Comparative effects of non-thermal atmospheric pressure plasma on migration and invasion in oral squamous cell cancer, by gas type

Sung Un Kang, Seong Jin Seo, Yeon Soo Kim, Yoo Seob Shin, Yoonwoo Koh, Chang Min Lee, Sang Sik Yang, Jong Soo Lee, Eunpyo Moon, Hami Kang, Jeong Beom Ryeo, Yuijina Lee, Chul Ho Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: The fourth state of matter, plasma is known as an ionized gas with electrons, radicals and ions. The use of non-thermal plasma (NTP) in cancer research became possible because of the progresses in plasma medicine. Previous studies on the potential NTP-mediated cancer therapy have mainly concentrated on cancer cell apoptosis. In the present study, we compared the inhibitory effect of NTP on cell migration and invasion in the oral squamous cancer cell lines. Materials and Methods: We used oral squamous cancer cell lines (SCC1483, MSKQLL1) and different gases (N 2 , He, and Ar). To investigate the mechanism of plasma treatment, using different gases (N 2 , He, and Ar) which induces anti-migration and anti-invasion properties, we performed wound healing assay, invasion assay and gelatin zymography. Results: The results showed that NTP inhibits cancer cell migration and invasion of oral squamous cancer cell. In addition, focal adhesion kinase expression and matrix metalloproteinase-2/9 activity were also inhibited. Conclusion: The suppression of cancer cell invasion by NTP varied depending on the type of gas. Comparison of the three gases revealed that N 2 NTP inhibited cell migration and invasion most potently via decreased expression of focal adhesion kinase and matrix metalloproteinase activity.

Original languageEnglish
Pages (from-to)272-281
Number of pages10
JournalYonsei medical journal
Volume58
Issue number2
DOIs
Publication statusPublished - 2017 Mar 1

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Plasma Gases
Squamous Cell Neoplasms
Mouth Neoplasms
Gases
Cell Movement
Focal Adhesion Protein-Tyrosine Kinases
Epithelial Cells
Neoplasms
Plasma Cells
Cell Line
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Gelatin
Matrix Metalloproteinases
Wound Healing
Medicine
Electrons
Ions
Apoptosis

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kang, Sung Un ; Seo, Seong Jin ; Kim, Yeon Soo ; Shin, Yoo Seob ; Koh, Yoonwoo ; Lee, Chang Min ; Yang, Sang Sik ; Lee, Jong Soo ; Moon, Eunpyo ; Kang, Hami ; Ryeo, Jeong Beom ; Lee, Yuijina ; Kim, Chul Ho. / Comparative effects of non-thermal atmospheric pressure plasma on migration and invasion in oral squamous cell cancer, by gas type. In: Yonsei medical journal. 2017 ; Vol. 58, No. 2. pp. 272-281.
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abstract = "Purpose: The fourth state of matter, plasma is known as an ionized gas with electrons, radicals and ions. The use of non-thermal plasma (NTP) in cancer research became possible because of the progresses in plasma medicine. Previous studies on the potential NTP-mediated cancer therapy have mainly concentrated on cancer cell apoptosis. In the present study, we compared the inhibitory effect of NTP on cell migration and invasion in the oral squamous cancer cell lines. Materials and Methods: We used oral squamous cancer cell lines (SCC1483, MSKQLL1) and different gases (N 2 , He, and Ar). To investigate the mechanism of plasma treatment, using different gases (N 2 , He, and Ar) which induces anti-migration and anti-invasion properties, we performed wound healing assay, invasion assay and gelatin zymography. Results: The results showed that NTP inhibits cancer cell migration and invasion of oral squamous cancer cell. In addition, focal adhesion kinase expression and matrix metalloproteinase-2/9 activity were also inhibited. Conclusion: The suppression of cancer cell invasion by NTP varied depending on the type of gas. Comparison of the three gases revealed that N 2 NTP inhibited cell migration and invasion most potently via decreased expression of focal adhesion kinase and matrix metalloproteinase activity.",
author = "Kang, {Sung Un} and Seo, {Seong Jin} and Kim, {Yeon Soo} and Shin, {Yoo Seob} and Yoonwoo Koh and Lee, {Chang Min} and Yang, {Sang Sik} and Lee, {Jong Soo} and Eunpyo Moon and Hami Kang and Ryeo, {Jeong Beom} and Yuijina Lee and Kim, {Chul Ho}",
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Kang, SU, Seo, SJ, Kim, YS, Shin, YS, Koh, Y, Lee, CM, Yang, SS, Lee, JS, Moon, E, Kang, H, Ryeo, JB, Lee, Y & Kim, CH 2017, 'Comparative effects of non-thermal atmospheric pressure plasma on migration and invasion in oral squamous cell cancer, by gas type', Yonsei medical journal, vol. 58, no. 2, pp. 272-281. https://doi.org/10.3349/ymj.2017.58.2.272

