Comparison between a manual squamous cell carcinoma antigen assay and an automated assay in a clinical setting

Saejin Lee, Juwon Kim, Young Uh, Hyon Suk Kim, Jong Han Lee

Research output: Contribution to journalArticle

Abstract

Objective: To compare a manual squamous cell carcinoma antigen (SCCA) assay and an automated SCCA assay in a clinical setting. Methods: We included, in this study, a total of 158 specimens that had been tested using the manual SCCA assay. The CanAg SCC EIA assay and the Elecsys SCC were compared for their clinical settings. Results: Within-run and between-day coefficients of variation (CVs, %) were lower than 3%. Comparison of the manual and automated SCCA assays yielded good correlation. The correlation coefficient (R2) between the CanAg SCC EIA and Elecsys SCC assay results was 0.989 (P <.001) and the overall concordance rate was 94.3%. Conclusions: We report that the Elecsys SCC automated SCCA assay yielded performance comparable to that of the manual SCCA assay: the automated assay reduced the number of manual steps and test turnaround time.

Original languageEnglish
Pages (from-to)254-258
Number of pages5
JournalLab Medicine
Volume49
Issue number3
DOIs
Publication statusPublished - 2018 Aug 1

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

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