Comparison between sirolimus- and paclitaxel-eluting stents for the treatment of chronic total occlusions

Jae Sik Jang, Myeong Ki Hong, Cheol Whan Lee, Duk Woo Park, Bong Ki Lee, Young Hak Kim, Ki Hoon Han, Jae Joong Kim, Seong Wook Park, Seung Jung Park

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30 Citations (Scopus)

Abstract

OBJECTIVES: This study evaluated the clinical and angiographic effectiveness of sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) implantation for chronic total occlusion (CTO) lesions. BACKGROUND: It has not been known which drug-eluting stent, SES vs. PES, is superior for the treatment of CTO lesions. METHODS: This study comprises 107 CTO lesions which were successfully treated with SES implantation and 29 CTO lesions with PES implantation. Six-month angiographic restenosis rates and major adverse cardiac events (MACE) including death, nonfatal myocardial infarction and target lesion revascularization were compared between the two groups. RESULTS: Baseline clinical characteristics were similar between the two groups. The procedural success rate was 98.1% in the SES group and 100% in the PES group. There was 1 sudden death due to in-hospital acute thrombosis in the PES group. There were no significant differences in baseline angiographic measures between both groups, except larger postprocedural minimal luminal diameter and acute gain in the PES group. At 6-month angiographic follow up, the restenosis rate was significantly higher in the PES group (28.6% vs. 9.4%; p = 0.020). Similarly, the late loss was significantly higher in the PES group (0.8 ± 0.8 mm vs. 0.4 ± 0.8 mm; p = 0.025). At one-year follow up, the MACE-free survival rate was significantly higher in the SES group (95.8% vs. 85.8%; p = 0.049). CONCLUSIONS: The implantation of SES in the treatment of CTO lesions showed more favorable results regarding restenosis and clinical outcomes compared with PES implantation.

Original languageEnglish
Pages (from-to)205-208
Number of pages4
JournalJournal of Invasive Cardiology
Volume18
Issue number5
Publication statusPublished - 2006 May

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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