Comparative effects of non-thermal atmospheric pressure plasma on migration and invasion in oral squamous cell cancer, by gas type. / Kang, Sung Un; Seo, Seong Jin; Kim, Yeon Soo; Shin, Yoo Seob; Koh, Yoonwoo; Lee, Chang Min; Yang, Sang Sik; Lee, Jong Soo; Moon, Eunpyo; Kang, Hami; Ryeo, Jeong Beom; Lee, Yuijina; Kim, Chul Ho.

In: Yonsei medical journal, Vol. 58, No. 2, 01.03.2017, p. 272-281.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparative effects of non-thermal atmospheric pressure plasma on migration and invasion in oral squamous cell cancer, by gas type

AU - Kang, Sung Un

AU - Seo, Seong Jin

AU - Kim, Yeon Soo

AU - Shin, Yoo Seob

AU - Koh, Yoonwoo

AU - Lee, Chang Min

AU - Yang, Sang Sik

AU - Lee, Jong Soo

AU - Moon, Eunpyo

AU - Kang, Hami

AU - Ryeo, Jeong Beom

AU - Lee, Yuijina

AU - Kim, Chul Ho

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Purpose: The fourth state of matter, plasma is known as an ionized gas with electrons, radicals and ions. The use of non-thermal plasma (NTP) in cancer research became possible because of the progresses in plasma medicine. Previous studies on the potential NTP-mediated cancer therapy have mainly concentrated on cancer cell apoptosis. In the present study, we compared the inhibitory effect of NTP on cell migration and invasion in the oral squamous cancer cell lines. Materials and Methods: We used oral squamous cancer cell lines (SCC1483, MSKQLL1) and different gases (N 2 , He, and Ar). To investigate the mechanism of plasma treatment, using different gases (N 2 , He, and Ar) which induces anti-migration and anti-invasion properties, we performed wound healing assay, invasion assay and gelatin zymography. Results: The results showed that NTP inhibits cancer cell migration and invasion of oral squamous cancer cell. In addition, focal adhesion kinase expression and matrix metalloproteinase-2/9 activity were also inhibited. Conclusion: The suppression of cancer cell invasion by NTP varied depending on the type of gas. Comparison of the three gases revealed that N 2 NTP inhibited cell migration and invasion most potently via decreased expression of focal adhesion kinase and matrix metalloproteinase activity.

AB - Purpose: The fourth state of matter, plasma is known as an ionized gas with electrons, radicals and ions. The use of non-thermal plasma (NTP) in cancer research became possible because of the progresses in plasma medicine. Previous studies on the potential NTP-mediated cancer therapy have mainly concentrated on cancer cell apoptosis. In the present study, we compared the inhibitory effect of NTP on cell migration and invasion in the oral squamous cancer cell lines. Materials and Methods: We used oral squamous cancer cell lines (SCC1483, MSKQLL1) and different gases (N 2 , He, and Ar). To investigate the mechanism of plasma treatment, using different gases (N 2 , He, and Ar) which induces anti-migration and anti-invasion properties, we performed wound healing assay, invasion assay and gelatin zymography. Results: The results showed that NTP inhibits cancer cell migration and invasion of oral squamous cancer cell. In addition, focal adhesion kinase expression and matrix metalloproteinase-2/9 activity were also inhibited. Conclusion: The suppression of cancer cell invasion by NTP varied depending on the type of gas. Comparison of the three gases revealed that N 2 NTP inhibited cell migration and invasion most potently via decreased expression of focal adhesion kinase and matrix metalloproteinase activity.

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