Combined use of basal insulin analog and acarbose reduces postprandial glucose in patients with uncontrolled type 2 diabetes

Ji Hyun Kim, Ji Hyun Ahn, Soo Kyung Kim, Dae Ho Lee, Hye Soon Kim, Ho Sang Shon, Hyun Jeong Jeon, Tae Hwa Kim, Yong Wook Cho, Jae Taek Kim, Sung Min Han, Choon Hee Chung, Ohk Hyun Ryu, Jae Min Lee, Soon Hee Lee, Min Jeong Kwon, Tae kyun Kim, Il Seong Namgoong, Eun Sook Kim, In Kyung JungSung Dae Moon, Je Ho Han, Chong Hwa Kim, Eun Hee Cho, Ki Young Kim, Hee Baek Park, Ki Sang Lee, Sung Woo Lee, Sang Cheol Lee, Cheol Min Kang, Byung Sook Jeon, Min Seop Song, Seung Baik Yun, Hyung Keun Chung, Jong Ho Seong, Jin Yi Jeong, Bong Yun Cha

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Abstract

Aims/Introduction: Early initiation of basal insulin therapy is recommended for normalizing fasting blood glucose in type 2 diabetes mellitus. However, basal insulin treatment might not adequately control postprandial glucose levels. The present study evaluated whether the combination of the α-glucosidase inhibitor, acarbose, and basal insulin improved blood glucose control under daily-life treatment conditions in a large sample of Korean patients. Materials and Methods: The present study was a multicenter, prospective, observational study under daily-life treatment conditions. A total of 539 patients with type 2 diabetes who were treated with basal insulin and additional acarbose were enrolled and followed up for 20 weeks. Changes in hemoglobin A1c, fasting and postprandial blood glucose were evaluated at baseline and at the end of the observation period. The physician and patient satisfaction of the combination treatment and safety were assessed. Results: Hemoglobin A1c decreased by 0.55 ± 1.05% from baseline (P < 0.0001). Fasting and postprandial blood glucose levels were reduced by 0.89 ± 3.79 and 2.59 ± 4.77 mmol/L (both P < 0.0001). The most frequently reported adverse drug reactions were flatulence (0.37%) and abnormal gastrointestinal sounds (0.37%), and all were mild in intensity and transient. In the satisfaction evaluation, 79.0% of physicians and 77.3% of patients were 'very satisfied' or 'satisfied' with the combined basal insulin and acarbose therapy. Conclusions: Combination therapy of basal insulin and acarbose in patients with type 2 diabetes improved glucose control, and had no drug-specific safety concerns, suggesting that the treatment might benefit individuals who cannot control blood glucose with basal insulin alone.

Original languageEnglish
Pages (from-to)219-226
Number of pages8
JournalJournal of Diabetes Investigation
Volume6
Issue number2
DOIs
Publication statusPublished - 2015 Mar 1

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All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Kim, J. H., Ahn, J. H., Kim, S. K., Lee, D. H., Kim, H. S., Shon, H. S., Jeon, H. J., Kim, T. H., Cho, Y. W., Kim, J. T., Han, S. M., Chung, C. H., Ryu, O. H., Lee, J. M., Lee, S. H., Kwon, M. J., Kim, T. K., Namgoong, I. S., Kim, E. S., ... Cha, B. Y. (2015). Combined use of basal insulin analog and acarbose reduces postprandial glucose in patients with uncontrolled type 2 diabetes. Journal of Diabetes Investigation, 6(2), 219-226. https://doi.org/10.1111/jdi.12261