Comparison of angiographic patterns of in-stent restenosis between sirolimus- and paclitaxel-eluting stent

Chang Bum Park, Myeongki Hong, Young Hak Kim, Duk Woo Park, Ki Hoon Han, Cheol Whan Lee, Duck Hyun Kang, Jae Kwan Song, Jae Joong Kim, Seong Wook Park, Seung Jung Park

Research output: Contribution to journalArticle

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Abstract

Background: Angiographic pattern of in-stent restenosis (ISR) after drug-eluting stent (DES) implantation was known to be different to that after bare metal stent (BMS) implantation. But the different angiographic patterns of ISR and its prognosis between sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) has not been properly addressed in large scale studies. Objectives and methods: We evaluated the angiographic pattern of ISR and their subsequent clinical outcomes in 177 ISR lesions of 163 consecutive patients previously treated with SES (n = 97) or PES (n = 80) from February 2003 to April 2005. Results: In angiographic ISR pattern, diffuse ISR was more common in PES implantation (SES vs PES; 23.7% vs 48.7%, p = 0.001) mainly because of higher incidence of diffuse intrastent ISR (8.2% vs 33.8%, p < 0.001, respectively) whereas focal ISR was more common in SES implantation (76.3% vs 51.3%, p = 0.001, respectively) mainly because of higher incidence of focal margin ISR (27.8% vs 2.5%, p < 0.001, respectively). Among 177 ISR lesions, clinically driven target lesion revascularization (TLR) was performed in 53.6% in SES implantation and 56.3% in PES implantation (p = 0.725). Conclusion: Angiographic pattern of ISR differed after SES and PES implantation, but their subsequent TLR rate was similar to both types of DES.

Original languageEnglish
Pages (from-to)387-390
Number of pages4
JournalInternational Journal of Cardiology
Volume120
Issue number3
DOIs
Publication statusPublished - 2007 Sep 3

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Sirolimus
Paclitaxel
Stents
Drug-Eluting Stents

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Park, Chang Bum ; Hong, Myeongki ; Kim, Young Hak ; Park, Duk Woo ; Han, Ki Hoon ; Lee, Cheol Whan ; Kang, Duck Hyun ; Song, Jae Kwan ; Kim, Jae Joong ; Park, Seong Wook ; Park, Seung Jung. / Comparison of angiographic patterns of in-stent restenosis between sirolimus- and paclitaxel-eluting stent. In: International Journal of Cardiology. 2007 ; Vol. 120, No. 3. pp. 387-390.
@article{11d1c9f7a93d44f795a8630fb6fd7704,
title = "Comparison of angiographic patterns of in-stent restenosis between sirolimus- and paclitaxel-eluting stent",
abstract = "Background: Angiographic pattern of in-stent restenosis (ISR) after drug-eluting stent (DES) implantation was known to be different to that after bare metal stent (BMS) implantation. But the different angiographic patterns of ISR and its prognosis between sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) has not been properly addressed in large scale studies. Objectives and methods: We evaluated the angiographic pattern of ISR and their subsequent clinical outcomes in 177 ISR lesions of 163 consecutive patients previously treated with SES (n = 97) or PES (n = 80) from February 2003 to April 2005. Results: In angiographic ISR pattern, diffuse ISR was more common in PES implantation (SES vs PES; 23.7{\%} vs 48.7{\%}, p = 0.001) mainly because of higher incidence of diffuse intrastent ISR (8.2{\%} vs 33.8{\%}, p < 0.001, respectively) whereas focal ISR was more common in SES implantation (76.3{\%} vs 51.3{\%}, p = 0.001, respectively) mainly because of higher incidence of focal margin ISR (27.8{\%} vs 2.5{\%}, p < 0.001, respectively). Among 177 ISR lesions, clinically driven target lesion revascularization (TLR) was performed in 53.6{\%} in SES implantation and 56.3{\%} in PES implantation (p = 0.725). Conclusion: Angiographic pattern of ISR differed after SES and PES implantation, but their subsequent TLR rate was similar to both types of DES.",
author = "Park, {Chang Bum} and Myeongki Hong and Kim, {Young Hak} and Park, {Duk Woo} and Han, {Ki Hoon} and Lee, {Cheol Whan} and Kang, {Duck Hyun} and Song, {Jae Kwan} and Kim, {Jae Joong} and Park, {Seong Wook} and Park, {Seung Jung}",
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Park, CB, Hong, M, Kim, YH, Park, DW, Han, KH, Lee, CW, Kang, DH, Song, JK, Kim, JJ, Park, SW & Park, SJ 2007, 'Comparison of angiographic patterns of in-stent restenosis between sirolimus- and paclitaxel-eluting stent', International Journal of Cardiology, vol. 120, no. 3, pp. 387-390. https://doi.org/10.1016/j.ijcard.2006.10.014

