor-free resection margins. Serous retinal detachment was observed in four eyes (50 %), and vitreous hemorrhage developed in two (25 %). Retinal pigment epithelium atrophy or mottling was found in three eyes (37.5 %). There were no cases of extraocular tumor extension or remote metastasis. Conclusions: Combined intravitreal melphalan and intravenous/intra-arterial chemotherapy was effective for tumor and vitreous seeding control, but vision-threatening complications such as vitreous hemorrhage or serous retinal detachment occurred in half the cases.

Original languageEnglish
Pages (from-to)391-394
Number of pages4
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume254
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1

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Melphalan
Retinoblastoma
Seeds
Drug Therapy
Vitreous Hemorrhage
Retinal Detachment
Neoplasms
Eye Hemorrhage
Intravitreal Injections
Cryotherapy
Retinal Pigment Epithelium
Residual Neoplasm
Therapeutic Uses
Atrophy
Needles
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Lee, Ji Hwan ; Han, Jung Woo ; Hahn, Seung Min ; Lyu, Chuhl Joo ; Kim, Dong Joon ; Lee, Sung Chul. / Combined intravitreal melphalan and intravenous/intra-arterial chemotherapy for retinoblastoma with vitreous seeds. In: Graefe's Archive for Clinical and Experimental Ophthalmology. 2016 ; Vol. 254, No. 2. pp. 391-394.
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abstract = "Purpose: We aimed to evaluate the therapeutic effect and complications of combined intravitreal melphalan and intravenous/intra-arterial chemotherapy as a primary approach for retinoblastoma with vitreous seeds. Methods: In this retrospective case series, eight eyes from eight retinoblastoma patients with vitreous seeds were included. All eyes received 20–30 μg of intravitreal melphalan accompanied by intravenous and intra-arterial chemotherapy. Triple freeze-thaw cryotherapy was performed when withdrawing the needle from the eye to prevent tumor dissemination. Results: Tumors and vitreous seeds regressed in all eyes. The mean number of intravitreal melphalan injections was 3.25 (median 3.50, range 2–4). Globe salvage was attained in seven of eight eyes (87.5 {\%}). Enucleation was performed in one case, in which the pathologic section showed no residual tumor and tumor-free resection margins. Serous retinal detachment was observed in four eyes (50 {\%}), and vitreous hemorrhage developed in two (25 {\%}). Retinal pigment epithelium atrophy or mottling was found in three eyes (37.5 {\%}). There were no cases of extraocular tumor extension or remote metastasis. Conclusions: Combined intravitreal melphalan and intravenous/intra-arterial chemotherapy was effective for tumor and vitreous seeding control, but vision-threatening complications such as vitreous hemorrhage or serous retinal detachment occurred in half the cases.",
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Combined intravitreal melphalan and intravenous/intra-arterial chemotherapy for retinoblastoma with vitreous seeds. / Lee, Ji Hwan; Han, Jung Woo; Hahn, Seung Min; Lyu, Chuhl Joo; Kim, Dong Joon; Lee, Sung Chul.

In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 254, No. 2, 01.02.2016, p. 391-394.

Research output: Contribution to journalArticle

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