Abstract
Background: Angiographic pattern of in-stent restenosis (ISR) after drug-eluting stent (DES) implantation was known to be different to that after bare metal stent (BMS) implantation. But the different angiographic patterns of ISR and its prognosis between sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) has not been properly addressed in large scale studies. Objectives and methods: We evaluated the angiographic pattern of ISR and their subsequent clinical outcomes in 177 ISR lesions of 163 consecutive patients previously treated with SES (n = 97) or PES (n = 80) from February 2003 to April 2005. Results: In angiographic ISR pattern, diffuse ISR was more common in PES implantation (SES vs PES; 23.7% vs 48.7%, p = 0.001) mainly because of higher incidence of diffuse intrastent ISR (8.2% vs 33.8%, p < 0.001, respectively) whereas focal ISR was more common in SES implantation (76.3% vs 51.3%, p = 0.001, respectively) mainly because of higher incidence of focal margin ISR (27.8% vs 2.5%, p < 0.001, respectively). Among 177 ISR lesions, clinically driven target lesion revascularization (TLR) was performed in 53.6% in SES implantation and 56.3% in PES implantation (p = 0.725). Conclusion: Angiographic pattern of ISR differed after SES and PES implantation, but their subsequent TLR rate was similar to both types of DES.
| Original language | English |
|---|---|
| Pages (from-to) | 387-390 |
| Number of pages | 4 |
| Journal | International Journal of Cardiology |
| Volume | 120 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2007 Sep 3 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
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Comparison of angiographic patterns of in-stent restenosis between sirolimus- and paclitaxel-eluting stent. / Park, Chang Bum; Hong, Myeongki; Kim, Young Hak; Park, Duk Woo; Han, Ki Hoon; Lee, Cheol Whan; Kang, Duck Hyun; Song, Jae Kwan; Kim, Jae Joong; Park, Seong Wook; Park, Seung Jung.
In: International Journal of Cardiology, Vol. 120, No. 3, 03.09.2007, p. 387-390.Research output: Contribution to journal › Article
TY - JOUR
T1 - Comparison of angiographic patterns of in-stent restenosis between sirolimus- and paclitaxel-eluting stent
AU - Park, Chang Bum
AU - Hong, Myeongki
AU - Kim, Young Hak
AU - Park, Duk Woo
AU - Han, Ki Hoon
AU - Lee, Cheol Whan
AU - Kang, Duck Hyun
AU - Song, Jae Kwan
AU - Kim, Jae Joong
AU - Park, Seong Wook
AU - Park, Seung Jung
PY - 2007/9/3
Y1 - 2007/9/3
N2 - Background: Angiographic pattern of in-stent restenosis (ISR) after drug-eluting stent (DES) implantation was known to be different to that after bare metal stent (BMS) implantation. But the different angiographic patterns of ISR and its prognosis between sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) has not been properly addressed in large scale studies. Objectives and methods: We evaluated the angiographic pattern of ISR and their subsequent clinical outcomes in 177 ISR lesions of 163 consecutive patients previously treated with SES (n = 97) or PES (n = 80) from February 2003 to April 2005. Results: In angiographic ISR pattern, diffuse ISR was more common in PES implantation (SES vs PES; 23.7% vs 48.7%, p = 0.001) mainly because of higher incidence of diffuse intrastent ISR (8.2% vs 33.8%, p < 0.001, respectively) whereas focal ISR was more common in SES implantation (76.3% vs 51.3%, p = 0.001, respectively) mainly because of higher incidence of focal margin ISR (27.8% vs 2.5%, p < 0.001, respectively). Among 177 ISR lesions, clinically driven target lesion revascularization (TLR) was performed in 53.6% in SES implantation and 56.3% in PES implantation (p = 0.725). Conclusion: Angiographic pattern of ISR differed after SES and PES implantation, but their subsequent TLR rate was similar to both types of DES.
AB - Background: Angiographic pattern of in-stent restenosis (ISR) after drug-eluting stent (DES) implantation was known to be different to that after bare metal stent (BMS) implantation. But the different angiographic patterns of ISR and its prognosis between sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) has not been properly addressed in large scale studies. Objectives and methods: We evaluated the angiographic pattern of ISR and their subsequent clinical outcomes in 177 ISR lesions of 163 consecutive patients previously treated with SES (n = 97) or PES (n = 80) from February 2003 to April 2005. Results: In angiographic ISR pattern, diffuse ISR was more common in PES implantation (SES vs PES; 23.7% vs 48.7%, p = 0.001) mainly because of higher incidence of diffuse intrastent ISR (8.2% vs 33.8%, p < 0.001, respectively) whereas focal ISR was more common in SES implantation (76.3% vs 51.3%, p = 0.001, respectively) mainly because of higher incidence of focal margin ISR (27.8% vs 2.5%, p < 0.001, respectively). Among 177 ISR lesions, clinically driven target lesion revascularization (TLR) was performed in 53.6% in SES implantation and 56.3% in PES implantation (p = 0.725). Conclusion: Angiographic pattern of ISR differed after SES and PES implantation, but their subsequent TLR rate was similar to both types of DES.
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U2 - 10.1016/j.ijcard.2006.10.014
DO - 10.1016/j.ijcard.2006.10.014
M3 - Article
VL - 120
SP - 387
EP - 390
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 3
ER -