Comparative study of histological features between core needle biopsy and surgical excision in phyllodes tumor

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We analyzed histopathological features of core needle biopsy (CNB) and surgical excision specimen comparatively in 129 patients with surgically proven phyllodes tumor (PT). Stromal characteristics including cellularity, atypia, mitosis, overgrowth, tissue fragmentation, and the tumor margin were assessed. Benign/borderline/malignant phyllodes tumor (PT) were diagnosed in 90 (69.8%)/30 (23.3%)/9 (7.0%) patients. Among the 90 cases of benign PTs, 67 cases (74.4%) were diagnosed concordantly in CNB. For borderline and malignant PTs, three out of eight (26.6%) and four out of nine (44.4%) cases were diagnosed concordantly in CNBs. All 50 cases of discordant diagnosis were underestimated in matched CNBs, especially in their stromal cellularity and mitosis. The size of tumor is larger in discordant cases of PT (P= 0.013). The concordant rate of diagnosis between CNB and surgical excision was about 60% and accordingly, grading of PT based on the histological findings in CNBs has limitation. The discordance comes from heterogeneous stromal properties of PTs.

Original languageEnglish
Pages (from-to)120-126
Number of pages7
JournalPathology International
Volume62
Issue number2
DOIs
Publication statusPublished - 2012 Feb 1

Fingerprint

Phyllodes Tumor
Large-Core Needle Biopsy
Mitosis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

@article{e0c12a3bcdca4872b4ee64466a271827,
title = "Comparative study of histological features between core needle biopsy and surgical excision in phyllodes tumor",
abstract = "We analyzed histopathological features of core needle biopsy (CNB) and surgical excision specimen comparatively in 129 patients with surgically proven phyllodes tumor (PT). Stromal characteristics including cellularity, atypia, mitosis, overgrowth, tissue fragmentation, and the tumor margin were assessed. Benign/borderline/malignant phyllodes tumor (PT) were diagnosed in 90 (69.8{\%})/30 (23.3{\%})/9 (7.0{\%}) patients. Among the 90 cases of benign PTs, 67 cases (74.4{\%}) were diagnosed concordantly in CNB. For borderline and malignant PTs, three out of eight (26.6{\%}) and four out of nine (44.4{\%}) cases were diagnosed concordantly in CNBs. All 50 cases of discordant diagnosis were underestimated in matched CNBs, especially in their stromal cellularity and mitosis. The size of tumor is larger in discordant cases of PT (P= 0.013). The concordant rate of diagnosis between CNB and surgical excision was about 60{\%} and accordingly, grading of PT based on the histological findings in CNBs has limitation. The discordance comes from heterogeneous stromal properties of PTs.",
author = "Junjeong Choi and Koo, {Ja Seung}",
year = "2012",
month = "2",
day = "1",
doi = "10.1111/j.1440-1827.2011.02761.x",
language = "English",
volume = "62",
pages = "120--126",
journal = "Pathology International",
issn = "1320-5463",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Comparative study of histological features between core needle biopsy and surgical excision in phyllodes tumor

AU - Choi, Junjeong

AU - Koo, Ja Seung

PY - 2012/2/1

Y1 - 2012/2/1

N2 - We analyzed histopathological features of core needle biopsy (CNB) and surgical excision specimen comparatively in 129 patients with surgically proven phyllodes tumor (PT). Stromal characteristics including cellularity, atypia, mitosis, overgrowth, tissue fragmentation, and the tumor margin were assessed. Benign/borderline/malignant phyllodes tumor (PT) were diagnosed in 90 (69.8%)/30 (23.3%)/9 (7.0%) patients. Among the 90 cases of benign PTs, 67 cases (74.4%) were diagnosed concordantly in CNB. For borderline and malignant PTs, three out of eight (26.6%) and four out of nine (44.4%) cases were diagnosed concordantly in CNBs. All 50 cases of discordant diagnosis were underestimated in matched CNBs, especially in their stromal cellularity and mitosis. The size of tumor is larger in discordant cases of PT (P= 0.013). The concordant rate of diagnosis between CNB and surgical excision was about 60% and accordingly, grading of PT based on the histological findings in CNBs has limitation. The discordance comes from heterogeneous stromal properties of PTs.

AB - We analyzed histopathological features of core needle biopsy (CNB) and surgical excision specimen comparatively in 129 patients with surgically proven phyllodes tumor (PT). Stromal characteristics including cellularity, atypia, mitosis, overgrowth, tissue fragmentation, and the tumor margin were assessed. Benign/borderline/malignant phyllodes tumor (PT) were diagnosed in 90 (69.8%)/30 (23.3%)/9 (7.0%) patients. Among the 90 cases of benign PTs, 67 cases (74.4%) were diagnosed concordantly in CNB. For borderline and malignant PTs, three out of eight (26.6%) and four out of nine (44.4%) cases were diagnosed concordantly in CNBs. All 50 cases of discordant diagnosis were underestimated in matched CNBs, especially in their stromal cellularity and mitosis. The size of tumor is larger in discordant cases of PT (P= 0.013). The concordant rate of diagnosis between CNB and surgical excision was about 60% and accordingly, grading of PT based on the histological findings in CNBs has limitation. The discordance comes from heterogeneous stromal properties of PTs.

UR - http://www.scopus.com/inward/record.url?scp=84855911104&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855911104&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1827.2011.02761.x

DO - 10.1111/j.1440-1827.2011.02761.x

M3 - Article

C2 - 22243782

AN - SCOPUS:84855911104

VL - 62

SP - 120

EP - 126

JO - Pathology International

JF - Pathology International

SN - 1320-5463

IS - 2

ER -