Comparison of Clinical Characteristics of Pneumocystis Carinii Pneumonia between HIV Infected and Non-infected Persons

JunYong Choi, Kkot Sil Lee, Yoon Soo Park, Cheong Ho Cho, Sang Hoon Han, Suk Hoon Choi, Bum Sik Chin, Yoon Seon Park, Kyung Hee Chang, Young Goo Song, June Myung Kim

Research output: Contribution to journalReview article

Abstract

Background: Pneumocystis carinii pneumonia (PCP) is one of the most common cause of infection in patients with HIV infection. Recently, the incidence of PCP have been increasing in immunocompromised hosts without HIV infection. We compared the clinical characteristics of PCP between HIV infected and non-infected persons. Patients and Methods: We retrospectively reviewed the charts of 25 patients diagnosed as PCP from 1996 to 2002. Age, sex, underlying conditions, use of immunosuppressants, clinical courses, laboratory findings, treatment and prognosis were compared between HIV infected and non-infected persons. Results: Twenty-five patients with PCP were identified. 16 were HIV infected, and 9 were HIV non-infected. The mean age of overall patients was 43.4±13.2 years. Underlying conditions in HIV non-infected persons were hematologic malignancy (7 cases), solid organ transplant (1 case), and autoimmune disease (1 case). Seven cases (77.8%) of HIV non-infected persons had a history of steroid use. Mean duration of symptoms was longer in HIV infected persons than in HIV non-infected persons, but it was not statistically significant. PaO2 was lower in HIV infected persons (61.2±16.9 mmHg vs. 65.4±15.4), but it was not statistically significant. Chest X ray showed typical ground glass opacity in 12 cases (75%) of HIV infected persons and in 4 cases (44.4%) of HIV non-infected persons. Twelve cases (75%) of HIV infected persons were treated with steroid, as were 6 cases. (66.7%) of HIV non-infected persons. Ventilator care was needed in 6 cases (37.5%) of HIV infected persons and in 2 cases (22.2%) of HIV non-infected persons. Mortality of HIV infected persons was 50%, and that of HIV non-infected persons was 11.1%. Conclusions: PCP showed some different clinical characteristics between HIV infected and non-infected persons. Prospective studies regarding the risk factors of PCP, prophylaxis, treatment and prognosis in HIV infected and non-infected persons are warranted.

Original languageEnglish
Pages (from-to)370-377
Number of pages8
JournalTuberculosis and Respiratory Diseases
Volume55
Issue number4
DOIs
Publication statusPublished - 2003 Jan 1

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Pneumocystis Pneumonia
HIV
HIV Infections
Steroids

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Choi, JunYong ; Lee, Kkot Sil ; Park, Yoon Soo ; Cho, Cheong Ho ; Han, Sang Hoon ; Choi, Suk Hoon ; Chin, Bum Sik ; Park, Yoon Seon ; Chang, Kyung Hee ; Song, Young Goo ; Kim, June Myung. / Comparison of Clinical Characteristics of Pneumocystis Carinii Pneumonia between HIV Infected and Non-infected Persons. In: Tuberculosis and Respiratory Diseases. 2003 ; Vol. 55, No. 4. pp. 370-377.
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title = "Comparison of Clinical Characteristics of Pneumocystis Carinii Pneumonia between HIV Infected and Non-infected Persons",
abstract = "Background: Pneumocystis carinii pneumonia (PCP) is one of the most common cause of infection in patients with HIV infection. Recently, the incidence of PCP have been increasing in immunocompromised hosts without HIV infection. We compared the clinical characteristics of PCP between HIV infected and non-infected persons. Patients and Methods: We retrospectively reviewed the charts of 25 patients diagnosed as PCP from 1996 to 2002. Age, sex, underlying conditions, use of immunosuppressants, clinical courses, laboratory findings, treatment and prognosis were compared between HIV infected and non-infected persons. Results: Twenty-five patients with PCP were identified. 16 were HIV infected, and 9 were HIV non-infected. The mean age of overall patients was 43.4±13.2 years. Underlying conditions in HIV non-infected persons were hematologic malignancy (7 cases), solid organ transplant (1 case), and autoimmune disease (1 case). Seven cases (77.8{\%}) of HIV non-infected persons had a history of steroid use. Mean duration of symptoms was longer in HIV infected persons than in HIV non-infected persons, but it was not statistically significant. PaO2 was lower in HIV infected persons (61.2±16.9 mmHg vs. 65.4±15.4), but it was not statistically significant. Chest X ray showed typical ground glass opacity in 12 cases (75{\%}) of HIV infected persons and in 4 cases (44.4{\%}) of HIV non-infected persons. Twelve cases (75{\%}) of HIV infected persons were treated with steroid, as were 6 cases. (66.7{\%}) of HIV non-infected persons. Ventilator care was needed in 6 cases (37.5{\%}) of HIV infected persons and in 2 cases (22.2{\%}) of HIV non-infected persons. Mortality of HIV infected persons was 50{\%}, and that of HIV non-infected persons was 11.1{\%}. Conclusions: PCP showed some different clinical characteristics between HIV infected and non-infected persons. Prospective studies regarding the risk factors of PCP, prophylaxis, treatment and prognosis in HIV infected and non-infected persons are warranted.",
author = "JunYong Choi and Lee, {Kkot Sil} and Park, {Yoon Soo} and Cho, {Cheong Ho} and Han, {Sang Hoon} and Choi, {Suk Hoon} and Chin, {Bum Sik} and Park, {Yoon Seon} and Chang, {Kyung Hee} and Song, {Young Goo} and Kim, {June Myung}",
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language = "English",
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pages = "370--377",
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Choi, J, Lee, KS, Park, YS, Cho, CH, Han, SH, Choi, SH, Chin, BS, Park, YS, Chang, KH, Song, YG & Kim, JM 2003, 'Comparison of Clinical Characteristics of Pneumocystis Carinii Pneumonia between HIV Infected and Non-infected Persons', Tuberculosis and Respiratory Diseases, vol. 55, no. 4, pp. 370-377. https://doi.org/10.4046/trd.2003.55.4.370

