Comparable characteristics of tuberculous and non-tuberculous mycobacterial cavitary lung diseases

YoungKeun Kim, S. Hahn, Y. Uh, D. J. Im, Y. L. Lim, H. K. Choi, H. Y. Kim

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Abstract

OBJECTIVE: To identify characteristics that differentiate lung disease due to non-tuberculous mycobacteria (NTM) from that due to pulmonary tuberculosis (PTB) in acid-fast bacilli (AFB) smear-positive patients with lung cavities. METHODS: From 2006 to 2012, 142 AFB smear- and culture-positive patients with lung cavities were identified at the Wonju Severance Christian Hospital, Wonju, Korea. Clinical and radiographic characteristics were compared between patients withNTMdisease and PTB. RESULTS: Of 142 patients, 112 were diagnosed with PTB and 30 with NTM disease. Patients with NTM disease were older (62 vs. 49 years, P = 0.001), more likely to have had previous anti-tuberculosis treatment (18, 60.0% vs. 34, 30.6%; P = 0.001), more likely to have haemoptysis (9, 30.0% vs. 13, 11.9%; P = 0.022) and less likely to have consolidation on chest radiograph (20, 66.7% vs. 98, 87.5%; P = 0.007) than PTB patients. Multivariate analysis showed that age ≥65 years (OR 3.37, 95%CI 1.24-9.13, P = 0.010) and previous antituberculosis treatment (OR 3.75, 95%CI 1.46-9.65, P = 0.006) were significantly associated with NTM disease. CONCLUSIONS: Cavitary patients with positive AFB smears and NTM or PTB had considerable overlapping clinical characteristics, although patients aged ≥65 years or with a previous history of anti-tuberculosis treatment were more likely to have NTM.

Original languageEnglish
JournalInternational Journal of Tuberculosis and Lung Disease
Volume18
Issue number6
DOIs
Publication statusPublished - 2014 Jun 1

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Lung Diseases
Mycobacterium
Pulmonary Tuberculosis
Bacillus
Acids
Tuberculosis
Lung
Hemoptysis
Korea
Mycobacterium tuberculosis
Thorax
Therapeutics
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

@article{e60d93a3d988422fb27d80d9db522851,
title = "Comparable characteristics of tuberculous and non-tuberculous mycobacterial cavitary lung diseases",
abstract = "OBJECTIVE: To identify characteristics that differentiate lung disease due to non-tuberculous mycobacteria (NTM) from that due to pulmonary tuberculosis (PTB) in acid-fast bacilli (AFB) smear-positive patients with lung cavities. METHODS: From 2006 to 2012, 142 AFB smear- and culture-positive patients with lung cavities were identified at the Wonju Severance Christian Hospital, Wonju, Korea. Clinical and radiographic characteristics were compared between patients withNTMdisease and PTB. RESULTS: Of 142 patients, 112 were diagnosed with PTB and 30 with NTM disease. Patients with NTM disease were older (62 vs. 49 years, P = 0.001), more likely to have had previous anti-tuberculosis treatment (18, 60.0{\%} vs. 34, 30.6{\%}; P = 0.001), more likely to have haemoptysis (9, 30.0{\%} vs. 13, 11.9{\%}; P = 0.022) and less likely to have consolidation on chest radiograph (20, 66.7{\%} vs. 98, 87.5{\%}; P = 0.007) than PTB patients. Multivariate analysis showed that age ≥65 years (OR 3.37, 95{\%}CI 1.24-9.13, P = 0.010) and previous antituberculosis treatment (OR 3.75, 95{\%}CI 1.46-9.65, P = 0.006) were significantly associated with NTM disease. CONCLUSIONS: Cavitary patients with positive AFB smears and NTM or PTB had considerable overlapping clinical characteristics, although patients aged ≥65 years or with a previous history of anti-tuberculosis treatment were more likely to have NTM.",
author = "YoungKeun Kim and S. Hahn and Y. Uh and Im, {D. J.} and Lim, {Y. L.} and Choi, {H. K.} and Kim, {H. Y.}",
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Comparable characteristics of tuberculous and non-tuberculous mycobacterial cavitary lung diseases. / Kim, YoungKeun; Hahn, S.; Uh, Y.; Im, D. J.; Lim, Y. L.; Choi, H. K.; Kim, H. Y.