Comparison of angiographic patterns of in-stent restenosis between sirolimus- and paclitaxel-eluting stent. / Park, Chang Bum; Hong, Myeongki; Kim, Young Hak; Park, Duk Woo; Han, Ki Hoon; Lee, Cheol Whan; Kang, Duck Hyun; Song, Jae Kwan; Kim, Jae Joong; Park, Seong Wook; Park, Seung Jung.

In: International Journal of Cardiology, Vol. 120, No. 3, 03.09.2007, p. 387-390.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of angiographic patterns of in-stent restenosis between sirolimus- and paclitaxel-eluting stent

AU - Park, Chang Bum

AU - Hong, Myeongki

AU - Kim, Young Hak

AU - Park, Duk Woo

AU - Han, Ki Hoon

AU - Lee, Cheol Whan

AU - Kang, Duck Hyun

AU - Song, Jae Kwan

AU - Kim, Jae Joong

AU - Park, Seong Wook

AU - Park, Seung Jung

PY - 2007/9/3

Y1 - 2007/9/3

N2 - Background: Angiographic pattern of in-stent restenosis (ISR) after drug-eluting stent (DES) implantation was known to be different to that after bare metal stent (BMS) implantation. But the different angiographic patterns of ISR and its prognosis between sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) has not been properly addressed in large scale studies. Objectives and methods: We evaluated the angiographic pattern of ISR and their subsequent clinical outcomes in 177 ISR lesions of 163 consecutive patients previously treated with SES (n = 97) or PES (n = 80) from February 2003 to April 2005. Results: In angiographic ISR pattern, diffuse ISR was more common in PES implantation (SES vs PES; 23.7% vs 48.7%, p = 0.001) mainly because of higher incidence of diffuse intrastent ISR (8.2% vs 33.8%, p < 0.001, respectively) whereas focal ISR was more common in SES implantation (76.3% vs 51.3%, p = 0.001, respectively) mainly because of higher incidence of focal margin ISR (27.8% vs 2.5%, p < 0.001, respectively). Among 177 ISR lesions, clinically driven target lesion revascularization (TLR) was performed in 53.6% in SES implantation and 56.3% in PES implantation (p = 0.725). Conclusion: Angiographic pattern of ISR differed after SES and PES implantation, but their subsequent TLR rate was similar to both types of DES.

AB - Background: Angiographic pattern of in-stent restenosis (ISR) after drug-eluting stent (DES) implantation was known to be different to that after bare metal stent (BMS) implantation. But the different angiographic patterns of ISR and its prognosis between sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) has not been properly addressed in large scale studies. Objectives and methods: We evaluated the angiographic pattern of ISR and their subsequent clinical outcomes in 177 ISR lesions of 163 consecutive patients previously treated with SES (n = 97) or PES (n = 80) from February 2003 to April 2005. Results: In angiographic ISR pattern, diffuse ISR was more common in PES implantation (SES vs PES; 23.7% vs 48.7%, p = 0.001) mainly because of higher incidence of diffuse intrastent ISR (8.2% vs 33.8%, p < 0.001, respectively) whereas focal ISR was more common in SES implantation (76.3% vs 51.3%, p = 0.001, respectively) mainly because of higher incidence of focal margin ISR (27.8% vs 2.5%, p < 0.001, respectively). Among 177 ISR lesions, clinically driven target lesion revascularization (TLR) was performed in 53.6% in SES implantation and 56.3% in PES implantation (p = 0.725). Conclusion: Angiographic pattern of ISR differed after SES and PES implantation, but their subsequent TLR rate was similar to both types of DES.

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