Combined treatment of an intratumoral injection of dendritic cells and systemic chemotherapy (paclitaxel) for murine fibrosarcoma

Gwang Seong Choi, Moon Hee Lee, Soon Ki Kim, Chul Soo Kim, Hong Sik Lee, Moon Whan Im, Hye Yun Kil, Do Hwan Seong, Jong Rok Lee, Woo Chul Kim, Min Geol Lee, Sun U. Song

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Abstract

A novel combined treatment of conventional chemotherapy with an intratumoral injection of syngeneic dendritic cells (DCs) has emerged as a potent cancer treatment strategy. In this study, we evaluated the synergistic effect of an intraperitoneal (i.p.) injection of a chemotherapeutic drug, paclitaxel, and an intratumoral (i.t.) injection of syngeneic bone marrow-derived DCs for the treatment of pre-existing fibrosarcoma. Subcutaneous tumors were established using MCA102 fibrosarcoma cells in syngeneic C57BL/6 mice. The results demonstrated that the combined treatment of paclitaxel chemotherapy and the injection of DCs led to complete tumor regression, in contrast to only partial eradication of the tumors with chemotherapy or DCs alone. Furthermore, the tumo-free mice were able to resist a repeat challenge with tile same type of tumor. These findings suggest that a combination therapy of systemic chemotherapy along with the intratumoral administration of DCs is a potent treatment strategy for fibrosarcoma.

Original languageEnglish
Pages (from-to)835-842
Number of pages8
JournalYonsei medical journal
Volume46
Issue number6
DOIs
Publication statusPublished - 2005 Dec

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Choi, G. S., Lee, M. H., Kim, S. K., Kim, C. S., Lee, H. S., Im, M. W., Kil, H. Y., Seong, D. H., Lee, J. R., Kim, W. C., Lee, M. G., & Song, S. U. (2005). Combined treatment of an intratumoral injection of dendritic cells and systemic chemotherapy (paclitaxel) for murine fibrosarcoma. Yonsei medical journal, 46(6), 835-842. https://doi.org/10.3349/ymj.2005.46.6.835