Comparison of Clinical Characteristics of Pneumocystis Carinii Pneumonia between HIV Infected and Non-infected Persons. / Choi, JunYong; Lee, Kkot Sil; Park, Yoon Soo; Cho, Cheong Ho; Han, Sang Hoon; Choi, Suk Hoon; Chin, Bum Sik; Park, Yoon Seon; Chang, Kyung Hee; Song, Young Goo; Kim, June Myung.

In: Tuberculosis and Respiratory Diseases, Vol. 55, No. 4, 01.01.2003, p. 370-377.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Comparison of Clinical Characteristics of Pneumocystis Carinii Pneumonia between HIV Infected and Non-infected Persons

AU - Choi, JunYong

AU - Lee, Kkot Sil

AU - Park, Yoon Soo

AU - Cho, Cheong Ho

AU - Han, Sang Hoon

AU - Choi, Suk Hoon

AU - Chin, Bum Sik

AU - Park, Yoon Seon

AU - Chang, Kyung Hee

AU - Song, Young Goo

AU - Kim, June Myung

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Background: Pneumocystis carinii pneumonia (PCP) is one of the most common cause of infection in patients with HIV infection. Recently, the incidence of PCP have been increasing in immunocompromised hosts without HIV infection. We compared the clinical characteristics of PCP between HIV infected and non-infected persons. Patients and Methods: We retrospectively reviewed the charts of 25 patients diagnosed as PCP from 1996 to 2002. Age, sex, underlying conditions, use of immunosuppressants, clinical courses, laboratory findings, treatment and prognosis were compared between HIV infected and non-infected persons. Results: Twenty-five patients with PCP were identified. 16 were HIV infected, and 9 were HIV non-infected. The mean age of overall patients was 43.4±13.2 years. Underlying conditions in HIV non-infected persons were hematologic malignancy (7 cases), solid organ transplant (1 case), and autoimmune disease (1 case). Seven cases (77.8%) of HIV non-infected persons had a history of steroid use. Mean duration of symptoms was longer in HIV infected persons than in HIV non-infected persons, but it was not statistically significant. PaO2 was lower in HIV infected persons (61.2±16.9 mmHg vs. 65.4±15.4), but it was not statistically significant. Chest X ray showed typical ground glass opacity in 12 cases (75%) of HIV infected persons and in 4 cases (44.4%) of HIV non-infected persons. Twelve cases (75%) of HIV infected persons were treated with steroid, as were 6 cases. (66.7%) of HIV non-infected persons. Ventilator care was needed in 6 cases (37.5%) of HIV infected persons and in 2 cases (22.2%) of HIV non-infected persons. Mortality of HIV infected persons was 50%, and that of HIV non-infected persons was 11.1%. Conclusions: PCP showed some different clinical characteristics between HIV infected and non-infected persons. Prospective studies regarding the risk factors of PCP, prophylaxis, treatment and prognosis in HIV infected and non-infected persons are warranted.

AB - Background: Pneumocystis carinii pneumonia (PCP) is one of the most common cause of infection in patients with HIV infection. Recently, the incidence of PCP have been increasing in immunocompromised hosts without HIV infection. We compared the clinical characteristics of PCP between HIV infected and non-infected persons. Patients and Methods: We retrospectively reviewed the charts of 25 patients diagnosed as PCP from 1996 to 2002. Age, sex, underlying conditions, use of immunosuppressants, clinical courses, laboratory findings, treatment and prognosis were compared between HIV infected and non-infected persons. Results: Twenty-five patients with PCP were identified. 16 were HIV infected, and 9 were HIV non-infected. The mean age of overall patients was 43.4±13.2 years. Underlying conditions in HIV non-infected persons were hematologic malignancy (7 cases), solid organ transplant (1 case), and autoimmune disease (1 case). Seven cases (77.8%) of HIV non-infected persons had a history of steroid use. Mean duration of symptoms was longer in HIV infected persons than in HIV non-infected persons, but it was not statistically significant. PaO2 was lower in HIV infected persons (61.2±16.9 mmHg vs. 65.4±15.4), but it was not statistically significant. Chest X ray showed typical ground glass opacity in 12 cases (75%) of HIV infected persons and in 4 cases (44.4%) of HIV non-infected persons. Twelve cases (75%) of HIV infected persons were treated with steroid, as were 6 cases. (66.7%) of HIV non-infected persons. Ventilator care was needed in 6 cases (37.5%) of HIV infected persons and in 2 cases (22.2%) of HIV non-infected persons. Mortality of HIV infected persons was 50%, and that of HIV non-infected persons was 11.1%. Conclusions: PCP showed some different clinical characteristics between HIV infected and non-infected persons. Prospective studies regarding the risk factors of PCP, prophylaxis, treatment and prognosis in HIV infected and non-infected persons are warranted.

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U2 - 10.4046/trd.2003.55.4.370

DO - 10.4046/trd.2003.55.4.370

M3 - Review article

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VL - 55

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EP - 377

JO - Tuberculosis and Respiratory Diseases

JF - Tuberculosis and Respiratory Diseases

SN - 1738-3536

IS - 4

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