Background: Mutation in the gene encoding filaggrin (FLG) is a major predisposing factor for atopic dermatitis (AD), in association with distinct features such as increased allergic sensitization, higher severity, and frequent skin infections. Genetic diversity in FLG mutations exists across ethnicities. Objective: This study aimed to investigate the clinical features of AD according to the presence of FLG mutation in Korean individuals. Methods: We performed reverse blot hybridization assay to detect FLG mutation in Korean patients with AD. Classifying subjects into AD with or without FLG mutation, clinical features of AD and patch test results were compared between the two groups. Results: Among a total of 281 subjects, 39 (13.9%) were found to have FLG mutation. AD with FLG mutation was associated with higher risk of impetigo and eczema herpeticum but lower risk of prurigo nodularis. In the patch test, there was no difference in positive reactions of major contact allergens between the groups. Conclusion: In Korean patients with AD, FLG mutation was associated with more frequent skin infections but not with personal or family history of atopic diseases, allergic sensitization, contact allergy, and protracted course. It is important to consider other skin-bamer-related genes, such as KLK7 and SPINK5, and immune response-related genes in conjunction. (Korean J Dermatol 2019;57(7):363~370).
|Number of pages||8|
|Journal||Korean Journal of Dermatology|
|Publication status||Published - 2019 Aug|
Bibliographical notePublisher Copyright:
© 2019 Korean Dermatological Association. All rights reserved.
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