Comparison of Doppler ultrasonography and hepatic venous pressure gradient in assessing portal hypertension in liver cirrhosis

Phil Ho Jeong, Soonkoo Baik, Yeun Jong Choi, Dong Hoon Park, Moonyoung Kim, Hyunsoo Kim, DongKi Lee, Sang Ok Kwon, Young Ju Kim, Joong Wha Park, Nam Dong Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

BACKGROUND/AIMS: This prospective study aimed to determine if Doppler ultrasonography can be representative of hepatic venous pressure gradient (HVPG) in assessing the severity of portal hypertension and response to drug reducing portal pressure. METHODS: The HVPG and the parameters of Doppler ultrasonography including portal venous velocity (PVV) and splenic venous velocity, the pulsatility and resistive index of hepatic, splenic and renal arteries were measured in 105 patients with liver cirrhosis. In 31 patients the changes of hepatic venous pressure gradient and portal venous velocity after administration of terlipressin were evaluated. The patients who showed a reduction in HVPG of more than 20% of the baseline were defined as responders to terlipressin. RESULTS: Any Doppler ultrasonographic parameters did not correlate with HVPG. Both HVPG and PVV showed a highly significant reduction after the administration of terlipressin(-28.3 +/- 3.9%, -31.2 +/- 2.2% respectively). However, PVV decreased significantly not only in responders(31.7 +/- 2.4%) but also in nonresponders(29.5 +/- 6.1%). CONCLUSION: Doppler ultrasonography can not be representative of HVPG in assessing the severity of portal hypertension and response to drug reducing portal pressure in liver cirrhosis.

Original languageEnglish
Pages (from-to)264-270
Number of pages7
JournalTaehan Kan Hakhoe chi = The Korean journal of hepatology
Volume8
Issue number3
Publication statusPublished - 2002 Jan 1

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Doppler Ultrasonography
Venous Pressure
Portal Hypertension
Liver Cirrhosis
Liver
Portal Pressure
Splenic Artery
Hepatic Artery
Renal Artery
Pharmaceutical Preparations
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{15a94c9760e94336a3ba859973d2d170,
title = "Comparison of Doppler ultrasonography and hepatic venous pressure gradient in assessing portal hypertension in liver cirrhosis",
abstract = "BACKGROUND/AIMS: This prospective study aimed to determine if Doppler ultrasonography can be representative of hepatic venous pressure gradient (HVPG) in assessing the severity of portal hypertension and response to drug reducing portal pressure. METHODS: The HVPG and the parameters of Doppler ultrasonography including portal venous velocity (PVV) and splenic venous velocity, the pulsatility and resistive index of hepatic, splenic and renal arteries were measured in 105 patients with liver cirrhosis. In 31 patients the changes of hepatic venous pressure gradient and portal venous velocity after administration of terlipressin were evaluated. The patients who showed a reduction in HVPG of more than 20{\%} of the baseline were defined as responders to terlipressin. RESULTS: Any Doppler ultrasonographic parameters did not correlate with HVPG. Both HVPG and PVV showed a highly significant reduction after the administration of terlipressin(-28.3 +/- 3.9{\%}, -31.2 +/- 2.2{\%} respectively). However, PVV decreased significantly not only in responders(31.7 +/- 2.4{\%}) but also in nonresponders(29.5 +/- 6.1{\%}). CONCLUSION: Doppler ultrasonography can not be representative of HVPG in assessing the severity of portal hypertension and response to drug reducing portal pressure in liver cirrhosis.",
author = "Jeong, {Phil Ho} and Soonkoo Baik and Choi, {Yeun Jong} and Park, {Dong Hoon} and Moonyoung Kim and Hyunsoo Kim and DongKi Lee and Kwon, {Sang Ok} and Kim, {Young Ju} and Park, {Joong Wha} and Kim, {Nam Dong}",
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Comparison of Doppler ultrasonography and hepatic venous pressure gradient in assessing portal hypertension in liver cirrhosis. / Jeong, Phil Ho; Baik, Soonkoo; Choi, Yeun Jong; Park, Dong Hoon; Kim, Moonyoung; Kim, Hyunsoo; Lee, DongKi; Kwon, Sang Ok; Kim, Young Ju; Park, Joong Wha; Kim, Nam Dong.

In: Taehan Kan Hakhoe chi = The Korean journal of hepatology, Vol. 8, No. 3, 01.01.2002, p. 264-270.

Research output: Contribution to journalArticle

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T1 - Comparison of Doppler ultrasonography and hepatic venous pressure gradient in assessing portal hypertension in liver cirrhosis

AU - Jeong, Phil Ho

AU - Baik, Soonkoo

AU - Choi, Yeun Jong

AU - Park, Dong Hoon

AU - Kim, Moonyoung

AU - Kim, Hyunsoo

AU - Lee, DongKi

AU - Kwon, Sang Ok

AU - Kim, Young Ju

AU - Park, Joong Wha

AU - Kim, Nam Dong

PY - 2002/1/1

Y1 - 2002/1/1

N2 - BACKGROUND/AIMS: This prospective study aimed to determine if Doppler ultrasonography can be representative of hepatic venous pressure gradient (HVPG) in assessing the severity of portal hypertension and response to drug reducing portal pressure. METHODS: The HVPG and the parameters of Doppler ultrasonography including portal venous velocity (PVV) and splenic venous velocity, the pulsatility and resistive index of hepatic, splenic and renal arteries were measured in 105 patients with liver cirrhosis. In 31 patients the changes of hepatic venous pressure gradient and portal venous velocity after administration of terlipressin were evaluated. The patients who showed a reduction in HVPG of more than 20% of the baseline were defined as responders to terlipressin. RESULTS: Any Doppler ultrasonographic parameters did not correlate with HVPG. Both HVPG and PVV showed a highly significant reduction after the administration of terlipressin(-28.3 +/- 3.9%, -31.2 +/- 2.2% respectively). However, PVV decreased significantly not only in responders(31.7 +/- 2.4%) but also in nonresponders(29.5 +/- 6.1%). CONCLUSION: Doppler ultrasonography can not be representative of HVPG in assessing the severity of portal hypertension and response to drug reducing portal pressure in liver cirrhosis.

AB - BACKGROUND/AIMS: This prospective study aimed to determine if Doppler ultrasonography can be representative of hepatic venous pressure gradient (HVPG) in assessing the severity of portal hypertension and response to drug reducing portal pressure. METHODS: The HVPG and the parameters of Doppler ultrasonography including portal venous velocity (PVV) and splenic venous velocity, the pulsatility and resistive index of hepatic, splenic and renal arteries were measured in 105 patients with liver cirrhosis. In 31 patients the changes of hepatic venous pressure gradient and portal venous velocity after administration of terlipressin were evaluated. The patients who showed a reduction in HVPG of more than 20% of the baseline were defined as responders to terlipressin. RESULTS: Any Doppler ultrasonographic parameters did not correlate with HVPG. Both HVPG and PVV showed a highly significant reduction after the administration of terlipressin(-28.3 +/- 3.9%, -31.2 +/- 2.2% respectively). However, PVV decreased significantly not only in responders(31.7 +/- 2.4%) but also in nonresponders(29.5 +/- 6.1%). CONCLUSION: Doppler ultrasonography can not be representative of HVPG in assessing the severity of portal hypertension and response to drug reducing portal pressure in liver cirrhosis.

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