Comparative study of telmisartan tablets prepared via the wet granulation method and Pritor™ prepared using the spray-drying method

Junsung Park, Hee Jun Park, Wonkyung Cho, Kwang Ho Cha, Wonki Yeon, Min Soo Kim, Jeong Soo Kim, Sung Joo Hwang

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9 Citations (Scopus)

Abstract

The wet granulation method was successfully used to manufacture amorphous telmisartan tablets (CNU) for comparison with the spray-drying method, used for Pritor™. Drug crystallinity in the tablet was characterized using differential scanning calorimetry and powder Xray diffraction, and pharmaceutical properties of the tablets such as hardness, friability, water absorption, and in vitro dissolution in pH 1.2, 4.0, 6.8 and 7.5 were characterized. Especially with regard to the water absorption feature, the CNU tablets showed better performance by maintaining their original structures and by absorbing less water. Since both PritorTM and CNU tablets had similar physical properties of crystallinity, hardness, friability, and > 50 f 2 value in an in vitro dissolution study, the bioequivalence of CNU tablets should be analyzed in a future in vivo study. Therefore, telmisartan tablets can be produced using a more economical and easier method than that used to produce Pritor™ tablets.

Original languageEnglish
Pages (from-to)463-468
Number of pages6
JournalArchives of pharmacal research
Volume34
Issue number3
DOIs
Publication statusPublished - 2011 Mar 1

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All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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