Comparison of bone mineral loss by combined androgen block agonist versus GnRH in patients with prostate cancer: A 12 month-prospective observational study

Sung Han Kim, Jae Young Joung, Sohee Kim, Koon Ho Rha, Hyeong Gon Kim, Cheol Kwak, Ji Youl Lee, Seong Soo Jeon, Sung Kyu Hong, Hyeon Jeong, Moon Ki Jo, Dalsan You, In Gab Jeong, Jun Hyuk Hong, Choung Soo Kim

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Abstract

The multi-centre, prospective, observational study was designed to examine the efficacy of continuous combined androgen block (CAB) vs. GnRH agonist monotherapy in terms of bone mineral density (BMD) change during 12 months post-androgen deprivation therapy (ADT) in Asian prostate cancer patients. Multiple regression analysis and estimated the 10-year probability of major fractures among the patients with Fracture Risk Assessment Tool were conducted to investigate the underlying factors affecting BMD. Paired t-test to evaluate the change of BMD from baseline to 12 month, and two sample t-test to examine the difference of BMD changes were used between two groups. BMD significantly decreased in both the CAB and GnRH groups, with no group wise differences. The proportion of osteopenia or osteoporosis was slightly increased after the 12-month post-ADT. Ten-year probability of hip fracture and major osteoporotic fracture was approximately 3% and 5%, respectively. In conclusion, a significant decrease of BMD by 12-month ADT was observed without any differences between the two groups, whereas ADT-related BMD loss did not induce detrimental effects on bone health in terms of increased bone fracture risk. This was the first prospective study on BMD changes as a predictor of fracture during ADT in an Asian population.

Original languageEnglish
Article number39562
JournalScientific reports
Volume7
DOIs
Publication statusPublished - 2017 Mar 6

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compound A 12
Gonadotropin-Releasing Hormone
Bone Density
Androgens
Observational Studies
Minerals
Prostatic Neoplasms
Prospective Studies
Bone and Bones
Therapeutics
Osteoporotic Fractures
Metabolic Bone Diseases
Bone Fractures
Hip Fractures
Osteoporosis
Regression Analysis
Health

All Science Journal Classification (ASJC) codes

  • General

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Kim, Sung Han ; Joung, Jae Young ; Kim, Sohee ; Rha, Koon Ho ; Kim, Hyeong Gon ; Kwak, Cheol ; Lee, Ji Youl ; Jeon, Seong Soo ; Hong, Sung Kyu ; Jeong, Hyeon ; Jo, Moon Ki ; You, Dalsan ; Jeong, In Gab ; Hong, Jun Hyuk ; Kim, Choung Soo. / Comparison of bone mineral loss by combined androgen block agonist versus GnRH in patients with prostate cancer : A 12 month-prospective observational study. In: Scientific reports. 2017 ; Vol. 7.
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abstract = "The multi-centre, prospective, observational study was designed to examine the efficacy of continuous combined androgen block (CAB) vs. GnRH agonist monotherapy in terms of bone mineral density (BMD) change during 12 months post-androgen deprivation therapy (ADT) in Asian prostate cancer patients. Multiple regression analysis and estimated the 10-year probability of major fractures among the patients with Fracture Risk Assessment Tool were conducted to investigate the underlying factors affecting BMD. Paired t-test to evaluate the change of BMD from baseline to 12 month, and two sample t-test to examine the difference of BMD changes were used between two groups. BMD significantly decreased in both the CAB and GnRH groups, with no group wise differences. The proportion of osteopenia or osteoporosis was slightly increased after the 12-month post-ADT. Ten-year probability of hip fracture and major osteoporotic fracture was approximately 3{\%} and 5{\%}, respectively. In conclusion, a significant decrease of BMD by 12-month ADT was observed without any differences between the two groups, whereas ADT-related BMD loss did not induce detrimental effects on bone health in terms of increased bone fracture risk. This was the first prospective study on BMD changes as a predictor of fracture during ADT in an Asian population.",
author = "Kim, {Sung Han} and Joung, {Jae Young} and Sohee Kim and Rha, {Koon Ho} and Kim, {Hyeong Gon} and Cheol Kwak and Lee, {Ji Youl} and Jeon, {Seong Soo} and Hong, {Sung Kyu} and Hyeon Jeong and Jo, {Moon Ki} and Dalsan You and Jeong, {In Gab} and Hong, {Jun Hyuk} and Kim, {Choung Soo}",
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Kim, SH, Joung, JY, Kim, S, Rha, KH, Kim, HG, Kwak, C, Lee, JY, Jeon, SS, Hong, SK, Jeong, H, Jo, MK, You, D, Jeong, IG, Hong, JH & Kim, CS 2017, 'Comparison of bone mineral loss by combined androgen block agonist versus GnRH in patients with prostate cancer: A 12 month-prospective observational study', Scientific reports, vol. 7, 39562. https://doi.org/10.1038/srep39562

Comparison of bone mineral loss by combined androgen block agonist versus GnRH in patients with prostate cancer : A 12 month-prospective observational study. / Kim, Sung Han; Joung, Jae Young; Kim, Sohee; Rha, Koon Ho; Kim, Hyeong Gon; Kwak, Cheol; Lee, Ji Youl; Jeon, Seong Soo; Hong, Sung Kyu; Jeong, Hyeon; Jo, Moon Ki; You, Dalsan; Jeong, In Gab; Hong, Jun Hyuk; Kim, Choung Soo.

In: Scientific reports, Vol. 7, 39562, 06.03.2017.

Research output: Contribution to journalArticle

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T1 - Comparison of bone mineral loss by combined androgen block agonist versus GnRH in patients with prostate cancer

T2 - A 12 month-prospective observational study

AU - Kim, Sung Han

AU - Joung, Jae Young

AU - Kim, Sohee

AU - Rha, Koon Ho

AU - Kim, Hyeong Gon

AU - Kwak, Cheol

AU - Lee, Ji Youl

AU - Jeon, Seong Soo

AU - Hong, Sung Kyu

AU - Jeong, Hyeon

AU - Jo, Moon Ki

AU - You, Dalsan

AU - Jeong, In Gab

AU - Hong, Jun Hyuk

AU - Kim, Choung Soo

PY - 2017/3/6

Y1 - 2017/3/6

N2 - The multi-centre, prospective, observational study was designed to examine the efficacy of continuous combined androgen block (CAB) vs. GnRH agonist monotherapy in terms of bone mineral density (BMD) change during 12 months post-androgen deprivation therapy (ADT) in Asian prostate cancer patients. Multiple regression analysis and estimated the 10-year probability of major fractures among the patients with Fracture Risk Assessment Tool were conducted to investigate the underlying factors affecting BMD. Paired t-test to evaluate the change of BMD from baseline to 12 month, and two sample t-test to examine the difference of BMD changes were used between two groups. BMD significantly decreased in both the CAB and GnRH groups, with no group wise differences. The proportion of osteopenia or osteoporosis was slightly increased after the 12-month post-ADT. Ten-year probability of hip fracture and major osteoporotic fracture was approximately 3% and 5%, respectively. In conclusion, a significant decrease of BMD by 12-month ADT was observed without any differences between the two groups, whereas ADT-related BMD loss did not induce detrimental effects on bone health in terms of increased bone fracture risk. This was the first prospective study on BMD changes as a predictor of fracture during ADT in an Asian population.

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