Comparison of breast tissue markers for tumor localization in breast cancer patients undergoing neoadjuvant chemotherapy

Ja Ho Koo, Eun Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Youngjean Park, Min Jung Kim

Research output: Contribution to journalArticle

Abstract

Purpose: The purpose of this study was to compare the visibility of breast tissue markers in cases of breast cancer on ultrasonography (US) after neoadjuvant chemotherapy (NAC) and to analyze whether the type of marker affected the choice of localization method after NAC. Methods: We included 153 tissue markers inserted within breast cancers that showed pathologically complete response (pCR) after NAC from January 2012 to April 2017. One of three types of markers (a surgical clip, Cormark, or UltraClip) was inserted. Medical records and imaging findings were retrospectively reviewed. We compared the visibility of the different types of tissue markers on US after NAC, and also compared the imaging modalities used in the preoperative localization. The chi-square test, Fisher exact test, and multiple logistic regression were used for analysis. Results: Of the 153 tissue markers, 56 were surgical clips, 61 Cormark, and 36 UltraClip. After NAC, residual lesions were not seen on US in 42 cases (27.5%). In multivariate analysis, the visibility of the surgical clips and Cormark markers was better than that of the UltraClip markers (odds ratio [OR], 5.467; 95% confidence interal [CI], 1.717 to 17.410; P=0.004 and OR, 3.045; 95% CI, 1.074 to 8.628; P=0.036, respectively). Among the 131 cases where localization targeting the marker was required, the proportion of US-guided localizations was significantly higher when a surgical clip was used than when an UltraClip marker was used (OR, 5.566; 95% CI, 1.610 to 19.246; P=0.007) in the multivariate analysis. Conclusion: The type of breast tissue marker affected its visibility on US in cases with pCR after NAC, which in turn affected the localization methodology.

Original languageEnglish
Pages (from-to)336-344
Number of pages9
JournalUltrasonography
Volume38
Issue number4
DOIs
Publication statusPublished - 2019 Oct

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Tumor Biomarkers
Breast
Ultrasonography
Breast Neoplasms
Surgical Instruments
Drug Therapy
Odds Ratio
Multivariate Analysis
Diagnostic Imaging
Chi-Square Distribution
Medical Records
Logistic Models

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Koo, Ja Ho ; Kim, Eun Kyung ; Moon, Hee Jung ; Yoon, Jung Hyun ; Park, Vivian Youngjean ; Kim, Min Jung. / Comparison of breast tissue markers for tumor localization in breast cancer patients undergoing neoadjuvant chemotherapy. In: Ultrasonography. 2019 ; Vol. 38, No. 4. pp. 336-344.
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abstract = "Purpose: The purpose of this study was to compare the visibility of breast tissue markers in cases of breast cancer on ultrasonography (US) after neoadjuvant chemotherapy (NAC) and to analyze whether the type of marker affected the choice of localization method after NAC. Methods: We included 153 tissue markers inserted within breast cancers that showed pathologically complete response (pCR) after NAC from January 2012 to April 2017. One of three types of markers (a surgical clip, Cormark, or UltraClip) was inserted. Medical records and imaging findings were retrospectively reviewed. We compared the visibility of the different types of tissue markers on US after NAC, and also compared the imaging modalities used in the preoperative localization. The chi-square test, Fisher exact test, and multiple logistic regression were used for analysis. Results: Of the 153 tissue markers, 56 were surgical clips, 61 Cormark, and 36 UltraClip. After NAC, residual lesions were not seen on US in 42 cases (27.5{\%}). In multivariate analysis, the visibility of the surgical clips and Cormark markers was better than that of the UltraClip markers (odds ratio [OR], 5.467; 95{\%} confidence interal [CI], 1.717 to 17.410; P=0.004 and OR, 3.045; 95{\%} CI, 1.074 to 8.628; P=0.036, respectively). Among the 131 cases where localization targeting the marker was required, the proportion of US-guided localizations was significantly higher when a surgical clip was used than when an UltraClip marker was used (OR, 5.566; 95{\%} CI, 1.610 to 19.246; P=0.007) in the multivariate analysis. Conclusion: The type of breast tissue marker affected its visibility on US in cases with pCR after NAC, which in turn affected the localization methodology.",
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Comparison of breast tissue markers for tumor localization in breast cancer patients undergoing neoadjuvant chemotherapy. / Koo, Ja Ho; Kim, Eun Kyung; Moon, Hee Jung; Yoon, Jung Hyun; Park, Vivian Youngjean; Kim, Min Jung.

In: Ultrasonography, Vol. 38, No. 4, 10.2019, p. 336-344.

Research output: Contribution to journalArticle

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