Abstract
Background: The purpose of this study was to compare the efficacy of rotational atherectomy (RA) with simple balloon angioplasty, prior to beta-radiation therapy with a rhenium-188-mercaptoacetyltriglycine ( 188 Re-MAG 3 )-filled balloon for diffuse in-stent restenosis (ISR). Methods: After completing 50 cases with RA prior to beta-radiation (Group I), we performed optimal balloon angioplasty followed by beta-radiation in the next 53 consecutive patients (Group II) for the treatment of diffuse ISR. The radiation dose was 15 Gy at a depth of 1.0 mm into the vessel wall. Results: The baseline clinical and angiographic characteristics were similar between the two groups. The mean length of the lesion was 25.6±12.7 mm in Group I and 22.9±8.6 mm in Group II (p=0.26). Radiation was successfully delivered to all patients, with a mean irradiation time of 179±55 s. The 6-month angiographic restenosis rate was 10% (5/50) in Group I versus 33% (17/51) in Group II (p=0.007). No adverse event including myocardial infarction, death, or stent thrombosis occurred during the 1-year follow-up period. The risk of a target lesion revascularization or a major adverse cardiac event was significantly lower in Group I than in Group II (two patients in Group I vs. nine patients in Group II; OR, 0.20; 95% CI, 0.04-0.96; p=0.04). Conclusion: Concomitant treatment with rotational atherectomy and beta-irradiation using a 188 Re-MAG 3 -filled balloon for diffuse ISR has a synergistic effect, in terms of 6-month angiographic restenosis and 1-year cardiac event-free survival.
| Original language | English |
|---|---|
| Pages (from-to) | 179-185 |
| Number of pages | 7 |
| Journal | International Journal of Cardiology |
| Volume | 102 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2005 Jul 10 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cite this
}
Comparison of angiographic and clinical outcomes between rotational atherectomy versus balloon angioplasty followed by radiation therapy with a rhenium-188-mercaptoacetyltriglycine-filled balloon in the treatment of diffuse in-stent restenosis. / Lee, Seung Whan; Park, Seong Wook; Hong, Myeongki; Lee, Jae Hwan; Kim, Young Hak; Dae, Hyuk Moon; Seung, Jun Oh; Cheol, Whan Lee; Kim, Jae Joong; Park, Seung Jung.
In: International Journal of Cardiology, Vol. 102, No. 2, 10.07.2005, p. 179-185.Research output: Contribution to journal › Article
TY - JOUR
T1 - Comparison of angiographic and clinical outcomes between rotational atherectomy versus balloon angioplasty followed by radiation therapy with a rhenium-188-mercaptoacetyltriglycine-filled balloon in the treatment of diffuse in-stent restenosis
AU - Lee, Seung Whan
AU - Park, Seong Wook
AU - Hong, Myeongki
AU - Lee, Jae Hwan
AU - Kim, Young Hak
AU - Dae, Hyuk Moon
AU - Seung, Jun Oh
AU - Cheol, Whan Lee
AU - Kim, Jae Joong
AU - Park, Seung Jung
PY - 2005/7/10
Y1 - 2005/7/10
N2 - Background: The purpose of this study was to compare the efficacy of rotational atherectomy (RA) with simple balloon angioplasty, prior to beta-radiation therapy with a rhenium-188-mercaptoacetyltriglycine ( 188 Re-MAG 3 )-filled balloon for diffuse in-stent restenosis (ISR). Methods: After completing 50 cases with RA prior to beta-radiation (Group I), we performed optimal balloon angioplasty followed by beta-radiation in the next 53 consecutive patients (Group II) for the treatment of diffuse ISR. The radiation dose was 15 Gy at a depth of 1.0 mm into the vessel wall. Results: The baseline clinical and angiographic characteristics were similar between the two groups. The mean length of the lesion was 25.6±12.7 mm in Group I and 22.9±8.6 mm in Group II (p=0.26). Radiation was successfully delivered to all patients, with a mean irradiation time of 179±55 s. The 6-month angiographic restenosis rate was 10% (5/50) in Group I versus 33% (17/51) in Group II (p=0.007). No adverse event including myocardial infarction, death, or stent thrombosis occurred during the 1-year follow-up period. The risk of a target lesion revascularization or a major adverse cardiac event was significantly lower in Group I than in Group II (two patients in Group I vs. nine patients in Group II; OR, 0.20; 95% CI, 0.04-0.96; p=0.04). Conclusion: Concomitant treatment with rotational atherectomy and beta-irradiation using a 188 Re-MAG 3 -filled balloon for diffuse ISR has a synergistic effect, in terms of 6-month angiographic restenosis and 1-year cardiac event-free survival.
AB - Background: The purpose of this study was to compare the efficacy of rotational atherectomy (RA) with simple balloon angioplasty, prior to beta-radiation therapy with a rhenium-188-mercaptoacetyltriglycine ( 188 Re-MAG 3 )-filled balloon for diffuse in-stent restenosis (ISR). Methods: After completing 50 cases with RA prior to beta-radiation (Group I), we performed optimal balloon angioplasty followed by beta-radiation in the next 53 consecutive patients (Group II) for the treatment of diffuse ISR. The radiation dose was 15 Gy at a depth of 1.0 mm into the vessel wall. Results: The baseline clinical and angiographic characteristics were similar between the two groups. The mean length of the lesion was 25.6±12.7 mm in Group I and 22.9±8.6 mm in Group II (p=0.26). Radiation was successfully delivered to all patients, with a mean irradiation time of 179±55 s. The 6-month angiographic restenosis rate was 10% (5/50) in Group I versus 33% (17/51) in Group II (p=0.007). No adverse event including myocardial infarction, death, or stent thrombosis occurred during the 1-year follow-up period. The risk of a target lesion revascularization or a major adverse cardiac event was significantly lower in Group I than in Group II (two patients in Group I vs. nine patients in Group II; OR, 0.20; 95% CI, 0.04-0.96; p=0.04). Conclusion: Concomitant treatment with rotational atherectomy and beta-irradiation using a 188 Re-MAG 3 -filled balloon for diffuse ISR has a synergistic effect, in terms of 6-month angiographic restenosis and 1-year cardiac event-free survival.
UR - http://www.scopus.com/inward/record.url?scp=20744451138&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20744451138&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2004.04.011
DO - 10.1016/j.ijcard.2004.04.011
M3 - Article
VL - 102
SP - 179
EP - 185
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 2
ER -