Combined use of energy-based interventions with low-dose isotretinoin for the treatment of inflammatory acne: An retrospective cohort analysis

Jemin Kim, Tunyaporn Jongudomsombat, Young In Lee, Jihee Kim, Sang Ho Oh, Jong Won Hong, Ju Hee Lee

Research output: Contribution to journalArticlepeer-review


Background: The combined use of oral isotretinoin with energy-based interventions including fractional microneedle radiofrequency, pulsed dye laser, and ablative fractional laser is an effective way to treat moderate-to-severe inflammatory acne lesions. However, studies regarding its efficacy and safety are limited. Aims: This study aimed to assess the efficacy and safety of a treatment using low-dose isotretinoin with energy-based interventions for inflammatory acne. Patients and Methods: This retrospective cohort study included 126 patients who were diagnosed with inflammatory acne and were treated with systemic isotretinoin for at least 3 months. Patients were divided into EBD (energy-based intervention) (n = 82) and non-EBD groups (n = 44). Clinical outcomes of both groups were assessed using medical records and digital photographs. Results: After treatment, the modified Global Acne Grading Score of the EBD and non-EBD groups decreased by 35.1 ± 17.2 and 25.6 ± 10.1, respectively. The improvement in acne severity was significantly greater in the EBD group than in the non-EBD group. Cumulated isotretinoin dose and frequency of drug-related side effects were significantly higher in the non-EBD group than in the EBD group. Conclusion: Combined treatment with low-dose isotretinoin and energy-based intervention is well tolerated and associated with positive responses in patients with inflammatory acne.

Original languageEnglish
Pages (from-to)4383-4391
Number of pages9
JournalJournal of Cosmetic Dermatology
Issue number10
Publication statusPublished - 2022 Oct

Bibliographical note

Funding Information:
This work was supported by a grant from the Korea Mental Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HP20C0171), the Yonsei University Faculty Research Grant (6‐2020‐0081), and the Korea Medical Device Development Fund grant funded by the Korea Government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Evergy, the Ministry of Health & Welfare, Republic of Korea, the Ministry of Food and Drug Safety) (Project Number: 202014X4502)

Publisher Copyright:
© 2022 Wiley Periodicals LLC.

All Science Journal Classification (ASJC) codes

  • Dermatology


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