Comparative evaluation of biphasic calcium phosphate and biphasic calcium phosphate collagen composite on osteoconductive potency in rabbit calvarial defect

Eun Ung Lee, Dong Ju Kim, Hyun Chang Lim, Jung Seok Lee, Ui Won Jung, Seong Ho Choi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: The aim of this study was to determine the osteoconductivity of biphasic calcium phosphate collagen composite (BCPC) in rabbit calvarial defect model by comparing with biphasic calcium phosphate (BCP). Four 8 mm diameter bicortical calvarial defects were made in ten rabbits. Each of the defects was randomly assigned and filled with 1) collagen sponge, 2) BCP, 3) BCPC, and 4) nothing as control. The animals were sacrificed at either 2 weeks (n = 5) or 8 weeks (n = 5) healing period. Results: All groups showed wedge shaped new bone formation limited to the area of the defect margin at both healing periods. The amounts of new bone and defect closure were similar among all groups. In the control and collagen sponge group, the center of the defect was depressed by surrounding tissues. In contrast, in BCP and BCPC group, the center of the defect did not depressed and the grafted materials maintained the space. And the augmented area was significantly higher in BCP and BCPC group compared to the control and collagen sponge group at both healing periods (p < 0.05). Conclusions: The BCPC and BCP demonstrated proper space maintaining capacity and osteoconductive property, suggesting BCPC can be efficiently utilized in various clinical situations.

Original languageEnglish
Article number1
JournalBiomaterials Research
Volume19
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Calcium phosphate
Collagen
Rabbits
Defects
Composite materials
Porifera
Bone
hydroxyapatite-beta tricalcium phosphate
Osteogenesis
Animals
Tissue
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

Cite this

@article{e253322a8f5c45c3872ffdf79fb7b272,
title = "Comparative evaluation of biphasic calcium phosphate and biphasic calcium phosphate collagen composite on osteoconductive potency in rabbit calvarial defect",
abstract = "Background: The aim of this study was to determine the osteoconductivity of biphasic calcium phosphate collagen composite (BCPC) in rabbit calvarial defect model by comparing with biphasic calcium phosphate (BCP). Four 8 mm diameter bicortical calvarial defects were made in ten rabbits. Each of the defects was randomly assigned and filled with 1) collagen sponge, 2) BCP, 3) BCPC, and 4) nothing as control. The animals were sacrificed at either 2 weeks (n = 5) or 8 weeks (n = 5) healing period. Results: All groups showed wedge shaped new bone formation limited to the area of the defect margin at both healing periods. The amounts of new bone and defect closure were similar among all groups. In the control and collagen sponge group, the center of the defect was depressed by surrounding tissues. In contrast, in BCP and BCPC group, the center of the defect did not depressed and the grafted materials maintained the space. And the augmented area was significantly higher in BCP and BCPC group compared to the control and collagen sponge group at both healing periods (p < 0.05). Conclusions: The BCPC and BCP demonstrated proper space maintaining capacity and osteoconductive property, suggesting BCPC can be efficiently utilized in various clinical situations.",
author = "Lee, {Eun Ung} and Kim, {Dong Ju} and Lim, {Hyun Chang} and Lee, {Jung Seok} and Jung, {Ui Won} and Choi, {Seong Ho}",
year = "2015",
month = "1",
day = "1",
doi = "10.1186/s40824-014-0026-7",
language = "English",
volume = "19",
journal = "Biomaterials Research",
issn = "2055-7124",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

Comparative evaluation of biphasic calcium phosphate and biphasic calcium phosphate collagen composite on osteoconductive potency in rabbit calvarial defect. / Lee, Eun Ung; Kim, Dong Ju; Lim, Hyun Chang; Lee, Jung Seok; Jung, Ui Won; Choi, Seong Ho.

In: Biomaterials Research, Vol. 19, No. 1, 1, 01.01.2015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparative evaluation of biphasic calcium phosphate and biphasic calcium phosphate collagen composite on osteoconductive potency in rabbit calvarial defect

AU - Lee, Eun Ung

AU - Kim, Dong Ju

AU - Lim, Hyun Chang

AU - Lee, Jung Seok

AU - Jung, Ui Won

AU - Choi, Seong Ho

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: The aim of this study was to determine the osteoconductivity of biphasic calcium phosphate collagen composite (BCPC) in rabbit calvarial defect model by comparing with biphasic calcium phosphate (BCP). Four 8 mm diameter bicortical calvarial defects were made in ten rabbits. Each of the defects was randomly assigned and filled with 1) collagen sponge, 2) BCP, 3) BCPC, and 4) nothing as control. The animals were sacrificed at either 2 weeks (n = 5) or 8 weeks (n = 5) healing period. Results: All groups showed wedge shaped new bone formation limited to the area of the defect margin at both healing periods. The amounts of new bone and defect closure were similar among all groups. In the control and collagen sponge group, the center of the defect was depressed by surrounding tissues. In contrast, in BCP and BCPC group, the center of the defect did not depressed and the grafted materials maintained the space. And the augmented area was significantly higher in BCP and BCPC group compared to the control and collagen sponge group at both healing periods (p < 0.05). Conclusions: The BCPC and BCP demonstrated proper space maintaining capacity and osteoconductive property, suggesting BCPC can be efficiently utilized in various clinical situations.

AB - Background: The aim of this study was to determine the osteoconductivity of biphasic calcium phosphate collagen composite (BCPC) in rabbit calvarial defect model by comparing with biphasic calcium phosphate (BCP). Four 8 mm diameter bicortical calvarial defects were made in ten rabbits. Each of the defects was randomly assigned and filled with 1) collagen sponge, 2) BCP, 3) BCPC, and 4) nothing as control. The animals were sacrificed at either 2 weeks (n = 5) or 8 weeks (n = 5) healing period. Results: All groups showed wedge shaped new bone formation limited to the area of the defect margin at both healing periods. The amounts of new bone and defect closure were similar among all groups. In the control and collagen sponge group, the center of the defect was depressed by surrounding tissues. In contrast, in BCP and BCPC group, the center of the defect did not depressed and the grafted materials maintained the space. And the augmented area was significantly higher in BCP and BCPC group compared to the control and collagen sponge group at both healing periods (p < 0.05). Conclusions: The BCPC and BCP demonstrated proper space maintaining capacity and osteoconductive property, suggesting BCPC can be efficiently utilized in various clinical situations.

UR - http://www.scopus.com/inward/record.url?scp=85008264250&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85008264250&partnerID=8YFLogxK

U2 - 10.1186/s40824-014-0026-7

DO - 10.1186/s40824-014-0026-7

M3 - Article

AN - SCOPUS:85008264250

VL - 19

JO - Biomaterials Research

JF - Biomaterials Research

SN - 2055-7124

IS - 1

M1 - 1

ER -