Comorbidities of nontuberculous mycobacteria infection in Korean adults: results from the National Health Insurance Service–National Sample Cohort (NHIS–NSC) database

Seung Won Lee, Youngmok Park, Sol Kim, Eun Ki Chung, Young Ae Kang

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Background: The global prevalence and incidence of nontuberculous mycobacteria (NTM) infection are increasing. However, the prevalence of NTM infection-associated comorbidities remains understudied. Thus, we investigated the comorbidities associated with NTM infection using the National Health Insurance Service-National Sample Cohort (NHIS–NSC) 2.0 database of the National Health Insurance Service (NHIS). Methods: In this case–control study, patients with NTM infection and controls aged 20–89 years of age were matched 1:4 by sex, age, region, and income. A total of 26 comorbidities were selected based on previous reports and claims data analysis. The distribution of comorbidities was compared between patients with NTM infection and controls by sex and age using logistic regression analysis. Results: In total, 893 patients (379 men and 514 women) with NTM infection (mean age, 56.1 years) and 3,572 controls (mean age, 55.6 years) were included. The odds ratio for prevalence of respiratory diseases, metabolic diseases, musculoskeletal disorders, gastrointestinal diseases, skin diseases, mental diseases, and neoplasms was significantly higher in patients with NTM infection than in the control group. Among comorbid diseases, the odds ratios (ORs) for the prevalence of the respiratory diseases such as bronchiectasis (OR [95% confidence interval (CI)]: 26.79 [19.69–36.45]) and interstitial pneumonitis (OR [95% CI]: 15.10 [7.15–31.89]) were the highest. No significant differences were observed in NTM infection-related comorbidities between men and women. In the younger age group (20–39 years old), the prevalence of respiratory and systemic diseases such as hypertension and diabetes was higher in the patient group than in the control group. Conclusions: NTM infection is associated with several respiratory and systemic diseases that should be considered when providing medical care to patients with NTM infection.

Original languageEnglish
Article number283
JournalBMC pulmonary medicine
Issue number1
Publication statusPublished - 2022 Dec

Bibliographical note

Funding Information:
The authors would like to thank the Korea National Health Insurance Service for providing the data used for analysis.

Funding Information:
This study was supported by the research projects “Sustainable, climate‐neutral and resource‐efficient forest‐based bioeconomy,” funded by the Academy of Finland, Strategic Research Council (decision no. 314224) and “Wood‐based products in low‐carbon economy: Dynamics of substitution processes and their climate impacts,” funded by the Academy of Finland (decision no. 321627). The authors wish to thank all the experts who took the survey as well as three anonymous reviewers whose comments helped to significantly improve the manuscript.

Publisher Copyright:
© 2022, The Author(s).

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine


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