In: International Journal of Tuberculosis and Lung Disease, Vol. 18, No. 6, 01.06.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparable characteristics of tuberculous and non-tuberculous mycobacterial cavitary lung diseases

AU - Kim, YoungKeun

AU - Hahn, S.

AU - Uh, Y.

AU - Im, D. J.

AU - Lim, Y. L.

AU - Choi, H. K.

AU - Kim, H. Y.

PY - 2014/6/1

Y1 - 2014/6/1

N2 - OBJECTIVE: To identify characteristics that differentiate lung disease due to non-tuberculous mycobacteria (NTM) from that due to pulmonary tuberculosis (PTB) in acid-fast bacilli (AFB) smear-positive patients with lung cavities. METHODS: From 2006 to 2012, 142 AFB smear- and culture-positive patients with lung cavities were identified at the Wonju Severance Christian Hospital, Wonju, Korea. Clinical and radiographic characteristics were compared between patients withNTMdisease and PTB. RESULTS: Of 142 patients, 112 were diagnosed with PTB and 30 with NTM disease. Patients with NTM disease were older (62 vs. 49 years, P = 0.001), more likely to have had previous anti-tuberculosis treatment (18, 60.0% vs. 34, 30.6%; P = 0.001), more likely to have haemoptysis (9, 30.0% vs. 13, 11.9%; P = 0.022) and less likely to have consolidation on chest radiograph (20, 66.7% vs. 98, 87.5%; P = 0.007) than PTB patients. Multivariate analysis showed that age ≥65 years (OR 3.37, 95%CI 1.24-9.13, P = 0.010) and previous antituberculosis treatment (OR 3.75, 95%CI 1.46-9.65, P = 0.006) were significantly associated with NTM disease. CONCLUSIONS: Cavitary patients with positive AFB smears and NTM or PTB had considerable overlapping clinical characteristics, although patients aged ≥65 years or with a previous history of anti-tuberculosis treatment were more likely to have NTM.

AB - OBJECTIVE: To identify characteristics that differentiate lung disease due to non-tuberculous mycobacteria (NTM) from that due to pulmonary tuberculosis (PTB) in acid-fast bacilli (AFB) smear-positive patients with lung cavities. METHODS: From 2006 to 2012, 142 AFB smear- and culture-positive patients with lung cavities were identified at the Wonju Severance Christian Hospital, Wonju, Korea. Clinical and radiographic characteristics were compared between patients withNTMdisease and PTB. RESULTS: Of 142 patients, 112 were diagnosed with PTB and 30 with NTM disease. Patients with NTM disease were older (62 vs. 49 years, P = 0.001), more likely to have had previous anti-tuberculosis treatment (18, 60.0% vs. 34, 30.6%; P = 0.001), more likely to have haemoptysis (9, 30.0% vs. 13, 11.9%; P = 0.022) and less likely to have consolidation on chest radiograph (20, 66.7% vs. 98, 87.5%; P = 0.007) than PTB patients. Multivariate analysis showed that age ≥65 years (OR 3.37, 95%CI 1.24-9.13, P = 0.010) and previous antituberculosis treatment (OR 3.75, 95%CI 1.46-9.65, P = 0.006) were significantly associated with NTM disease. CONCLUSIONS: Cavitary patients with positive AFB smears and NTM or PTB had considerable overlapping clinical characteristics, although patients aged ≥65 years or with a previous history of anti-tuberculosis treatment were more likely to have NTM.

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U2 - 10.5588/ijtld.13.0871

DO - 10.5588/ijtld.13.0871

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