Combined Therapeutic Strategies for Keloid Treatment

Young In Lee, Jihee Kim, Chae Eun Yang, Jong Won Hong, Won Jai Lee, Ju Hee Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

BACKGROUNDRecent advances in keloid management favor the administration of combination therapy over monotherapy.OBJECTIVEThe authors evaluated the safety and efficacy of combination therapy to treat keloids using fractional lasers, cryotherapy, and intralesional corticosteroids.MATERIALS AND METHODSThe authors performed a retrospective study involving 35 Korean patients. Each patient underwent treatment using the 1,550 nm nonablative fractional erbium-glass laser, followed by the 10,600 nm ablative fractional carbon dioxide laser. Laser treatment was immediately followed by the administration of superficial cryotherapy and intralesional triamcinolone injection. Therapeutic efficacy was assessed using the Vancouver Scar Scale (VSS) score and the 7-point patient self-assessment score.RESULTSThe mean total and subcategory VSS scores showed statistically significant improvements. The height and pliability scores showed the most significant and quickest responses to the combination therapy. The patients reported remarkable improvement in itching, pain, and limitations of motion after a single combination therapy session. Twenty patients were followed up for 1 year after the discontinuation of the combination treatment, and the recurrence was observed only in one patient. No significant adverse effects were observed throughout the follow-up period.CONCLUSIONCombination keloid therapy using fractional lasers, superficial cryotherapy, and intralesional triamcinolone injection is safe and more effective than individual monotherapies.

Original languageEnglish
Pages (from-to)802-810
Number of pages9
JournalDermatologic Surgery
Volume45
Issue number6
DOIs
Publication statusPublished - 2019 Jun 1

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Keloid
Cryotherapy
Lasers
Intralesional Injections
Triamcinolone
Therapeutics
Cicatrix
Erbium
Gas Lasers
Pruritus
Pliability
Glass
Adrenal Cortex Hormones
Retrospective Studies
Safety
Recurrence
Pain

All Science Journal Classification (ASJC) codes

  • Surgery
  • Dermatology

Cite this

Lee, Young In ; Kim, Jihee ; Yang, Chae Eun ; Hong, Jong Won ; Lee, Won Jai ; Lee, Ju Hee. / Combined Therapeutic Strategies for Keloid Treatment. In: Dermatologic Surgery. 2019 ; Vol. 45, No. 6. pp. 802-810.
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abstract = "BACKGROUNDRecent advances in keloid management favor the administration of combination therapy over monotherapy.OBJECTIVEThe authors evaluated the safety and efficacy of combination therapy to treat keloids using fractional lasers, cryotherapy, and intralesional corticosteroids.MATERIALS AND METHODSThe authors performed a retrospective study involving 35 Korean patients. Each patient underwent treatment using the 1,550 nm nonablative fractional erbium-glass laser, followed by the 10,600 nm ablative fractional carbon dioxide laser. Laser treatment was immediately followed by the administration of superficial cryotherapy and intralesional triamcinolone injection. Therapeutic efficacy was assessed using the Vancouver Scar Scale (VSS) score and the 7-point patient self-assessment score.RESULTSThe mean total and subcategory VSS scores showed statistically significant improvements. The height and pliability scores showed the most significant and quickest responses to the combination therapy. The patients reported remarkable improvement in itching, pain, and limitations of motion after a single combination therapy session. Twenty patients were followed up for 1 year after the discontinuation of the combination treatment, and the recurrence was observed only in one patient. No significant adverse effects were observed throughout the follow-up period.CONCLUSIONCombination keloid therapy using fractional lasers, superficial cryotherapy, and intralesional triamcinolone injection is safe and more effective than individual monotherapies.",
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Lee, YI, Kim, J, Yang, CE, Hong, JW, Lee, WJ & Lee, JH 2019, 'Combined Therapeutic Strategies for Keloid Treatment', Dermatologic Surgery, vol. 45, no. 6, pp. 802-810. https://doi.org/10.1097/DSS.0000000000001695

Combined Therapeutic Strategies for Keloid Treatment. / Lee, Young In; Kim, Jihee; Yang, Chae Eun; Hong, Jong Won; Lee, Won Jai; Lee, Ju Hee.

In: Dermatologic Surgery, Vol. 45, No. 6, 01.06.2019, p. 802-810.

Research output: Contribution to journalArticle

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T1 - Combined Therapeutic Strategies for Keloid Treatment

AU - Lee, Young In

AU - Kim, Jihee

AU - Yang, Chae Eun

AU - Hong, Jong Won

AU - Lee, Won Jai

AU - Lee, Ju Hee

PY - 2019/6/1

Y1 - 2019/6/1

N2 - BACKGROUNDRecent advances in keloid management favor the administration of combination therapy over monotherapy.OBJECTIVEThe authors evaluated the safety and efficacy of combination therapy to treat keloids using fractional lasers, cryotherapy, and intralesional corticosteroids.MATERIALS AND METHODSThe authors performed a retrospective study involving 35 Korean patients. Each patient underwent treatment using the 1,550 nm nonablative fractional erbium-glass laser, followed by the 10,600 nm ablative fractional carbon dioxide laser. Laser treatment was immediately followed by the administration of superficial cryotherapy and intralesional triamcinolone injection. Therapeutic efficacy was assessed using the Vancouver Scar Scale (VSS) score and the 7-point patient self-assessment score.RESULTSThe mean total and subcategory VSS scores showed statistically significant improvements. The height and pliability scores showed the most significant and quickest responses to the combination therapy. The patients reported remarkable improvement in itching, pain, and limitations of motion after a single combination therapy session. Twenty patients were followed up for 1 year after the discontinuation of the combination treatment, and the recurrence was observed only in one patient. No significant adverse effects were observed throughout the follow-up period.CONCLUSIONCombination keloid therapy using fractional lasers, superficial cryotherapy, and intralesional triamcinolone injection is safe and more effective than individual monotherapies.

AB - BACKGROUNDRecent advances in keloid management favor the administration of combination therapy over monotherapy.OBJECTIVEThe authors evaluated the safety and efficacy of combination therapy to treat keloids using fractional lasers, cryotherapy, and intralesional corticosteroids.MATERIALS AND METHODSThe authors performed a retrospective study involving 35 Korean patients. Each patient underwent treatment using the 1,550 nm nonablative fractional erbium-glass laser, followed by the 10,600 nm ablative fractional carbon dioxide laser. Laser treatment was immediately followed by the administration of superficial cryotherapy and intralesional triamcinolone injection. Therapeutic efficacy was assessed using the Vancouver Scar Scale (VSS) score and the 7-point patient self-assessment score.RESULTSThe mean total and subcategory VSS scores showed statistically significant improvements. The height and pliability scores showed the most significant and quickest responses to the combination therapy. The patients reported remarkable improvement in itching, pain, and limitations of motion after a single combination therapy session. Twenty patients were followed up for 1 year after the discontinuation of the combination treatment, and the recurrence was observed only in one patient. No significant adverse effects were observed throughout the follow-up period.CONCLUSIONCombination keloid therapy using fractional lasers, superficial cryotherapy, and intralesional triamcinolone injection is safe and more effective than individual monotherapies.

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